Rchr
J-GLOBAL ID:201101064401515857
Update date: Apr. 05, 2025 Fujita Mitsugu
フジタ ミツグ | Fujita Mitsugu
Affiliation and department: Job title:
Associate Professor
Other affiliations (2): Research field (2):
Neurosurgery
, Immunology
Research keywords (2):
Tumor immunology
, Brain tumors
Research theme for competitive and other funds (37): - 2024 - 2027 病理組織学的空間解析を用いた食道癌個別化治療体系の開発
- 2024 - 2027 大腸癌の病理画像解析システムの開発と空間統計学的バイオマーカー検索
- 2024 - 2027 新規MRI解析と三次リンパ構造解析による頚動脈プラーク不安定機序の解明
- 2024 - 2027 難治性髄膜腫におけるがん免疫微小環境の解明
- 2024 - 2027 Elucidation of the Pathological Significance of CD276 Expression in M2 Macrophages in Primary Central Nervous System Lymphoma
- 2023 - 2026 GGCT阻害によるNotch制御機構の解明と膠芽腫幹細胞を標的する新規治療法の確立
- 2023 - 2026 Contribution of short-chain fatty acids and their receptor FFAR2/3 to lung fibrosis
- 2023 - 2026 Spatial Analysis of Rectal Cancer after Preoperative Chemoradiotherapy to Explore Predictors of Treatment Response
- 2023 - 2026 転移性脳腫瘍の制御を目的としたCAR-T細胞療法の開発に関する研究
- 2023 - 2025 Establishment of a platform for high-throughput CAR-T cell generation for gastric cancer
- 2022 - 2025 臨床的グリオーマ実験モデルを用いた放射線脳壊死関連マクロファージの機能解析
- 2022 - 2025 Development of new preoperative therapy for esophageal cancer based on the dynamics of tumor-infiltrating lymphocytes
- 2022 - 2025 腫瘍微小環境内 B 細胞を用いた転移性脳腫瘍に対する CAR-T 細胞療法の開発
- 2022 - 2025 Development of a novel treatment method using umbilical cord-derived mesenchymal stem cells for cerebral hemorrhage and investigation of their mechanism
- 2021 - 2024 バイオインフォマティクス的手法による放射線脳壊死関連M2マクロファージの機能解析
- 2021 - 2024 Development and application of an early detection method for postoperative recurrence of colorectal cancer using tears
- 2020 - 2023 Elucidation of the mechanism of maturation of tertiary lymph structure in gastric cancer tumor immune microenvironment and identification of the therapeutic antibodies
- 2020 - 2023 A study to elucidate the novel mechanism of Hedgehog pathway activation induced by GGCT-mediated metabolic reprograming
- 2020 - 2023 Regulation of metastatic brain tumors by targeting B7 molecules expressed on M2 macrophages
- 2019 - 2022 Elucidation of immune response to radiation brain necrosis using a clinical glioma experimental model
- 2019 - 2022 A novel cancer immunotherapy focused on organ specific immune memory generation
- 2018 - 2021 Significance of B7 family expressed on macrophages relevant to radiation necrosis of brain
- 2017 - 2020 Investigation of the immunotherapy targeting WT1 against grade 2/3 glioma and its promoting and inhibiting mechanism in the brain.
