Rchr
J-GLOBAL ID:201101078526247618   Update date: Feb. 01, 2024

ueda hiroshi

ウエダ ヒロシ | ueda hiroshi
Affiliation and department:
Job title: Principal Investigator
Other affiliations (1):
  • National Defense Medical Center  Graduate Institute of Pharmacology   Chair Professor
Research field  (6): Animals: biochemistry, physiology, behavioral science ,  Physiology ,  Neuroscience - general ,  Anesthesiology ,  Pharmaceuticals - health and biochemistry ,  Pharmacology
Research keywords  (16): neuropathic pain ,  fibromyalgia ,  Damage associated molecular patterns ,  Prothymosin α ,  Lysophosphatidic acid ,  ネクローシス ,  分泌 ,  情報伝達 ,  オピオイド ,  GTP結合蛋白質 ,  オピオイドレセプタ- ,  情報伝達機構 ,  ストレス性精神疾患 ,  アポト-シス ,  神経細胞死 ,  G蛋白質
Research theme for competitive and other funds  (66):
  • 2021 - 2025 雌性特異的疼痛メモリーを保持したT細胞サブセットによる脳-免疫相関機構
  • 2019 - 2021 Identification of key molecules in generalized chronic pain disease by use of eRNA-CAGE method toward DNA vaccine treatments
  • 2017 - 2021 LPA signaling molecules and basic diagnostic and therapeutic studies on chronic pain
  • 2017 - 2021 LPAシグナル制御薬の慢性疼痛診断・治療基盤研究
  • 2015 - 2019 Discovery of novel Nav1.7 inhibitors by using bioinformatics
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Papers (301):
  • Hiroshi Ueda. Non-Vesicular Release of Alarmin Prothymosin α Complex Associated with Annexin-2 Flop-Out. Cells. 2023. 12. 12. 1569-1569
  • Shiori Yamashita, Naoki Dozono, Shota Tobori, Kazuki Nagayasu, Shuji Kaneko, Hisashi Shirakawa, Hiroshi Ueda. Peripheral Beta-2 Adrenergic Receptors Mediate the Sympathetic Efferent Activation from Central Nervous System to Splenocytes in a Mouse Model of Fibromyalgia. International Journal of Molecular Sciences. 2023. 24. 4. 3465-3465
  • Hiroshi Ueda. Prothymosin α Plays Role as a Brain Guardian through Ecto-F1 ATPase-P2Y12 Complex and TLR4/MD2. Cells. 2023. 12. 3. 496-496
  • Hiroshi Ueda. Prothymosin α-derived hexapeptide prevents the brain damage and sequelae due to ischemia-hemorrhage. Peptides. 2023. 160. 170922-170922
  • Hiroyuki Neyama, Michiko Nishiyori, Yilong Cui, Yasuyoshi Watanabe, Hiroshi Ueda. Lysophosphatidic acid receptor type-1 mediates brain activation in micro-positron emission tomography analysis in a fibromyalgia-like mouse model. The European journal of neuroscience. 2022. 56. 3. 4224-4233
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MISC (215):
  • 浦田秀造, 浦田秀造, OMOTUYI Olaposi Idowu, 石川岳志, 水田賢志, 櫻井康晃, 櫻井康晃, 水谷龍明, 植田弘師, 田中義正, et al. Identification of novel chemical compounds which inhibited filovirus VP40-mediated virus-like particle (VLP) production. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)
  • Lysophosphatidic Acid Plays Key Roles in the Development and Maintenance of Chronic Pain Memory. 2020. 51. 1. 4-10
  • 植田 弘師, 根山 広行. 分子から迫る神経薬理学 神経疾患治療標的としてのリゾホスファチジン酸受容体機構. Clinical Neuroscience. 2019. 37. 12. 1422-1423
  • 浦田秀造, 石川岳志, 水田賢志, OLAPOSI Omotuyi, 水谷龍明, 植田弘師, 田中義正, 安田二朗, 安田二朗. フィロウイルスVP40による粒子形成を阻害する新規化合物の同定. 日本ウイルス学会学術集会プログラム・予稿集(Web). 2019. 67th
  • LPA signaling in fibromyalgia and neuropathic pain. 2018. 76. 11. 1902-1906
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Patents (14):
Books (4):
  • はじめての痛み学
    おうふう 2011 ISBN:4273036703
  • "痛みのしくみ"とその歪み : 痛みの慢性化理解のための10項目
    日本臓器製薬 2011
  • わかる痛み学
    ブレーン出版 2009 ISBN:4892429414
  • やさしい痛み学
    ブレーン出版 2007 ISBN:4892428965
Lectures and oral presentations  (230):
  • Centralized Painとしての線維筋痛症動物モデル 病態生理学と治療薬理学
    (日本線維筋痛症学会第10回学術集会 2018)
  • 脳虚血ストレスから脳を守るDAMPs/Alarminsプロサイモシンα
    (第40回日本生物学的精神医学会・第61回日本神経化学会大会合同年会 2018)
  • Prothymosin α plays multifunctional robustness roles against fatal stresses in neurons.
