Hirose Tomonori

Affiliation and department：
Job title： Lecturer
Homepage URL (1)： https://ycu-molecularbiology.jp/

Research field (6)： Neuroscience - general , Developmental biology , Molecular biology , Anatomy , Nephrology , Pathobiochemistry

Research keywords (20)：神経幹細胞 , hedgehog signaling , primary cilia , PAR3 , ノックアウトマウス , 細胞極性 , 細胞分化 , 非対称分裂 , ポドサイト , 腎臓病 , 疾患モデルマウス , 心外膜前駆細胞 , 上皮細胞 , ASPP2 , ASIP , aPKC , PAR6 , シグナル伝達 , 糸球体疾患 , 包括脳ネットワーク

Research theme for competitive and other funds (7)：

2023 - 2026 精原幹細胞の同期的な分化制御における統合的かつ同調的な遺伝子発現調節機構の解明
2020 - 2023 大脳皮質形成における霊長類型の神経幹細胞産生に関わる遺伝子の網羅的探索
2016 - 2019 Analysis of molecular mechanism of pathogenesis from disturbance of cell polarity caused by oxidative stress response
2015 - 2018 Regulatory mechanism of hair follicle stem cell quiescence by cell polariry protein aPKC
2011 - 2016 Regulation of cell polarity and cell fates in tissue stem/progenitor cells

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Papers (44)：

Kazuki Furugori, Hidefumi Suzuki, Ryota Abe, Keiko Horiuchi, Tomohiko Akiyama, Tomonori Hirose, Atsushi Toyoda, Hidehisa Takahashi. Chimera RNA transcribed from integrated HPV18 genome with adjacent host genomic region promotes oncogenic gene expression through condensate formation. Genes to cells : devoted to molecular & cellular mechanisms. 2024
Mario A Shields, Anastasia E Metropulos, Christina Spaulding, Tomonori Hirose, Shigeo Ohno, Thao N D Pham, Hidayatullah G Munshi. BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss. bioRxiv : the preprint server for biology. 2023
Tomonori Hirose, Yoshinobu Sugitani, Hidetake Kurihara, Hiromi Kazama, Chiho Kusaka, Tetsuo Noda, Hidehisa Takahashi, Shigeo Ohno. PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling. Development. 2022. 149. 21
Hidefumi Suzuki, Ryota Abe, Miho Shimada, Tomonori Hirose, Hiroko Hirose, Keisuke Noguchi, Yoko Ike, Nanami Yasui, Kazuki Furugori, Yuki Yamaguchi, et al. The 3' Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies' association with histone locus bodies. Nature communications. 2022. 13. 1. 2905-2905
Yunan Wang, Hiroyuki Kitahata, Hideyuki Kosumi, Mika Watanabe, Yu Fujimura, Shota Takashima, Shin-Ichi Osada, Tomonori Hirose, Wataru Nishie, Masaharu Nagayama, et al. Collagen XVII deficiency alters epidermal patterning. Laboratory investigation; a journal of technical methods and pathology. 2022. 102. 6. 581-588

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MISC (24)：

S. Osada, N. Noguchi, T. Hirose, T. Suzuki, M. Kagaya, K. Chida, S. Ohno, M. Manabe. Differential roles of atypical protein kinase C isoforms in wound healing. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017. 137. 10. S306-S306
瀬古大暉, 北嶋康雄, 廣瀬智威, 秋本憲和, 大野茂男, 小野悠介. 筋サテライト細胞における細胞極性因子PAR3およびPKCiotaの役割. 日本生化学会大会(Web). 2017. 90th. ROMBUNNO.2LBA-089 (WEB ONLY)
廣瀬智威, 廣瀬智威, 風間宏美, 野田哲生, 大野茂男. 神経上皮細胞の一次繊毛におけるヘッジホッグ・シグナル伝達系の調節機構に対するPAR3の役割. 日本生化学会大会(Web). 2017. 90th. ROMBUNNO.3LBA-071 (WEB ONLY)-071]
廣瀬智威, 風間宏美, 藤田龍平, 大野茂男. 一次繊毛におけるヘッジホッグ・シグナル伝達系の調節機構に対する細胞極性制御因子の関係. 日本生化学会大会(Web). 2015. 88th. 3P0193 (WEB ONLY)-[3P0193]
The role of cell-polarity proteins in the maintenance of glomerular podocytes. 2012. 63. 3. 243-250

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Lectures and oral presentations (2)：

PAR3 restricts the expansion of neural precursor cells by regulating hedgehog signaling
(2022)
教育講演:様々な細胞の極性を制御する共通分子機構
(第85回日本皮膚科学会東京支部学術大会 2021)

Professional career (1)：

医学博士 (横浜市立大学)

Committee career (1)：

2015/04 - 現在横浜市立大学医学部医学科医学教育分野別認証評価準備委員会

Awards (1)：

2011/04 - 横浜市立大学医学会医学研究奨励賞

Association Membership(s) (2)：

THE JAPANESE BIOCHEMICAL SOCIETY , The Molecular Biology Society of Japan

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