- 2016 - 2019 Identification of novel therapeutic targets to block crosstalk of Wnt/Shh/Hypoxia-pathway feedforward loops in glioblastoma stem cells
- 2016 - 2019 Elucidation of the mechanism of immune activation and identification of novel target molecules associated with allogeneic reactions
- 2015 - 2018 Elucidation of the M2 macrophage in brain metastases from lung cancer
- 2015 - 2018 Impact of M2 macrophages on glioma-relevant radiation necrosis of the brain
- 2014 - 2017 Analysis of pathophysiology of brain radiation necrosis and establishment of novel treatment strategy
- 2014 - 2017 Role of CCL28 for mucosal immunity
- 2014 - 2017 Combined WT1 vaccine immunotherapy and targeted chemotherapy against metastatic brain tumor
- 2013 - 2016 Characterization of Lgr5+ cells using a transposon-induced glioblastoma mouse model and identification of novel therapeutic targets
- 2014 - 2016 脳放射線壊死の病態解明と新規治療法の確立
- 2014 - 2016 粘膜免疫における CCL28 の役割の解明
- 2014 - 2016 転移性脳腫瘍におけるWT1ワクチン療法・分子標的治療併用新規集学的治療法の開発
- 2013 - 2015 トランスポゾン誘導型膠芽腫モデルを用いたLgr5+細胞の特性と新規治療標的の解明
- 2012 - 2014 COX-2 blockade immunologically suppresses brain metastasis of lung cancer
- 2012 - 2013 肺がん脳転移に対する非ステロイド系抗炎症薬による免疫学的予防法の確立
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Papers (182): -
Masasuke Ohno, Shunichiro Kuramitsu, Kimihiro Yamashita, Toru, Nagasaka, Shoichi Haimoto, Mitsugu Fujita. Tumor-Infiltrating B Cells and Tissue-Resident Memory T Cells as Prognostic Indicators in Brain Metastases Derived from Gastrointestinal Cancers. Cancers. 2024. 16. 22. 3765
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Kozue Nose, Keiko Taniguchi, Mitsugu Fujita, Chiami Moyama, Masaya Mori, Mizuki Ishita, Tatsushi Yoshida, Hiromi Ii, Toshiyuki Sakai, Susumu Nakata. γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels. Cancer Gene Therapy. 2024
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Toru Nagasaka, Kimihiro Yamashita, Mitsugu Fujita. Novel Methods for Analyzing Cellular Interactions in Deep Learning-Based Image Cytometry: Spatial Interaction Potential and Co-Localization Index. ArXiv. 2024. 2408. 16008
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Shota Nohira, Shunichiro Kuramitsu, Masasuke Ohno, Mitsugu Fujita, Kimihiro Yamashita, Toru Nagasaka, Shoichi Haimoto, Noriaki Sakakura, Hirokazu Matsushita, Ryuta Saito. Tertiary Lymphoid Structures in Brain Metastases of Lung Cancer: Prognostic Significance and Correlation With Clinical Outcomes. Anticancer research. 2024. 44. 8. 3615-3621
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Hiromasa Yoshioka, Takeshi Okuda, Mitsugu Fujita, Takayuki Nakao, Jun C. Takahashi. Survival Impact of Postoperative Whole-brain Radiotherapy and Systemic Chemotherapy After Surgical Resection of Brain Metastases. Anticancer Research. 2024. 44. 8. 3663-3667
more... MISC (13): -
森 昌也, 嶋田 絢子, 白木 里沙, 野瀬 梢, 谷口 恵香, 藤田 貢, 飯居 宏美, 中田 晋, 中田 晋. GGCTノックダウンはdesert hedgehog減少を介してマウス膠芽腫幹細胞の増殖を抑制する(Downregulation of desert hedgehog mediates suppression of mouse glioblastoma stem cell proliferation by GGCT knockdown). 日本癌学会総会記事. 2024. 83回. P-1080
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森 昌也, 嶋田 絢子, 谷口 恵香, 茂山 千愛美, 藤田 貢, 飯居 宏美, 中田 晋. マウス膠芽腫幹細胞におけるGGCTノックダウンによる細胞増殖抑制に対するDesert hedgehogの関与(Involvement of Desert hedgehog in the Anti-proliferative activity by GGCT knockdown in murine glioblastoma stem cells). 日本癌学会総会記事. 2023. 82回. 1001-1001