    (京都大学iPS細胞研究所 2018)
  • 脳虚血時の神経保護機能を有するDAMPsプロサイモシンα
    (第41回日本神経科学大会 2018)
  • 【Invited Lectures】Lysophosphatidic acid signaling is involved in the development and maintenance of neuropathic pain and fibromyalgia.
    (the 18th World Congress of Basic and Clinical Pharmacology(WCP2018) 2018)
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Education (3):
  • 1978 - 1981 Kyoto University
  • 1976 - 1978 Kyoto University
  • 1972 - 1976 Kyoto University Department of Pharmacy
Professional career (1):
  • Philosophy of Doctor (Pharmaceutical Sciences) (Kyoto University)
Work history (7):
  • 2019/06 - 現在 Nagasaki University Emeritus Professor
  • 2019/04 - Kyoto University Graduate School of Pharmaceutical Sciences Department of Molecular Pharmacology Researcher
  • 2002/04 - 2019/03 Nagasaki University Graduate School of Professor & Chairman,
  • 1996/04 - 2019/03 Nagasaki University Pharmaceutical Sciences Professor & Chairman
  • 1991/09 - 1996/03 Yokohama City University School of Medicine Department of Pharmacology Associate Professor,
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Committee career (10):
  • 2009 - 現在 日本線維筋痛症学会 理事 2012年より副理事長
  • 1997 - 現在 日本生化学会 評議員
  • 1985 - 現在 日本薬理学会 評議員
  • 2012/04 - 2017/03 文科省(AMED)創薬等ライフサイエンス研究支援基盤事業 課題管理者
  • 2010 - 2016 International Association for Study of Pain Councilor
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Awards (4):
  • 2022 - Peptides Gayle A.Olson & Richard D Olson Prize 2020 Sasaki K, Halder SK, Matsunaga H, Ueda H. Beneficial actions of prothymosin alpha-mimetic hexapeptide on central post-stroke pain, reduced social activity, learning-deficit and depression following cerebral ischemia in mice. Peptides 126: 170265, 2020
  • 2019/03 - The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award 2019
  • 1989/03 - The Society for Japanese Pharmaceutical Sciences Prize of Encouragement from the Society for Japanese Pharmaceutical Sciences
  • 1985/04 - The Society for Japanese Pharmacology Prize of Encouragement for Young Scientists from the Society for Japanese Pharmacology
Association Membership(s) (10):
International Association for the Study of Pain ,  Society for Neuroscience ,  International Narcotics Research Conference ,  THE JAPAN NEUROSCIENCE SOCIETY ,  THE JAPANESE SOCIETY FOR NEUROCHEMISTRY ,  Japanese College of Fibromyalgia Investigation ,  JAPANESE ASSOCIATION FOR THE STUDY OF PAIN ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN
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