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J-GLOBAL ID：201101033614192854   Update date: Apr. 03, 2025

Gotoh Yukiko

ゴトウ ユキコ | Gotoh Yukiko
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Affiliation and department：
The University of Tokyo Graduate School of Pharmaceutical Sciences

About The University of Tokyo Graduate School of Pharmaceutical Sciences


Homepage URL  (1)： http://kaken.nii.ac.jp/ja/r/70252525
Research field  (5)： Developmental biology ,  Cell biology ,  Systems genomics ,  Genomics ,  Neuroscience - general
Research keywords  (35)： 神経幹細胞 ,  アポトーシス ,  MAPキナーゼ ,  細胞運動 ,  カスペース ,  ニューロン ,  がん遺伝子 ,  神経細胞 ,  PI3キナーゼ ,  細胞生存 ,  細胞死 ,  細胞極性 ,  上皮間葉転換 ,  Scratch ,  増殖因子 ,  ニューロンサブタイプ ,  包括脳ネットワーク」 ,  JNK ,  MST1 ,  MAPKK ,  p38 ,  Bax ,  PDK1 ,  Mdm2 ,  SEKI ,  XMEK2 ,  Ras ,  MST ,  Cdc42 ,  Rho ,  actin, ,  増殖シグナル伝達 ,  PAK ,  AKT ,  生存シグナル
Research theme for competitive and other funds  (31)：
  • 2024 - 2029 神経の長期記憶を司るエピコードの解読
  • 2022 - 2028 脳損傷による記憶障害メカニズムの解析
  • 2022 - 2025 新規3Dゲノム構造同定法に基づいたニューロン分化・可塑性制御機構の解明
  • 2019 - 2025 Regulation of embryonic neural stem cells and its relation to postnatal brain development and autism spectrum disorder
  • 2021 - 2022 Interplay of developmental clock and extracellular environment in brain formation
Show all
Papers (179)：
  • Tomoya Kujirai, Kenta Echigoya, Yusuke Kishi, Mai Saeki, Tomoko Ito, Junko Kato, Lumi Negishi, Hiroshi Kimura, Hiroshi Masumoto, Yoshimasa Takizawa, et al. Structural insights into how DEK nucleosome binding facilitates H3K27 trimethylation in chromatin. Nature structural & molecular biology. 2025
  • Sarasa Yano, Natsu Asami, Yusuke Kishi, Ikuko Takeda, Hikari Kubotani, Yuki Hattori, Ayako Kitazawa, Kanehiro Hayashi, Ken-ichiro Kubo, Mai Saeki, et al. Propagation of neuronal micronuclei regulates microglial characteristics. Nature Neuroscience. 2025. 28. 3. 487-498
  • Merve Bilgic, Yukiko Gotoh, Yusuke Kishi. Age-associated transcriptomic and epigenetic alterations in mouse hippocampus. 2024
  • Seishin Sakai, Yurie Maeda, Keita Kawaji, Yutaka Suzuki, Yukiko Gotoh, Yusuke Kishi. In vivo transition in chromatin accessibility during differentiation of deep-layer excitatory neurons in the neocortex. 2024
  • Tianyi Hideyuki Shi, Hiroki Sugishita, Yukiko Gotoh. Crosstalk within and beyond the Polycomb repressive system. Journal of Cell Biology. 2024. 223. 5
ｍore...
MISC (41)：
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Lectures and oral presentations  (476)：
  • HMGA2 directly mediates chromatin condensation in association with neuronal fate regulation
    (Cold Spring Harbor Conferences Asia Cold Spring Harbor Laboratory, Chromatin, Epigenetics & Transcription 2024)
  • Regulation of cell fate choice
    (The 101st Annual Meeting of The Physiological Society of Japan 2024)
  • 胎生期神経幹細胞でのニューロン産生期からグリア産生期への移行における小胞体ストレスの関与
    (第17回神経発生討論会 2024)
  • FGF関連遺伝子が成体神経幹細胞の形成・維持に貢献する
    (第17回神経発生討論会 2024)
  • 成体神経幹細胞と上衣細胞の胎生期起源細胞の同定と形成機構の解明
    (第17回神経発生討論会 2024)
ｍore...
Work history (4)：
  • 2017/10 - 現在 The University of Tokyo International Research Center for Neurointelligence Principal Investigator
  • 2013/10 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2005/04 - 2013/09 The University of Tokyo Institute of Molecular and Cellular Biosciences
  • 1998/04 - 2005/03 The University of Tokyo Institute of Molecular and Cellular Biosciences
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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