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Rchr
J-GLOBAL ID：201101013523982746
Update date: Mar. 22, 2025 Harada Takayuki
Harada Takayuki
Clips
Tokyo Metropolitan Institute of Medical Science
About Tokyo Metropolitan Institute of Medical Science
Job title： Department Head
Homepage URL (2)： http://www.igakuken.or.jp/retina/ , http://www.igakuken.or.jp/english/project/detail/pro26/retina2.html
Research keywords (21)：
遺伝子治療
, 視神経再生
, 軸索伸長
, シナプス再生
, 緑内障
, 神経栄養因子
, 神経炎症
, 酸化ストレス
, グリア細胞
, 神経変性疾患
, 網膜変性疾患
, 神経保護
, 神経再生
, DOCK3
, 神経細胞死
, GLAST
, 虚血
, グルタミン酸毒性
, 発生・分化
, 視細胞
, 眼科学
Research theme for competitive and other funds (18)： - 2024 - 2027 Elucidation of the molecular pathogenesis of glaucoma by glial cells
- 2021 - 2024 視覚経路の再構築による失明からの回復を目指した治療法の開発
- 2021 - 2024 Mechanisms underlying retinal glia-mediated glaucoma
- 2021 - 2024 Investigation into neuronal repair and functional recovery in neurodegenerative diseases
- 2019 - 2024 Development of new glaucoma therapy using effective delivery of factors associated with neuroprotection and axon regeneration
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- Takahiko Noro, Xiaoli Guo, Kazuhiko Namekata, Youichi Shinozaki, Nanako Hashimoto, Keiko Moriya-Ito, Chikako Harada, Tadashi Nakano, Takayuki Harada. Valproic acid prevents NMDA-induced retinal degeneration in marmosets. Neuroscience letters. 2025. 138197-138197
- Akiko Sotozono, Kazuhiko Namekata, Xiaoli Guo, Youichi Shinozaki, Chikako Harada, Takahiko Noro, Tadashi Nakano, Takayuki Harada. Membrane-anchored intracellular insulin receptor or insulin-like growth factor-1 receptor elicits ligand-independent downstream signaling. Biochemistry and Biophysics Reports. 2024. 39. 101799-101799
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Erika Seki, Xiaoli Guo, Kazuhiko Namekata, Takashi Komori, Hiroyuki Hayashi, Nobutaka Arai, Takayuki Harada.
ASK1 activation in glial cells in post-mortem multiple sclerosis tissue. Neuropathology. 2024. 45. 1. 20-29 - Yuebing Wang, Musukha Mala Brahma, Kazuya Takahashi, Alessandra Nolia Blanco Hernandez, Koki Ichikawa, Syuntaro Minami, Yoshio Goshima, Takayuki Harada, Toshio Ohshima. Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma. Neuromolecular medicine. 2024. 26. 1. 13-13
- Kazuhiko Namekata, Takahiko Noro, Euido Nishijima, Akiko Sotozono, Xiaoli Guo, Chikako Harada, Youichi Shinozaki, Yoshinori Mitamura, Tadashi Nakano, Takayuki Harada. Drug combination of topical ripasudil and brimonidine enhances neuroprotection in a mouse model of optic nerve injury. Journal of pharmacological sciences. 2024. 154. 4. 326-333
- HAMADA Kentaro, SHINOZAKI Yoichi, SHINOZAKI Yoichi, NAMEKATA Kazuhiko, OHNO Nobuhiko, OHNO Nobuhiko, SEGAWA Takahiko, HARADA Takayuki, KASHIWAGI Kenji, KOIZUMI Shuichi, et al. P2Y1 receptor is a novel target for anti-glaucoma treatment. 日本薬理学会年会(Web). 2021. 94th
- 篠崎陽一, 篠崎陽一, 行方和彦, 柏木賢治, 大野伸彦, 大野伸彦, 繁冨英治, 繁冨英治, 原田高幸, 小泉修一, et al. Astrocytes trigger early remodeling of optic nerve head in NTG model mouse. 日本眼科学会雑誌. 2021. 125
- 濱田健太郎, 篠崎陽一, 篠崎陽一, 行方和彦, 大野伸彦, 大野伸彦, 原田高幸, 柏木賢治, 小泉修一, 小泉修一. P2Y1 receptor loss causes ocular hypertension and loss of retinal ganglion cells. 日本眼科学会雑誌. 2021. 125
- HAMADA Kentaro, SHINOZAKI Youichi, SEGAWA Takahiro, NAMEKATA Kazuhiko, OHNO Nobuhiko, OHNO Nobuhiko, HARADA Takayuki, KASHIWAGI Kenji, KOIZUMI Schuichi. Loss of P2Y1 receptor causes ocular hypertension and glaucoma-like phenotype in mice. 日本薬理学会年会(Web). 2020. 93rd
- HAMADA Kentaro, SHINOZAKI Yoichi, SHINOZAKI Yoichi, NAMEKATA Kazuhiko, OHNO Nobuhiko, OHNO Nobuhiko, SEGAWA Takahiro, HARADA Takayuki, KASHIWAGI Kenji, KOIZUMI Schuichi, et al. Hypertensive glaucoma is induced by impairment of P2Y1 receptor function. 日本神経化学会大会抄録集(Web). 2020. 63rd
- M.D. Ph.D.
- 2024/04 - 現在 東京都医学総合研究所 疾患制御研究分野 分野長
- 2020/04 - 現在 東京都医学総合研究所 病院等連携支援センター センター長
- 2011/04 - 現在 東京都医学総合研究所 視覚病態プロジェクト プロジェクトリーダー
- 2015/04 - 2020/03 Tokyo Metropolitan Institute of Medical Science Department of Sensory and Motor Systems Department Head
- 2004/01 - 2011/03 東京都神経科学総合研究所 分子神経生物学研究部門 部門長
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