Research theme for competitive and other funds (17):
2022 - 2026 加齢に伴うタンパク質の構造・機能変化とその病理学的役割の解明
2019 - 2024 生命金属動態を制御するシャペロン分子ネットワークの解明
2019 - 2024 Integrated Biometal Science: Research to Explore Dynamics of Metals in Cellular System
2020 - 2022 Detection of misfolded Cu/Zn-superoxide dismutase proteins with Caenorhabditis elegans
2018 - 2020 分子夾雑環境におけるタンパク質の金属イオン獲得メカニズム
2016 - 2020 Understanding a mechanism regulating intracellular dynamics of metal ions
2017 - 2019 異常構造型脳タンパク質の経口摂取による神経変性疾患発症の可能性
2015 - 2017 脳タンパク質老化の伝播性と感染性を検証する線虫モデルの確立
2015 - 2017 Identification of intracellular zinc chaperones
2013 - 2016 A mechanism regulating the copper acquisition by intracellular proteins
2012 - 2014 シーディングによる脳内環境の破綻伝播メカニズムの解明
2012 - 2014 In vitro reconstitution of intracellular copper transport system
2010 - 2011 Molecular recognition of proteins regulating transport of copper ions in cells
2008 - 2009 A molecular mechanism regulating pathological aggregation of SOD1 proteins
2006 - 2007 ApoE蛋白質が制御するアミロイド線維の形成と除去の分子メカニズム
2006 - 2007 神経変性疾患に見られるアミロイド繊維の構造伝播メカニズム
2001 - 2001 圧力効果を利用した蛋白質による電子移動反応機構の解明
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Papers (91):
Yuki Shino, Norifumi Muraki, Yui Kobatake, Hiroaki Kamishina, Ryuichi Kato, Yoshiaki Furukawa. Disulfide-mediated oligomerization of mutant Cu/Zn-superoxide dismutase associated with canine degenerative myelopathy. Protein science : a publication of the Protein Society. 2024. 33. 12. e5210
Hiroshi Amesaka, Mizuho Hara, Yuki Sakai, Atsuko Shintani, Kaori Sue, Tomoyuki Yamanaka, Shun-Ichi Tanaka, Yoshiaki Furukawa. Engineering a monobody specific to monomeric Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis. Protein science : a publication of the Protein Society. 2024. 33. 4. e4961
Yoshiaki Furukawa, Atsuko Shintani, Shuhei Narikiyo, Kaori Sue, Masato Akutsu, Norifumi Muraki. Characterization of a novel cysteine-less Cu/Zn-superoxide dismutase in Paenibacillus lautus missing a conserved disulfide bond. The Journal of biological chemistry. 2023. 299. 8. 105040-105040
Kei Hashimoto, Seiji Watanabe, Masato Akutsu, Norifumi Muraki, Hiroaki Kamishina, Yoshiaki Furukawa, Koji Yamanaka. Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation. The Journal of biological chemistry. 2023. 299. 6. 104798-104798
Yuzo Fujino, Morio Ueyama, Taro Ishiguro, Daisaku Ozawa, Toshihiko Sugiki, Hayato Ito, Asako Murata, Akira Ishiguro, Tania F. Gendron, Kohji Mori, et al. FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA inC9orf72-linked ALS/FTD. 2022
The Society of Biological Inorganic Chemistry
, THE CHEMICAL SOCIETY OF JAPAN
, THE JAPAN NEUROSCIENCE SOCIETY
, THE BIOPHYSICAL SOCIETY OF JAPAN
, PROTEIN SCIENCE SOCIETY OF JAPAN