Research field (2)：
Neuroanatomy and physiology
, Pathobiochemistry
Research theme for competitive and other funds (6)：
2022 - 2025 多機能化一本鎖抗体によるアミロイドβ凝集体細胞内スワイプ療法の開発
2020 - 2023 異常凝集体に対する体外診断法開発によるアルツハイマー病の早期診断と病態解明
2017 - 2020 Propagation of Alzheimer's disease neuronal cell death by intracellular formation and secretion of abnormal aggregates
2014 - 2017 Elucidation of a neurodegenerative mechanism induced by a new Alzheimer's disease drug target and its inhibition
2011 - 2014 A study on the molecular mechanisms of neurodegeneration induced by high-mass amyloid-beta assembly, amylospheroids (ASPD)
2004 - 2005 Elucidation of the neurodegenerative mechanism induced by amylospheroid
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Papers (29)：
Tomoya Sasahara, Minako Hoshi. High-throughput screening for agonists of ROS production in live human vascular endothelial cells. STAR protocols. 2022. 3. 1. 101053-101053
Tomoya Sasahara, Kaori Satomura, Mari Tada, Akiyoshi Kakita, Minako Hoshi. Alzheimer's Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells. iScience. 2021. 24. 9. 102936-102936
Minako Hoshi. Multi-angle development of therapeutic methods for Alzheimer's disease. (cover). British journal of pharmacology. 2021. 178. 4. 770-783
Koshi Murata, Tomoki Kinoshita, Tatsuya Ishikawa, Kazuki Kuroda, Minako Hoshi, Yugo Fukazawa. Region- and neuronal-subtype-specific expression of Na,K-ATPase alpha and beta subunit isoforms in the mouse brain. The Journal of comparative neurology. 2020. 528. 16. 2654-2678
Naoko Iwaya, Natsuko Goda, Mizuki Matsuzaki, Akihiro Narita, Yoshiki Shigemitsu, Takeshi Tenno, Yoshito Abe, Minako Hoshi, Hidekazu Hiroaki. Principal component analysis of data from NMR titration experiment of uniformly 15N labeled amyloid beta (1-42) peptide with osmolytes and phenolic compounds. Archives of biochemistry and biophysics. 2020. 690. 108446-108446
Enlightening Protein Assembly Pathways Leading to Alzheimer Disease
(IBRI Mini-Workshop on amyloid-beta protein oligomer amyloid-beta protein assembly “Deciphering the mystery of amyloid-beta protein assembly.”, organized by Professors Hiroaki and Hoshi 2011)
A new toxic target for a high-mass amyloid β-protein assembly with a unique toxic structure
(“International conference on Alzheimer’s disease: Return to the Basics”, organized by Professors Iwata and Hoshi 2011)
High-mass amyloid beta-protein assembly with a unique toxic surface from Alzheimer's disease brains
(“Prion and Virus Infections”, organized by Drs. Nagayama, Sokabe and Kataoka 2009)
