Sugiyama Toru

スギヤマトオル | Sugiyama Toru

Affiliation and department：
Job title： associate professor
Homepage URL (1)： http://kaken.nii.ac.jp/ja/r/40242036

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (7)：ペプチド核酸 , RecA , PNA , 核酸化学 , 有機化学 , ペプチド化学 , ビタミンD

Research theme for competitive and other funds (19)：

2023 - 2027 Molecular design and synthesis of pseudo-complementary peptide nucleic acids capable of strand invasion without restriction
2023 - 2026 Analysis of novel peptide nucleic acids against neurodegeneration
2018 - 2021 アンチジーン法における配列制限の克服を目指したペプチド核酸の医薬分子設計
2012 - 2015 Study and development of a 14-epi-tachysterol skeleton and enhancing bone formation via flexibility of ligand binding domain of vitamin D receptor
2012 - 2015 アンチジーン医薬を指向した光学活性ペプチド核酸の医薬分子設計

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Papers (49)：

Yoshio Kusakabe, Shun-Suke Moriya, Toru Sugiyama, Yoshiki Miyata. Isolation and identification of the new baicalin target protein to develop flavonoid structure-based therapeutic agents. Bioorganic & medicinal chemistry. 2023. 90. 117362-117362
Shun-Suke Moriya, Kaoru Funaki, Yosuke Demizu, Masaaki Kurihara, Atsushi Kittaka, Toru Sugiyama. Synthesis and properties of PNA containing a dicationic nucleobase based on N4-benzoylated cytosine. Bioorganic & medicinal chemistry letters. 2023. 88. 129287-129287
森谷俊介, 米田有希, 桑田啓子, 今村保忠, 出水庸介, 栗原正明, 橘高敦史, 杉山亨. PreQ1塩基を持つペプチド核酸の合成とその性質. 日本薬学会年会要旨集. 2022. 142年会. 27PO3-05
Shun-suke Moriya, Yuki Yoneta, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Atsushi Kittaka, Toru Sugiyama. PreQ1 facilitates DNA strand invasion by PNA. Peptide Science. 2022. 2021. 111-112
Shun-suke Moriya, Hatsune Shibasaki, Misaki Kohara, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Atsushi Kittak, Toru Sugiyama. Synthesis and characterization of PNA oligomers containing preQ1 as a positively charged guanine analogue. Bioorganic and Medicinal Chemistry Letters. 2021. 39. 127850-127850

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MISC (10)：

森谷俊介, 大石真菜, 出水庸介, 栗原正明, 橘高敦史, 杉山亨. Cationic cytosine analogue of peptide nucleic acid monomer for enhanced DNA hybridization stability. 日本薬学会年会要旨集(Web). 2024. 144th
MORIYA Shun-suke, YONEZU Misaki, KONDO Yuzu, DEMIZU Yosuke, KURIHARA Masaaki, KITTAKA Atsushi, SUGIYAMA Toru. Synthesis of Dicationic Cytosine Derivative for Peptide Nucleic Acid. Peptide Science. 2023. 2022
森谷俊介, 米津実咲, 近藤有寿, 出水庸介, 栗原正明, 橘高敦史, 杉山亨. Synthesis of dicationic cytosine derivative for strand invasion with peptide nucleic acids. 日本薬学会年会要旨集(Web). 2023. 143rd
森谷俊介, 米田有希, 桑田啓子, 今村保忠, 出水庸介, 栗原正明, 橘高敦史, 杉山亨. Synthesis and properties of peptide nucleic acid consisting of preQ₁. 日本薬学会年会要旨集(Web). 2022. 142nd
森谷俊介, 桑田啓子, 今村保忠, 出水庸介, 栗原正明, 橘高敦史, 杉山亨. Strand-invasion of duplex DNA by peptide nucleic acid oligomers containing cationic guanine analogues. 日本薬学会年会要旨集(Web). 2021. 141st

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Lectures and oral presentations (30)：

新規カチオン性グアニンアナログをもつPNAオリゴマー
(日本薬学会第139年会 2019)
PNA Oligomers Possessing PreQ1 as a Cationic Analogue of Guanine
(10th International Peptide Symposium 2018)
正電荷を帯びたグアニン誘導体をもつPNAオリゴマーの合成
(第36回メディシナルケミストリーシンポジウム 2018)
β-アミノ酸を組み込んだ新規コラーゲン模倣物の創製
(第36回メディシナルケミストリーシンポジウム 2018)
電荷を帯びたグアニンアナログをもつPNAオリゴマーの合成
(第62回日本薬学会関東支部大会 2018)

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Education (2)：

1987 - 1992 東京大学大学院薬学系研究科製薬化学科
1983 - 1987 The University of Tokyo Faculty of Pharmaceutical Sciences Department of Pharmacy

Professional career (1)：

doctor of pharmacy (The University of Tokyo)

Work history (4)：

2015/04 - 現在 Teikyo University Faculty of Pharmaceutical Sciences associate professor
2007 - 2015/03 東京大学大学院・総合文化研究科助教
1992/08 - 2007/03 東京大学大学院総合文化研究科助手
1997/04 - 1999/03 米国エール大学博士研究員

Association Membership(s) (4)：

The Japanese Peptide Society , THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , THE CHEMICAL SOCIETY OF JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN

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