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Rchr

J-GLOBAL ID：201101046315928920 Update date: Feb. 15, 2025

NAKANO MIYAKO

ナカノミヤコ | NAKANO MIYAKO

Affiliation and department：
Job title：准教授

Research field (2)： Pharmaceuticals - health and biochemistry , Pharmacology

Research keywords (5)： cancer, tumor , biomarker , glycoprotein , mass spectrometry , glycan analysis

Research theme for competitive and other funds (19)：

2022 - 2024 N-型糖転移酵素による標的分子修飾の特異性と糖鎖の書き換え
2022 - 2023 糖鎖の分岐形成によるがん・アルツハイマー病の悪性化メカニズム
2020 - 2023 Mechanisms of cancer and Alzheimer's disease involving glycan branching
2019 - 2023 糖脂質リモデリングによる蛋白質のソーティング機構
2022 - 2022 がんおよび神経疾患に関連するN型糖鎖のグライコーム解析(継続)

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Papers (99)：

Roh T, Ju S, Park SY, Ahn Y, Chung J, Nakano M, Ryu G, Kim YJ, Kim G, Choi H, Lee SG, Kim IS, Lee SI, Chung C, Shimizu T, Miyoshi E, Jung SS, Park C, Yamasaki S, Park SY, Jo EK. Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study. Nat Commun. 2025. 16. 1. 1342
Bao W, Yamasaki T, Nakano M, Nagae M, Kizuka Y. Functions of unique middle loop and C-terminal tail in GnT-III activity and secretion. Biochim Biophys Acta Gen Subj. 2025. 1869. 1. 130734
Honda, Akinobu, Seino, Junichi, Huang, Chengcheng, Nakano, Miyako, Suzuki, Tadashi. Occurrence of free glycans in salmonid serum. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2025. 742
Naoki Morishima, Maki Iwaisako, Yoshihiro Kamada, Miyako Nakano, Masafumi Shiida, Tatsuya Ono, Reika Sonoda, Risa Uemura, Daisuke Sakon, Munefumi Shimosaka, et al. Generation and validation of antibody 42B1 recognizing galactose-deficient IgG for diagnosis of chronic inflammatory diseases. Clinica chimica acta; international journal of clinical chemistry. 2024. 566. 120052-120052
Osada, Naoko, Mishra, Sushil K., Nakano, Miyako, Tokoro, Yuko, Nagae, Masamichi, Doerksen, Robert J., Kizuka, Yasuhiko. Self-regulation of MGAT4A and MGAT4B activity toward glycoproteins through interaction of lectin domain with their own N-glycans. ISCIENCE. 2024. 27. 11

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MISC (43)：

長田菜緒子, 長江雅倫, 長江雅倫, 中の三弥子, MISHRA Sushil K., DOERKSEN Robert J., 木塚康彦, 木塚康彦. Recognition of self N-glycan by lectin domain of GnT-IV glycosyltransferase. 日本糖質学会年会要旨集. 2023. 42nd
橋本雄太, 川出遥加, 森井爽, 中の三弥子, 長江雅倫, 長江雅倫, 木塚康彦, 木塚康彦. Analysis of the regulatory mechanisms of intracellular activity of GnT-III K346T mutant. 日本糖質学会年会要旨集. 2023. 42nd
大川祐樹, 中野可菜, 貫戸紀子, 中の三弥子, 三善英知, 原田陽一郎, 谷口直之. 細胞外環境により発現誘導されるバイセクト型糖鎖はがんの悪性形質を増強する. 日本癌学会総会記事. 2021. 80回. [J11-4]
近藤清貴, 原田陽一郎, 水野圭子, 谷口直之, 金蔵拓郎, 堂前直, 中ノ三弥子, 井上博雅. 細胞外小胞のN結合型糖鎖構修飾されたタンパクの解析により肺癌の組織型を診断できる. 日本癌学会総会記事. 2021. 80回. [P14-6]
大川祐樹, 中野可菜, 貫戸紀子, 中の三弥子, 三善英知, 原田陽一郎, 谷口直之. 細胞外環境により発現誘導されるバイセクト型糖鎖はがんの悪性形質を増強する. 日本癌学会総会記事. 2021. 80回. [J11-4]

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Patents (2)：

膵臓癌マーカーおよび膵臓癌の検査方法
糖たん白質糖鎖の分析方法及び非標識糖鎖の製造方法

Books (6)：

Glycoscience Protocols (GlycoPODv2) [Internet]
NIH 2021
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Glycan Biomarkers in Pancreatic Cancer".
Elsevier 2020
ファルマシア55巻09号トピック G群環境・衛生分野
日本薬学会 2019
Glycoscience: Basic Science to Applications - Insights from the Japan Consortium for Glycobiology and Glycotechnology
Springr Nature 2019
未来を創るグライコサイエンスー我が国のロードマップ-
日本糖鎖科学コンソーシアム 2018

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Lectures and oral presentations (60)：

Glycoproteomic analysis for identification of glycosites for GnT-V reaction
(Glyco-core Symposium 2024 2024)
Glycoprotoemic and Glycomic analysis of haptoglobin: possible implication for the differential diagnosis of cancer
(Korean Human Proteome Organization 2024 (KHUPO2024) 2024)
糖転移酵素GnT IV のレクチンドメインによる自己N 型糖鎖の認識
(第42回日本糖質学会年会 2023)
糖転移酵素GnT III K346T 変異体の細胞内における活性制御機構の解析
(第42回日本糖質学会年会 2023)
マウス腎臓における糖転移酵素GnT-V の基質糖タンパク質の認識機構
(第42回日本糖質学会年会 2023)

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Education (4)：

2001 - 2004 Kindai University
2001 - 2002 Johns Hopkins University Biology Dept. Exchange student for collaboration researchch
1997 - 1999 Kindai University
1992 - 1997 Kindai University

Professional career (2)：

Doctor of Philosophy in Pharmaceutical Science (Kindai University)
Master of Pharmaceutical Science (Kindai University)

Work history (8)：

2021/09/01 - Osaka International Cancer Institute Visiting researcher
2021/07/01 - The Japanese Society of Carbohydrate Research board member
2019/04/01 - Kumamoto University Visiting lecturer
2019/04/01 - Hiroshima University Graduate School of Integrated Sciences for Life Associate Professor
2012/06/01 - 2019/03/31 Hiroshima University Graduate School of Advanced Sciences of Matter Associate Professor

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Awards (4)：

2017/11/04 - Hirohima University Phoenix Outstanding Researcher Award
2014/09/17 - 日本分析化学会展望とトピック賞糖鎖で癌、抗癌剤の効き目がわかる
2013 - 広島大学広島大学女性研究者奨励賞
2005/07/20 - Japanese Carbohydrate Symposium Poster award Analysis of fluorescent labeled N-glycans by on-line ESI MS

Association Membership(s) (6)：

The Mass Spectrometry Society of Japan , Human Proteome Organization (HUPO) , The Japan Society for Analytical Chemistry , The Japanese Cancer Association , The Japanese Society of Carbohydrate Research , The Pharmaceutical Society of Japan

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