Research theme for competitive and other funds (21)：
2022 - 2025 Development of next-generation pharmaceuticals through evolutionary engineering of p recision polymers
2022 - 2025 Precision macromolecular evolution system combined use of nucleic acid and high-precision separation methods
2019 - 2023 機能発現・判別を指向するDNAアプタマーの電気泳動選抜
2020 - 2023 血液凝固因子を標的とする中和可能な核酸アプタマー創薬基盤技術の開発
2018 - 2023 超高感度センサシステムの研究開発
2018 - 2021 Introduction and evaluation of micro beads-assisted capillary electrophoresis for nucleic acid aptamer selection systems
2016 - 2020 Nucleic acid aptamer scaffolds for stem cell fate control
2016 - 2019 Rapid selection of DNA aptamers recognizing cell surface using capillary electrophoresis
2016 - 2019 Design of biomaterials for treatment of spinal cord injury
2015 - 2018 Development of next-generation technologies for bone-cartilage regeneration on the basis of Raman profiling for regenerated bones and cartilages
2017 - 2018 薬剤探索支援の事業化を目的とする薬剤候補分子の高効率な分離改善技術の検証
2015 - 2017 Development of DEP device for analysis of mechanobiology that affects cell function and differentiation
2012 - 2015 Development of theree-dimentional cell culture chip for drug screening
2014 - 2015 細胞表面抗原に結合して蛍光応答を発する診断用核酸アプタマーの創製
2008 - 2012 Construction of Densely Packed Hybrid Biointerfase
2011 - 2011 ヒト脂肪幹細胞をソースとする肝細胞スフェロイドチップの開発
2010 - 2011 Development of functional cell array for long-term survival and recovery of tissues
2008 - 2009 Development of hydrogen-bonding lanthanide complex that recognizes nucleic acid base and Its application for the determination of DNA sequence
2007 - 2008 遺伝子センシングを可能とするバイオナノ粒子の材料設計
2006 - 2008 Bionanosensing based on Bio-frontier Surface
2005 - 2006 核酸の光機能化に基づく新規バイオセンサーの開発と細胞分析基板技術への応用
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Papers (74)：
Muneyuki Matsuo, Koji Wakui, Yuuki Inami, Akihiro Furukawa, Seiji Sato, Keitaro Yoshimoto. Proficiently partitioning of bioactive peptide-ssDNA conjugates by microbead-assisted capillary electrophoresis (MACE). Analytical Biochemistry. 2023. 115452-115452
Masanobu Nagano, Kazuki Kubota, Asuka Sakata, Rei Nakamura, Toru Yoshitomi, Koji Wakui, Keitaro Yoshimoto. A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice. Molecular Therapy-Nucleic Acids. 2023. 33. 762-772
Romualdo Troisi, Valeria Napolitano, Emanuele Rossitto, Waleed Osman, Masanobu Nagano, Koji Wakui, Grzegorz M Popowicz, Keitaro Yoshimoto, Filomena Sica. Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide. Nucleic Acids Research. 2023. 51. 16. 8880-8890
Masanobu Nagano, Takumi Toda, Kurumi Makino, Hiroko Miki, Yoshiaki Sugizaki, Hideyuki Tomizawa, Atsunobu Isobayashi, Keitaro Yoshimoto. Discovery of a Highly Specific Anti-methotrexate (MTX) DNA Aptamer for Antibody-Independent MTX Detection. Analytical Chemistry. 2022. 94. 49. 17255-17262
Masanobu Nagano, Sosuke Nakano, Keitaro Yoshimoto. Evaluation of G-quartet-forming deoxyguanines in antiparallel G-quadruplexes using optical spectroscopy and deoxyguanine-to-deoxythymidine scanning. Analytical Biochemistry. 2022. 658. 114903-114903
The Chemical Society of Japan
, The Japan Society for Biomaterials
, The Society of Polymer Science, Japan
, The Japan Society for Analytical Chemistry
