Nagao Motoshi

ナガオモトシ | Nagao Motoshi

Affiliation and department：
Job title：部長

Research field (4)： Cell biology , Neuroscience - general , Rehabilitation science , Developmental biology

Research keywords (10)：若返り , エピゲノム , エピジェネティック制御因子 , 転写因子 , 脳卒中 , 脊髄損傷 , オリゴデンドロサイト , アストロサイト , glia , neural stem cell

Research theme for competitive and other funds (10)：

2024 - 2027 エピゲノム操作を介したニューロン若返りによる脳卒中後のリハビリ促進法の開発
2022 - 2025 脳卒中後のリハレスポンダー増加のための反応性アストログリオーシス制御に関する研究
2022 - 2024 反応性アストロサイトの臨界期アストロサイト転換による慢性期脳卒中治療法の開発
2018 - 2022 Elucidation of mechanisms of motor function recovery after rehabilitation using glial transcriptome analysis.
2017 - 2020 The long term effect of rehabilitation effects on spastic symptoms

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Papers (36)：

Shuhei Murase, Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Ayumu Konno, Hirokazu Hirai, Taku Saito, Sakae Tanaka, Keisuke Shinohara, et al. Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans. Nature biomedical engineering. 2023. 7. 11. 1350-1373
Yasuhiro Sawada, Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Keisuke Shinohara, Takuya Kishi, Ayumu Konno, Hirokazu Hirai, Makoto Ayaori, et al. Brain- Targeted Mechanical Intervention Using Passive Head Motion Can Have an Antihypertensive Effect. CIRCULATION. 2022. 146
Takahiro Maekawa, Naoyoshi Sakitani, Youngjae Ryu, Atsushi Takashima, Shuhei Murase, Julius Fink, Motoshi Nagao, Toru Ogata, Masahiro Shinohara, Yasuhiro Sawada. Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents. Journal of Visualized Experiments. 2022. 185
Youngjae Ryu, Toru Ogata, Motoshi Nagao, Yasuhiro Sawada, Ryohei Nishimura, Naoki Fujita. Early escitalopram administration as a preemptive treatment strategy against spasticity after contusive spinal cord injury in rats. Scientific reports. 2021. 11. 1. 7120-7120
Youngjae Ryu, Takahiro Maekawa, Daisuke Yoshino, Naoyoshi Sakitani, Atsushi Takashima, Takenobu Inoue, Jun Suzurikawa, Jun Toyohara, Tetsuro Tago, Michiru Makuuchi, et al. Mechanical Regulation Underlies Effects of Exercise on Serotonin-Induced Signaling in the Prefrontal Cortex Neurons. iScience. 2020. 23. 2. 100874-100874

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MISC (3)：

Education (3)：

1997 - 2000 Tokyo Institute of Technology Bioscience and Biotechnology
1995 - 1997 東京工業大学大学院生命理工学研究科バイオサイエンス専攻修士課程
1991 - 1995 Tokyo Institute of Technology

Professional career (1)：

理学 (東京工業大学)

Work history (10)：

2023/07 - 現在厚生労働省国立障害者リハビリテーションセンター研究所脳機能系障害研究部部長
2023/04 - 現在厚生労働省国立障害者リハビリテーションセンター研究所運動機能系障害研究部神経機能再生研究室室長
2018/07 - 現在 National Rehabilitation Center for Persons with Disabilities, Research Institute
2013/04 - 2018/06 National Rehabilitation Center for Persons with Disabilities, Research Institute
2012/07 - 2013/03 The University of Tokyo Institute of Molecular and Cellular Biosciences Laboratory of Cell Signaling

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Association Membership(s) (3)：

日本ミエリン研究会 , グリア研究会 , Society for Neuroscience

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