HARA Yoshinobu

Affiliation and department：
Job title： instructor

Research field (1)： Neuroanatomy and physiology

Research keywords (4)：層形成 , 細胞移動 , 大脳皮質 , 包括脳ネットワーク

Research theme for competitive and other funds (7)：

2023 - 2026 移動神経細胞におけるサイトへジン2-Arf6小胞輸送経路活性化制御機構の解明
2020 - 2023 サイトへジン2-Arf6小胞輸送経路を介した神経細胞の移動制御機構の解明
2015 - 2019 Molecular anatomy of photoreceptor ribbon synapses with special attention to the ADP ribosylation factor 6 (Arf6) pathway
2014 - 2017 Participation of LRP4 receptor which is indispensable to neuromuscular junctions in central nervous system
2010 - 2014 Functional analysis of the BRAG3-Arf6 pathway in the inhibitory synapse

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Papers (29)：

Hiroyuki Sakagami, Tomoko Shiroshima, Noriko Nemoto, Tomoko Niimura, Takeyuki Sugawara, Yoshinobu Hara, Koji Saito, Tadashi Okubo, Masahiro Fukaya. Disruption of Iqsec1 in mice leads to embryonic lethality with reduced large apical vacuoles in the visceral endoderm. FEBS Letters. 2024
Masahiro Fukaya, Kanta Ibuchi, Takeyuki Sugawara, Makoto Itakura, Akiko Ito, Tomoko Shiroshima, Yoshinobu Hara, Hirotsugu Okamoto, Frédéric Luton, Hiroyuki Sakagami. EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells. Traffic. 2024. 25. 5
Yoshinobu Hara, Takehiko Katsuyama, Masahiro Fukaya, Takeyuki Sugawara, Tomoko Shiroshima, Tetsushi Sadakata, Noriko Osumi, Hiroyuki Sakagami. ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through N-Cadherin Trafficking during Cerebral Cortical Development. eneuro. 2023. 10. 11. ENEURO.0125-23.2023
Akiko Ito, Masahiro Fukaya, Takeyuki Sugawara, Yoshinobu Hara, Hirotsugu Okamoto, Junji Yamauchi, Hiroyuki Sakagami. Cytohesin-2 mediates group I metabotropic glutamate receptor-dependent mechanical allodynia through the activation of ADP ribosylation factor 6 in the spinal cord. Neurobiology of Disease. 2021. 159. 105466-105466
Ryo Nishinarita, Shinichi Niwano, Hiroe Niwano, Hironori Nakamura, Daiki Saito, Tetsuro Sato, Gen Matsuura, Yuki Arakawa, Shuhei Kobayashi, Yuki Shirakawa, et al. Canagliflozin Suppresses Atrial Remodeling in a Canine Atrial Fibrillation Model. Journal of the American Heart Association. 2021. 10. 2. e017483

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MISC (9)：

Yoshinobu Hara, Nobuhiko Nishimura, Masahiro Fukaya, Hiroyuki Sakagami. Expression and functional roles of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) gamma in the developing cerebral cortex. NEUROSCIENCE RESEARCH. 2011. 71. E128-E128
Masahiro Fukaya, Yoshinobu Hara, Hiroyuki Sakagami. Postsynaptic and endosomal localization of BRAG2/GEP100 in the adult mouse brain. NEUROSCIENCE RESEARCH. 2011. 71. E321-E321
Kaichi Yoshizaki, Yoshinobu Hara, Hideaki Wakita, Noriko Osumi. Influence of chronic cerebral hypoperfusion on depressive phenotypes. NEUROSCIENCE RESEARCH. 2009. 65. S255-S255
前川素子, 高嶋記子, 松股美穂, 池上司郎, 紺谷昌仙, 原芳伸, 河島洋, 大和田祐二, 吉川武男, 湯浅茂樹, et al. 神経化学と精神医学の融合による精神疾患病態解明・治療法開発モデルラットにおいてアラキドン酸は神経新生を増大させ、プレパレス抑制を回復させる(Arachidonic acid increases neurogenesis and restores prepulse inhibition deficits in model rats). 神経化学. 2008. 47. 2-3. 207-207
Yoshinobu Hara, Frisen Jonas, Noriko Osumi. The function of Ephrin-Eph signaling in postnatal neurogenesis. NEUROSCIENCE RESEARCH. 2008. 61. S27-S27

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Professional career (1)：

Ph.D.

Work history (4)：

2021/01 - 現在 Kitasato University School of Medicine, Department of Anatomy
2009/05 - 2020/12 Kitasato University School of Medicine
2016/09 - 2017/08 Max Planck institute Cell Biology and Genetics Wieland Huttner lab. visiting researcher
2005/04 - 2009/04 Tohoku University Graduate School of Medicine

Association Membership(s) (2)：

THE JAPANESE ASSOCIATION OF ANATOMISTS , 日本神経科学会

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