2018 - 2021 Analysis of the molecular mechanism of circadian clock and cerebral insulin resistance involving in beta-amyloid deposition
2015 - 2018 Investigation of mechanisms of inflammatory bowel disease caused by interaction of high-fat diet and LRRK2, a susceptibility gene of IBD
2013 - 2016 Clarification of autophagy mechanisms to tracking from exocrine secretory granule membrane
2010 - 2012 Antioxidant induced decrement of β-amyloid deposits by phase contrast X-ray technique
2010 - 2012 Characterization of LRRK2 in enteric nervous system
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Papers (41)：
Hiroko P. Indo, Moragot Chatatikun, Ikuo Nakanishi, Ken-ichiro Matsumoto, Motoki Imai, Fumitaka Kawakami, Makoto Kubo, Hiroshi Abe, Hiroshi Ichikawa, Yoshikazu Yonei, et al. The Roles of Mitochondria in Human Being’s Life and Aging. Biomolecules. 2024. 14. 10. 1317-1317
Yoshifumi Kurosaki, Toshihide Matsumoto, Takayuki Uematsu, Fumitaka Kawakami, Rei Kawashima, Shun Tamaki, Motoki Imai, Takafumi Ichikawa, Naohito Ishii, Hidero Kitasato, et al. SARS-CoV-2 infection causes a decline in renal megalin expression and affects vitamin D metabolism in the kidney of K18-hACE2 mice. Scientific reports. 2024. 14. 1. 24313-24313
Daisuke Masuda, Ikuo Nakanishi, Kei Ohkubo, Hiromu Ito, Ken-ichiro Matsumoto, Hiroshi Ichikawa, Moragot Chatatikun, Wiyada Kwanhian Klangbud, Manas Kotepui, Motoki Imai, et al. Mitochondria Play Essential Roles in Intracellular Protection against Oxidative Stress-Which Molecules among the ROS Generated in the Mitochondria Can Escape the Mitochondria and Contribute to Signal Activation in Cytosol?. Biomolecules. 2024. 14. 1. 128-128
Motoki Imai, Fumitaka Kawakami, Takayuki Uematsu, Toshihide Matsumoto, Rei Kawashima, Yoshifumi Kurosaki, Shun Tamaki, Shotaro Maehana, Takafumi Ichikawa, Hideaki Hanaki, et al. SARS-CoV-2 propagation to the TPH2-positive neurons in the ventral tegmental area induces cell death via GSK3β-dependent accumulation of phosphorylated tau. PloS one. 2024. 19. 10. e0312834
Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark R. Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J. Farrer, Makoto Kanzaki, Rei Kawashima, Tatsunori Maekawa, et al. LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes. FEBS Open Bio. 2023
坪川大悟, 佐藤雅, 川上文貴, 川島麗, 市川尊文. The regulation mechanism of intestinal immune responses via RAGE during the parasitic nematode infection. 日本寄生虫学会大会プログラム・抄録集. 2023. 92nd
坪川大悟, 佐藤雅, 川上文貴, 川島麗, 市川尊文. The role of RAGE in susceptibility to Nippostrongylus brasiliensis infection. 日本寄生虫学会大会プログラム・抄録集. 2022. 91st
