Research theme for competitive and other funds (11):
2022 - 2025 Pathophysiological mechanism for mitochondrial Na/Ca exchanger and its therapeutic application
2021 - 2024 Molecular Mechanisms of Potassium Channel Facilitation by Blockers and its Impact on Arrhythmias
2015 - 2018 Regulation of the m2 muscarinic ACh receptor-mediated signaling by RGS proteins
2015 - 2017 TASKチャネルを標的とする低酸素応答機構に関する研究
2010 - 2016 Research and development of a software platform for integrative multi-level systems biology
2012 - 2015 Elucidation of the Molecular Mechanism underlying the Sphingolipid-Mediated Regulation of Potassium Channel Function
2010 - 2011 A New Approach to Searching for the Bioactive Molecules Regulating Potassium Channel
2008 - 2010 薬物によるカリウムチャネル機能制御の構造活性相関の解明
2008 - 2010 Studies on the structure-activity relationship on pharmacological modulations of potassium channels
2008 - 2009 A study on the mechanism for the dynamic position control of neuronal inward rectifier potassium channels.
2005 - 2009 Physiological regulation of G protein signaling by RGS proteins
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Papers (31):
Kevin R DeMarco, Pei-Chi Yang, Vikrant Singh, Kazuharu Furutani, John R D Dawson, Mao-Tsuen Jeng, James Fettinger, Slava Bekker, Van A Ngo, Sergei Y Noskov, et al. Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline. Journal of molecular and cellular cardiology. 2021
Yosuke Funato, Kazuharu Furutani, Yoshihisa Kurachi, Hiroaki Miki. CrossTalk proposal: CNNM proteins are Na+ /Mg2+ exchangers playing a central role in transepithelial Mg2+ (re)absorption. The Journal of physiology. 2018. 596. 5. 743-746
KUROKAWA Junko, ASHIHARA Takashi, KANDA Yasunari, NAGAMORI Shushi, FURUTANI Kazuharu. Non-clinical cardiovascular toxicology using in silico approaches. Annual Meeting of the Japanese Society of Toxicology. 2016. 43. S21-2
Yuko Yamakawa, Kazuharu Furutani, Atsushi Inanobe, Yoshihisa Kurachi. in silico analysis of hERG channel facilitators. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 156P-156P
Daisuke Kamimura, Tomohito Ohtani, Yasushi Sakata, Toshiaki Mano, Yasuharu Takeda, Shunsuke Tamaki, Yosuke Omori, Yasumasa Tsukamoto, Kazuharu Furutani, Yutaka Komiyama, et al. Inhibition of Ca2+Entry Mode of Na+/Ca2+Exchanger Improves Survival Rate of Rat Model for Heart Failure with Preserved Ejection Fraction. CIRCULATION. 2011. 124. 21