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野瀬 梢, 森 昌也, 茂山 千愛美, 飯居 宏美, 藤田 貢, 中田 晋. γ-glutamylcyclotransferase(GGCT)ノックダウンは膠芽腫幹細胞の増殖を抑制する。(γ-glutamylcyclotransferase knockdown inhibits proliferation of glioblastoma stem cells). 日本癌学会総会記事. 2023. 82回. 1000-1000
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茂山 千愛美, 藤田 貢, 東馬 智未, 安藤 翔太, 河野 雪那, 谷口 恵香, 飯居 宏美, 中田 晋. Stat5b阻害は発がんマウスモデル由来膠芽腫幹細胞にアポトーシスを誘導する. 日本薬学会年会要旨集. 2019. 139年会. 4. 141-141
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河野 雪那, 小島 直人, 茂山 千愛美, 東馬 智未, 藤田 貢, 安藤 翔太, 谷口 恵香, 飯居 宏美, 中田 晋. アセトゲニン誘導体JCI-20679は膠芽腫細胞に対するテモゾロミドの効果を増強する. 日本薬学会年会要旨集. 2019. 139年会. 4. 141-141
more... Books (1): - Brain Tumors - Current and Emerging Therapeutic Strategies, Immunotherapeutic Strategies for Brain Tumors
InTech 2011 ISBN:9789533075884
Lectures and oral presentations (170): -
病理AIイメージサイトメトリーと空間統計解析を活用した新たな定量形態学的手法の展望(Prospects for New Quantitative Morphological Methods Utilizing AI Image Cytometry and Spatial Statistical Analysis)
(日本病理学会会誌 2024)
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消化器がん脳転移における予後因子としての腫瘍浸潤B細胞とTRM
(日本癌治療学会学術集会抄録集 2024)
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膠芽腫幹細胞におけるγ-glutamylcyclotransferase(GGCT)ノックダウンによる増殖抑制効果(Anti-proliferation effect by γ-glutamylcyclotransferase(GGCT) knockdown in glioblastoma stem cells)
(日本癌学会総会記事 2024)
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GGCTノックダウンはdesert hedgehog減少を介してマウス膠芽腫幹細胞の増殖を抑制する(Downregulation of desert hedgehog mediates suppression of mouse glioblastoma stem cell proliferation by GGCT knockdown)
(日本癌学会総会記事 2024)
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消化器悪性腫瘍の脳転移における腫瘍浸潤B細胞と組織常在性メモリーT細胞の空間的分布と予後的価値(Prognostic Value of Tumor-Infiltrating B and T Cells in Brain Metastases from Gastrointestinal Cancers)
(日本癌学会総会記事 2024)
more... Education (2): - 2001 - 2005 Nagoya Universty Graduate School of Medicine (Ph.D.)
- 1991 - 1997 Nagoya University School of Medicine (M.D.)
Professional career (2): - Ph.D. (Nagoya University)
- M.D. (Nagoya University)
Work history (9): - 2021/04 - 現在 Kindai University Faculty of Medicine Center for Medical Education and Clinical Training Associate Professor
- 2012/04 - 2021/03 Kindai University Faculty of Medicine Department of Microbiology Associate Professor
- 2011/04 - 2012/03 Aichi Cancer Center Division of Cancer Immunology Section Head
- 2011/02 - 2011/03 Nagoya Daini Red Cross Hospital Department of Neurosurgery Senior Neurosurgeon
- 2009/11 - 2011/01 University of Pittsburgh School of Medicine Department of Neurological Surgery Assistant Professor
- 2008/11 - 2009/10 University of Pittsuburgh School of Medicine Department of Neurological Surgery Research Instructor
- 2006/01 - 2008/10 University of Pittsuburgh School of Medicine Department of Neurological Surgery Visiting Research Associate
- 1999/04 - 2001/03 Nagoya Daini Red Cross Hospital Department of Neurosurgery Neurosurgeon
- 1997/04 - 1999/03 Nagoya Daini Red Cross Hospital Resident
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Awards (10): - 2023/07 - 近畿大学医学部 2022年度 Good Support Teacher 賞
- 2023/07 - 近畿大学医学部 2022年度 Best teacher 賞
- 2022/08 - 近畿大学医学部 2021年度 Good Support Teacher 賞
- 2021/08 - 近畿大学医学部 2020年度 Good Teacher 賞
- 2012 - SGH 財団 優秀研究賞
- 2011 - 愛知県がん研究振興会 優秀研究賞
- 2010 - Society for Immunotherapy of Cancer Young Investigator Research Award
- 2009 - Walter L. Copeland Foundation Young Researcher Award
- 2008 - Walter L. Copeland Foundation Young Researcher Award
- 2005 - 上原記念生命科学財団 ポストドクトラルフェローシップ
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