Research keywords (5):
Cell Adhesion, migration, proliferation
, Glycosylation, Phosphorylation
, Integrin
, Extracellular Matrix (Laminin, Osteopontin etc)
, Cancer Invasion and Metastasis
Research theme for competitive and other funds (7):
2022 - 2025 リン酸化で再定義するオステオポンチンによる癌悪性化機構と創薬への応用
2017 - 2020 Molecular mechanism of chemoresistance induced by beta4 integrin and its overcoming
2014 - 2018 "Brain-type" glycosylation: A tag for diagnostic markers of central nervous system diseases
2013 - 2017 Molecular mechanism of alpha6beta4 integrin-dependent cancer cell survival
2009 - 2014 Change of oligosaccharides in cell adhesion, and its roles
2011 - 2013 Search for biomarkers of central nervous system diseases that show subtle morphological changes on MRI and CT.
2011 - 2012 Analysis of molecular mechanism of tumor progression induced by an alpha6beta4 integrin
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Papers (49):
Yoshinobu Kariya, Jianguo Gu, Yukiko Kariya. Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3-Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit. Biomolecules. 2023. 13. 12. 1752-1752
Yoshinobu Kariya, Yukiko Kariya. Osteopontin in Cancer: Mechanisms and Therapeutic Targets. International Journal of Translational Medicine. 2022. 2. 3. 419-447
Yoshinobu Kariya, Midori Oyama, Yukiko Kariya, Yasuhiro Hashimoto. Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility. Biomolecules. 2021. 11. 9. 1323-1323