Rchr
J-GLOBAL ID:201201028969040510
Update date: Jan. 08, 2025 SAKAGUCHI Masanori
Sakaguchi Masanori | SAKAGUCHI Masanori
Affiliation and department: Job title:
Associate Professor
Homepage URL (1): https://sakaguchi-lab.org/ Research field (1):
Cognitive neuroscience
Research keywords (7):
新生ニューロン
, 記憶
, 睡眠
, 海馬
, 生体脳イメージング
, 光遺伝学
, 深層学習
Research theme for competitive and other funds (25): - 2022 - 2029 Deciphering the mysteries of sleep:creating a global network of sleep neurobiologists
- 2024 - 2027 睡眠中の音刺激によるPTSDの新規治療法の開発
- 2024 - 2027 睡眠中の音刺激による環世界マニピレーション
- 2023 - 2026 レム睡眠中に恐怖記憶が再想起する意義の解明
- 2022 - 2025 Molecular Research and Treatment of Fear Memory in PTSD
- 2020 - 2025 睡眠と冬眠:2つの「眠り」の解明と操作が拓く新世代医療の展開
- 2021 - 2024 Study of the principles of consciousness
- 2021 - 2024 Mechanisms of consciousness based on synchronous activity in the brain
- 2022 - 2023 Elucidation of pattern sepration mechanism based on new and old neruon interaction
- 2021 - 2023 Mechanisms of adult-born neurons for memory cosolidation in sleep
- 2021 - 2023 Function of synapse pruning in the regenerating memory circuit.
- 2020 - 2023 睡眠中の記憶固定化におけるシナプス可塑性の意義の解明
- 2021 - 2022 Elucidation of the mechanism of memory fixation during sleep
- 2019 - 2022 レム睡眠中の記憶固定化におけるSRFの役割
- 2021 - Functional disruption of plastic neural circuits behind anxiety disorders
- 2016 - 2021 Development and application of optical technology for spatiotemporal control of biological functions
- 2016 - 2020 Memory trace consolidated by new-born neurons
- 2015 - 2018 Integration of the adult-born neurons into memory circuits during sleep
- 2017 - 2018 Metabolome for sleep-dependent memory consolidation by adult-born neurons
- 2014 - 2016 睡眠中の新生ニュー ロンの活性化が記憶に及ぼす機能
- 2013 - 2015 心的外傷後ストレス障害(PTSD)における記憶情報処理の病態生理
- 2015 - GSK財団: 研究助成金
- 2012 - 2014 Memory transfer across neural networks
- 2011 - Uehara Memorial Foundation
- 2006 - 2007 成体中枢神経幹細胞における糖鎖分子の機能解析
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Papers (53): -
Yuteng Wang, Pablo Vergara, Satoshi Hasegawa, Naoki Tomita, Yoan Cherasse, Toshie Naoi, Takeshi Sakurai, Yuki Sugaya, Masanobu Kano, Masanori Sakaguchi. T-scope V4: miniaturized microscope for optogenetic tagging in freely behaving animals. 2024
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Kaizhen Li, Konstantinos Koukoutselos, Masanori Sakaguchi, Stéphane Ciocchi. Distinct ventral hippocampal inhibitory microcircuits regulating anxiety and fear behaviors. Nature Communications. 2024
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Mitsuaki Kashiwagi, Goichi Beck, Mika Kanuka, Yoshifumi Arai, Kaeko Tanaka, Chika Tatsuzawa, Yumiko Koga, Yuki C. Saito, Marina Takagi, Yo Oishi, et al. A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson’s disease. Cell. 2024
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Chinatsu Kawakami, Toshie Naoi, Masanori Sakaguchi. Spaced conditioned stimulus presentation facilitates the extinction of strong fear memory in mice. Biochemical and Biophysical Research Communications. 2024. 150071-150071
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He Z, Vergara P, Tezuka T, Sakaguchi M. Real-Time Detection of Motifs from semi-Synthetic Calcium Imaging Data with Various Noise Types. 2024
more... MISC (14): -
菅谷 佑樹, 坂口 昌徳. 成体海馬の新生ニューロンが睡眠中に記憶を固定化する. BRAIN and NERVE: 神経研究の進歩. 2021. 73. 7. 0813-0817
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石橋 哲, 坂口 昌徳, 山根 淳一, 金村 米博, 中村 雅也, 澤本 和延, 戸山 芳昭, 岡野 栄之, 水澤 英洋. 局所脳虚血モデルに対するガレクチン-1遺伝子導入ヒト神経幹細胞移植効果の検討. 臨床神経学. 2012. 52. 12. 1404-1404
- 廣田ゆき, MEUNIER Alice, 黄詩惠, 下澤東吾, 山田理, 木田泰之, 井上雅史, 伊東翼, 加藤寛子, 坂口昌徳, et al. 非筋細胞ミオシンIIによるマウス上衣細胞繊毛の平面極性制御. Nagoya Med J. 2011. 51. 4. 219
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Yoichi Imaizumi, Masanori Sakaguchi, Tsuyoshi Morishita, Mamoru Ito, Francoise Poirier, Kazunobu Sawamoto, Hideyuki Okano. Galectin-1 is expressed in early type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus. NEUROSCIENCE RESEARCH. 2010. 68. E365-E365
- Makiko Ikeda, Yuki Hirota, Masanori Sakaguchi, Osamu Yamada, Yasuyuki Kida, Tashihiko Ogura, Takanobu Otsuka, Hideyuki Okano, Kazunobu Sawamoto. Role of Diversin as a possible switch of distinct Wnt pathways regulating multiple steps of adult neurogenesis. NEUROSCIENCE RESEARCH. 2009. 65. S54-S54
more... Patents (6): -
判定装置、光照射装置、及びプログラム
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小型撮像装置
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Agent for inhibiting proliferation of neural stem cells.
