Harada Takayuki

Affiliation and department：
Job title： Department Head
Homepage URL (2)： http://www.igakuken.or.jp/retina/ , http://www.igakuken.or.jp/english/project/detail/pro26/retina2.html

Research field (2)： Neuroscience - general , Ophthalmology

Research keywords (21)：遺伝子治療 , 視神経再生 , 軸索伸長 , シナプス再生 , 緑内障 , 神経栄養因子 , 神経炎症 , 酸化ストレス , グリア細胞 , 神経変性疾患 , 網膜変性疾患 , 神経保護 , 神経再生 , DOCK3 , 神経細胞死 , GLAST , 虚血 , グルタミン酸毒性 , 発生・分化 , 視細胞 , 眼科学

Research theme for competitive and other funds (18)：

2024 - 2027 Elucidation of the molecular pathogenesis of glaucoma by glial cells
2021 - 2024 視覚経路の再構築による失明からの回復を目指した治療法の開発
2021 - 2024 Mechanisms underlying retinal glia-mediated glaucoma
2021 - 2024 Investigation into neuronal repair and functional recovery in neurodegenerative diseases
2019 - 2024 Development of new glaucoma therapy using effective delivery of factors associated with neuroprotection and axon regeneration

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Papers (155)：

Yuebing Wang, Musukha Mala Brahma, Kazuya Takahashi, Alessandra Nolia Blanco Hernandez, Koki Ichikawa, Syuntaro Minami, Yoshio Goshima, Takayuki Harada, Toshio Ohshima. Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma. Neuromolecular medicine. 2024. 26. 1. 13-13
Kazuhiko Namekata, Takahiko Noro, Euido Nishijima, Akiko Sotozono, Xiaoli Guo, Chikako Harada, Youichi Shinozaki, Yoshinori Mitamura, Tadashi Nakano, Takayuki Harada. Drug combination of topical ripasudil and brimonidine enhances neuroprotection in a mouse model of optic nerve injury. Journal of pharmacological sciences. 2024. 154. 4. 326-333
Youichi Shinozaki, Kazuhiko Namekata, Xiaoli Guo, Takayuki Harada. Glial cells as a promising therapeutic target of glaucoma: beyond the IOP. Frontiers in Ophthalmology. 2024. 3
篠崎陽一, Leung Alex, 行方和彦, 柏木賢治, 繁冨英治, 原田高幸, 大沼信一, 小泉修一. 次世代の病態解明と治療を目指してアストロサイト機能異常は正常眼圧緑内障発症様の症状を誘導する. 日本緑内障学会抄録集. 2023. 34回. 85-85
Kazuhiko Namekata, Naoki Tsuji, Xiaoli Guo, Euido Nishijima, Sari Honda, Yuta Kitamura, Atsushi Yamasaki, Masamichi Kishida, Jun Takeyama, Hirokazu Ishikawa, et al. Neuroprotection and axon regeneration by novel low-molecular-weight compounds through the modification of DOCK3 conformation. Cell death discovery. 2023. 9. 1. 166-166

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MISC (109)：

HAMADA Kentaro, SHINOZAKI Yoichi, SHINOZAKI Yoichi, NAMEKATA Kazuhiko, OHNO Nobuhiko, OHNO Nobuhiko, SEGAWA Takahiko, HARADA Takayuki, KASHIWAGI Kenji, KOIZUMI Shuichi, et al. P2Y₁ receptor is a novel target for anti-glaucoma treatment. 日本薬理学会年会(Web). 2021. 94th
篠崎陽一, 篠崎陽一, 行方和彦, 柏木賢治, 大野伸彦, 大野伸彦, 繁冨英治, 繁冨英治, 原田高幸, 小泉修一, et al. Astrocytes trigger early remodeling of optic nerve head in NTG model mouse. 日本眼科学会雑誌. 2021. 125
濱田健太郎, 篠崎陽一, 篠崎陽一, 行方和彦, 大野伸彦, 大野伸彦, 原田高幸, 柏木賢治, 小泉修一, 小泉修一. P2Y1 receptor loss causes ocular hypertension and loss of retinal ganglion cells. 日本眼科学会雑誌. 2021. 125
HAMADA Kentaro, SHINOZAKI Youichi, SEGAWA Takahiro, NAMEKATA Kazuhiko, OHNO Nobuhiko, OHNO Nobuhiko, HARADA Takayuki, KASHIWAGI Kenji, KOIZUMI Schuichi. Loss of P2Y₁ receptor causes ocular hypertension and glaucoma-like phenotype in mice. 日本薬理学会年会(Web). 2020. 93rd
HAMADA Kentaro, SHINOZAKI Yoichi, SHINOZAKI Yoichi, NAMEKATA Kazuhiko, OHNO Nobuhiko, OHNO Nobuhiko, SEGAWA Takahiro, HARADA Takayuki, KASHIWAGI Kenji, KOIZUMI Schuichi, et al. Hypertensive glaucoma is induced by impairment of P2Y1 receptor function. 日本神経化学会大会抄録集(Web). 2020. 63rd

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Professional career (1)：

M.D. Ph.D.

Work history (6)：

2024/04 - 現在東京都医学総合研究所疾患制御研究分野分野長
2020/04 - 現在東京都医学総合研究所病院等連携支援センターセンター長
2011/04 - 現在東京都医学総合研究所視覚病態プロジェクトプロジェクトリーダー
2015/04 - 2020/03 Tokyo Metropolitan Institute of Medical Science Department of Sensory and Motor Systems Department Head
2004/01 - 2011/03 東京都神経科学総合研究所分子神経生物学研究部門部門長

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