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Rchr

J-GLOBAL ID：201201019701928047 Update date: Feb. 04, 2025

Kobayashi Hotaka

コバヤシホタカ | Kobayashi Hotaka

Affiliation and department：
Job title： Associate Professor
Other affiliations (2)：

The University of Tokyo Institute for Quantitative Biosciences (IQB) Visiting Associate Professor
Japan Science and Technology Agency PRESTO Researcher

Homepage URL (1)： https://sites.google.com/view/h-kobayashi-lab

Research field (3)： Neuroscience - general , Molecular biology , Cell biology

Research keywords (17)： Organelle , Vesicular transport , Rab , Arf , Neurite outgrowth , Comprehensive Brain Science Network , Non-coding RNA , Small RNA , microRNA (miRNA) , Argonaute (AGO) , RNA-induced silencing complex (RISC) , RNA silencing , Iruka , Autophagy , mRNA , Translation , In-cell single-molecule imaging

Research theme for competitive and other funds (8)：

2023 - 2025 高時空間解像度イメージングという視点から翻訳の典型的・非典型的な制御機構に迫る
2021 - 2024 RISCの機能発現を1分子mRNAレベルで「見る・操る」
2017 - 2019 Dissecting the mechanism for autophagic degradation of empty Argonaute
2017 - 2018 IrukaによるmicroRNA非結合型Argonauteの選択的ユビキチン化機構の解析
2017 - 2018 国立大学改革強化推進補助金スタートアップ支援経費

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Papers (15)：

Hotaka Kobayashi, Robert H. Singer. Single-molecule imaging of microRNA-mediated gene silencing in cells. Nature Communications. 2022. 13. 1
Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021. 17. 1. 1-382
Hotaka Kobayashi, Yukihide Tomari. Identification of an AGO (Argonaute) protein as a prey of TER94/VCP. Autophagy. 2020. 16. 1. 190-192
Hotaka Kobayashi, Keisuke Shoji, Kaori Kiyokawa, Lumi Negishi, Yukihide Tomari. VCP Machinery Mediates Autophagic Degradation of Empty Argonaute. Cell Reports. 2019. 28. 5. 1144-1153
Hotaka Kobayashi, Keisuke Shoji, Kaori Kiyokawa, Lumi Negishi, Yukihide Tomari. Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State. Molecular Cell. 2019. 73. 1. 119-129

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MISC (1)：

H. Kobayashi, M. Fukuda. Rab cluster as a novel mechanism that concentrates multiple Rab-signalings. MOLECULAR BIOLOGY OF THE CELL. 2013. 24

Books (8)：

microRNAによる遺伝子発現抑制と相分離
医学のあゆみ「生物学的相分離と計測技術」(医歯薬出版) 2025
microRNAの発見とその歩み
化学 2024年12月号(化学同人) 2024
miRNA経路の全体像
RNAの科学 : 時代を拓く生体分子(朝倉書店) 2024 ISBN:9784254171860
Detecting mRNAs and translated peptides with IF-FISH
2024
microRNAによる遺伝子サイレンシングの1分子解析
生物物理(日本生物物理学会) 2023

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Lectures and oral presentations (41)：

Imaging translational regulation at single-cell and single-mRNA resolution
(Karolinska Institutet Guest Seminar (Invited Talk) 2024)
Single-molecule imaging of translational regulation in cells
(International Symposium on Multifaceted Protein Dynamics (Talk) 2024)
細胞内1分子イメージングを武器にmicroRNAの謎に迫る
(2024年度徳島大学先端酵素学研究所シンポジウム(招待講演) 2024)
When and where do microRNAs work in cells?
(2024)
Imaging how mRNA vaccines work in cells
(The 2nd UTOPIA Symposium (Invited Talk) 2024)

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Education (3)：

2011 - 2014 Tohoku University Graduate School of Life Sciences Department of Developmental Biology and Neurosciences
2009 - 2011 Tohoku University Graduate School of Life Sciences Department of Developmental Biology and Neurosciences
2005 - 2009 Tohoku University Faculty of Science Department of Biology

Professional career (1)：

Ph.D. (Tohoku University)

Work history (12)：

2023/10 - 現在 The University of Tokyo Institute for Quantitative Biosciences Visiting Associate Professor
2023/10 - 現在 Tokushima University Institute of Advanced Medical Sciences Associate Professor
2021/04 - 2025/03 Japan Science and Technology Agency (JST) PRESTO Researcher
2021/10 - 2023/09 The University of Tokyo Institute for Quantitative Biosciences Lecturer
2020/07 - 2023/03 Ministry of Education, Culture, Sports, Science and Technology (MEXT) Leading Initiative for Excellent Young Researchers Candidate

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Awards (23)：

2024/07 - 日本細胞生物学会若手最優秀発表賞
2024/04 - 文部科学大臣表彰若手科学者賞
2023/07 - PSSJ Young Scientist Award for Excellence
2023/04 - PSSJ Young Scientist Award
2022/09 - International Union for Pure and Applied Biophysics, IUPAB award

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Association Membership(s) (7)：

日本細胞生物学会 , Protein Science Society of Japan , The Biophysical Society of Japan , The RNA Society of Japan , The Japanese Biochemical Society , The Molecular Biology Society of Japan , The American Society for Cell Biology

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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