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J-GLOBAL ID：201101054826409362   Update date: Feb. 01, 2024

Yasuyuki Nagumo

Yasuyuki Nagumo
Affiliation and department：
National Cancer Center Division of Cancer Pathophysiology

About National Cancer Center Division of Cancer Pathophysiology


Research field  (2)： Tumor biology ,  Neuroscience - general
Research keywords  (1)： 包括脳ネットワーク
Research theme for competitive and other funds  (6)：
  • 2021 - 2024 Construction of morphinan-based focused library
  • 2021 - 2024 独自開発新規κオピオイド受容体作動薬の疼痛緩和医療適用を目指した基盤研究
  • 2020 - 2023 Development of novel selective orexin 1 receptor agonists and elucidation of the function of orexin receptors
  • 2020 - 2023 Development of novel PET probes targeting orexin 1 receptor
  • 2015 - 2017 末梢神経損傷による視床シナプス外部GABA電流の変化と視床神経回路改編への影響
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Papers (47)：
  • Kenta Maeda, Sayaka Ohrui, Akihisa Tokuda, Yasuyuki Nagumo, Naoshi Yamamoto, Ryuji Tanimura, Tsuyoshi Saitoh, Noriki Kutsumura, Hiroshi Nagase. Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton. Organic letters. 2023. 25. 19. 3407-3411
  • Keita Iio, Kao Hashimoto, Yasuyuki Nagumo, Mao Amezawa, Taisei Hasegawa, Naoshi Yamamoto, Noriki Kutsumura, Katsuhiko Takeuchi, Yukiko Ishikawa, Hikari Yamamoto, et al. Design and Synthesis of Orexin 1 Receptor-Selective Agonists. Journal of medicinal chemistry. 2023. 66. 8. 5453-5464
  • Kenichi Tanaka, Naoko Kuzumaki, Yusuke Hamada, Yukari Suda, Tomohisa Mori, Yasuyuki Nagumo, Minoru Narita. Elucidation of the mechanisms of exercise-induced hypoalgesia and pain prolongation due to physical stress and the restriction of movement. Neurobiology of pain (Cambridge, Mass.). 2023. 14. 100133-100133
  • Tsuyoshi Saitoh, Mao Amezawa, Jumpei Horiuchi, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Ryuichiro Ohshita, Akihisa Tokuda, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, et al. Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library. European journal of medicinal chemistry. 2022. 240. 114505-114505
  • Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, et al. Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring. Bioorganic & medicinal chemistry letters. 2022. 60. 128555-128555
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MISC (27)：
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Patents (1)：
  • <産業財産権・特許>特願 2016-155477,モルヒナン誘導体及びその医薬用途
Books (1)：
  • トワイクロス先生のがん緩和ケア処方薬 : 薬効・薬理と薬の使い方
    医学書院 2013 ISBN:9784260015219
Professional career (1)：
  • 薬学博士 (星薬科大学)
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