Rchr
J-GLOBAL ID:201101047912443941
Update date: Jun. 24, 2024
SAKAI Hiroshi
SAKAI Hiroshi
Affiliation and department:
Job title:
Assistant Professor
Homepage URL (1):
https://nrid.nii.ac.jp/ja/nrid/1000000820804/
Research field (1):
Sports science
Research keywords (14):
Skeletal muscle
, Androgens
, Androgen
, Androgen receptor
, Muscle stem cells
, Mesenchymal progenitors
, Muscle hypertrophy
, Muscle atrophy
, Muscle regeneration
, Regenerative medicine
, Muscular dystrophy
, Cell therapy
, Notch
, Myology
Research theme for competitive and other funds (17):
- 2024 - 2027 Functional elucidation of Mybph, a novel factor with inhibitory effects on skeletal muscle hypertrophy for the prevention of muscle atrophy.
- 2023 - 2026 敗血症モデルマウスを用いた骨格筋萎縮機序解明と急性期栄養介入法の探索
- 2023 - 2025 Uncovering Novel Factors for Sustained Skeletal Muscle Health and Longevity, with Implications for Drug Development
- 2023 - 2025 Functional elucidation of novel factors that maintain and enhance skeletal muscle for prevention of muscle atrophy and their application to drug discovery
- 2022 - 2025 Functional analysis of the RNA-binding protein Acin1 as a therapeutic target for sarcopenia.
- 2023 - 2024 Omics Analysis of Skeletal Muscle Regulatory Mechanisms Induced by Male Hormone
- 2021 - 2024 アンドロゲン減少による骨格筋外組織からの骨格筋量の制御メカニズムの基盤的研究
- 2020 - 2024 Integrated analysis of androgen receptor target genes in skeletal muscles for preventing sarcopenia
- 2021 - 2023 Elucidation of the molecular mechanism of the effect of androgens on the maintenance and the hypertrophy of skeletal muscle mass.
- 2020 - 2023 国際交流経費
- 2020 - 2022 スタートアップ経費
- 2020 - 2022 Integrated analysis of androgen receptor target genes in skeletal muscles for preventing sarcopenia
- 2019 - 2021 Elucidation of the mechanism of androgen regulation of skeletal muscle using integrative analysis
- 2018 - 2021 テニュア教員育成期間の財政的支援(研究費の配分)
- 2018 - 2020 Integrated analysis of androgen signaling in skeletal muscles.
- 2018 - 2019 Integrated analysis of androgen signaling in skeletal muscles.
- 2018 - 2019 Study of skeletal muscle stem cells for treatment of DMD.
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Papers (19):
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Hiroshi Sakai, Hideaki Uno, Harumi Yamakawa, Kaori Tanaka, Aoi Ikedo, Akiyoshi Uezumi, Yasuyuki Ohkawa, Yuuki Imai. The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice. bioRxiv. 2024
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Hiroshi Sakai, Yuuki Imai. Cell-specific functions of androgen receptor in skeletal muscles. Endocrine Journal. 2024
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Hiroshi Sakai, Yuichiro Sawada, Naohito Tokunaga, Kaori Tanaka, So Nakagawa, Iori Sakakibara, Yusuke Ono, So-ichiro Fukada, Yasuyuki Ohkawa, Tadahiko Kikugawa, et al. Uhrf1 governs the proliferation and differentiation of muscle satellite cells. iScience. 2022. 25. 3. 103928-103928
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Iori Sakakibara, Yuta Yanagihara, Koichi Himori, Takashi Yamada, Hiroshi Sakai, Yuichiro Sawada, Hirotaka Takahashi, Noritaka Saeki, Hiroyuki Hirakawa, Atsushi Yokoyama, et al. Myofiber androgen receptor increases muscle strength mediated by a skeletal muscle splicing variant of Mylk4. iScience. 2021. 24. 4. 102303-102303
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Hiroyuki Iio, Tadahiko Kikugawa, Yuichiro Sawada, Hiroshi Sakai, Shuhei Yoshida, Yuta Yanagihara, Aoi Ikedo, Noritaka Saeki, So-ichiro Fukada, Takashi Saika, et al. DNA maintenance methylation enzyme Dnmt1 in satellite cells is essential for muscle regeneration. Biochemical and Biophysical Research Communications. 2021. 534. 79-85
more...
MISC (1):
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Hiroshi Sakai, Yuuki Imai. Androgen action on skeletal muscles. EHIME MEDICAL JOURNAL. 2023. 42. 6. 45-48
Lectures and oral presentations (47):
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INVESTIGATION OF NUTRITIONAL THERAPY TO IMPROVE SEPSIS-INDUCED SKELETAL MUSCLE WEAKNESS
(The 47th Annual Conference On Shock 2024)
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The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice
(2024)
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The androgen receptor in myofibers regulates contraction-related genes in skeletal muscle
(2024)
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The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice.
(The 8th Annual Meeting of the Society of Skeletal Muscle Cells for Young Scientists 2024)
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Androgen receptor in mesenchymal progenitors is important for skeletal muscles in adult male mice.
(The 21st Protein Island Matsuyama International Symposium (PIM2023) 2023)
more...
Education (2):
- 2008 - 2012 Kyoto University Graduate School of Medicine Department of Medicine
- 2002 - 2008 Azabu Universtiy Department of Veterinary Medicine
Professional career (1):
Work history (11):
- 2021/04 - 現在 Ehime University Proteo-Science Center Assistant Professor
- 2020/04 - 現在 HIRAKU-Global Faculty Members FY2020
- 2018/04 - 2021/03 Ehime University Proteo-Science Center Assistant professor (Tenure track)
- 2018/02 - 2018/06 Institut Pasteur Stem Cells And Development Visiting Researcher
- 2018/02 - 2018/03 Ehime University Proteo-Science Center Assistant Professor
- 2013/06 - 2018/01 Institut Pasteur Stem Cells And Development Postdoctoral Fellow
- 2013/06 - 2014/06 Institut Pasteur Stem Cells And Development Postdoctoral fellow
- 2013/04 - 2013/05 Kyoto University Institute for Frontier Medical Sciences Assistant Teaching Staff
- 2012/09 - 2013/03 Kyoto University Graduate School of Medicine Associate Fellow
- 2012/05 - 2012/08 Kyoto University Center for iPS Cell Research and Application Assistant Teaching Staff
- 2012/04 - 2012/04 Kyoto University Institute for Frontier Medical Sciences Assistant Teaching Staff
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Committee career (3):
- 2024/03 - 現在 HIRAKU-Global Retreat FY2024 Co-organizer
- 2021/08 - 現在 PHC Corporation Member of the Biosafety Committee and Member of the Genetic Modification Safety Committee
- 2022/08 - 2023/08 The 9th Annual Meeting of Japan Muscle Society Symposium Committee
Awards (3):
- 2024/05 - Joint Meeting of Muscle, Bone and Rheumatology Societies Outstanding Theme Award
- 2021/12 - The 7th Annual Meeting of Japan Muscle Society Young Investigator Award (YIA) Grand Prize
- 2011/09 - Kyoto University Global COE "Center for Frontier Medicine" International Symposium/Retreat 2011 “the Best Poster Award”
Association Membership(s) (2):
Japanese Society of Physical Fitness and Sports Medicine
, Japan Muscle Society
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