2016 - 2019 Analysis of molecular mechanism of pathogenesis from disturbance of cell polarity caused by oxidative stress response
2015 - 2018 Regulatory mechanism of hair follicle stem cell quiescence by cell polariry protein aPKC
2011 - 2016 Regulation of cell polarity and cell fates in tissue stem/progenitor cells
2009 - 2014 A study on the regulatory mechanisms of mammalian early embryogenesis trough the evolutionarily conserved cell polarity regulating system
2010 - 2012 Molecular mechanisms of the polarity-regulating signaling
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Papers (45):
Shields MA, Metropulos AE, Spaulding C, Alzahrani KA, Hirose T, Ohno S, Pham TND, Munshi HG. BET Inhibition Rescues Acinar-Ductal-Metaplasia and Ciliogenesis and Ameliorates Chronic Pancreatitis-Driven Changes in Mice With Loss of the Polarity Protein Par3. Cellular and molecular gastroenterology and hepatology. 2024
Kazuki Furugori, Hidefumi Suzuki, Ryota Abe, Keiko Horiuchi, Tomohiko Akiyama, Tomonori Hirose, Atsushi Toyoda, Hidehisa Takahashi. Chimera RNA transcribed from integrated HPV18 genome with adjacent host genomic region promotes oncogenic gene expression through condensate formation. Genes to cells : devoted to molecular & cellular mechanisms. 2024
Mario A Shields, Anastasia E Metropulos, Christina Spaulding, Tomonori Hirose, Shigeo Ohno, Thao N D Pham, Hidayatullah G Munshi. BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss. bioRxiv : the preprint server for biology. 2023
Tomonori Hirose, Sugitani Y, Hidetake Kurihara, Hiromi Kazama, Kusaka C, Noda T, Hidehisa Takahashi, Shigeo Ohno. PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling. Development (Cambridge, England). 2022. 149. 21
Hidefumi Suzuki, Ryota Abe, Miho Shimada, Tomonori Hirose, Hiroko Hirose, Keisuke Noguchi, Yoko Ike, Nanami Yasui, Kazuki Furugori, Yuki Yamaguchi, et al. The 3' Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies' association with histone locus bodies. Nature communications. 2022. 13. 1. 2905-2905
S. Osada, N. Noguchi, T. Hirose, T. Suzuki, M. Kagaya, K. Chida, S. Ohno, M. Manabe. Differential roles of atypical protein kinase C isoforms in wound healing. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017. 137. 10. S306-S306