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Methods for enhancing survival and/or proliferation of neural stem cells and neurite extension enhancers therefore pharmaceutical compositions containing neural stem cells assay methods and screening methods.
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Method of promoting subsistence and/or proliferation of neural stem cell and promoting extension of neurite, promoter therefor, pharmaceutical composition containing neural stem cell, method of assay and method of screening
more... Books (11): - 睡眠学第2版
朝倉書店 2019
- トラウマ記憶を弱めるには ? マウスの記憶・睡眠研究から考えるPTSDケア
AdademistJournal 2017
- トラウマ直後の環境条件の記憶汎化における重要性-心的外傷後ストレス障害(PTSD)治療における意義
医歯薬出版(株) 2016
- 脳内で新生するニューロンと、中枢神経再生への応用
クバプロ 2016 ISBN:9784878051456
- Recombinant sugar binding proteins and their functional analysis: Galectin-1
JCGGDB 2014
more... Lectures and oral presentations (58): -
Hippocampal Adult-Born Neurons for Memory Consolidation during REM Sleep
(U of T Brain and Bee seminar 2022)
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CaliAli (Calcium imaging inter-session alignment): neuronal tracing utilizing vasculature in calcium imaging
(Frankland lab seminar 2022)
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Fully automatic sleep stage-specific intervention using single EEG in mice
(Frankland lab seminar 2022)
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Transient recruitment of adult-born neurons for fear memory consolidation in REM sleep
(2022)
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CaliAli (Calcium imaging inter-session alignment): neuronal tracing utilizing vasculature in calcium imaging
(2022)
more... Education (2): - 2001 - 2005 Tsukuba University Conprehensive Human Sciences Medicine Doctural Course
- 1995 - 2001 Tsukuba University School of Medicine Department of Medicine
Professional career (1): Work history (12): - 2022/04 - 現在 University of Tsukuba Faculty of Medicine Assc Prof (Tenure)
- 2021/10 - 現在 National Center of Neurology and Psychiatry
- 2018/10 - 現在 Tsukuba University International Institute for Integrative Sleep Medicine Associate Professor, PI
- 2013/04 - 2018/09 Tsukuba University International Institute for Integrative Sleep Medicine Associate Professor, co-PI
- 2013/02 - 2013/03 Univ. Tsukuba WPI-IIIS Researcher
- 2012/08 - 2013/03 国立研究開発法人 国立精神・神経医療研究センター 成人精神保健研究部・中島聡美研究室 研究生
- 2011/04 - 2013/01 RIKEN Special Postdoctoral Fellow (SPD)
- 2010/10 - 2011/03 RIKEN Brain Science Institute Researcher
- 2009/04 - 2010/09 Japan Society for the Promotion of Science Overseas Research Fellowships
- 2007/04 - 2009/03 SickKids Researcher
- 2005/04 - 2007/03 Keio University assistant
- 2001/04 - 2005/03 Keio University School of Medicine Physiological Laboratory Research Student
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Awards (9): - 2022/10 - 筑波大学 優秀教員表彰
- 2021/01 - 2021 Inscopix Tech Award SFN Global connectome
- 2016 - Society for Neuroscience Neuroscience?2016 HotTopic The role of adult born neurons in memory consolidation during sleep-wake cycles
- 2015 - The Adult Neurogenesis Conference 優秀発表賞
- 2014 - Homeodynamics in Clocks, Sleep and Metabolism Tokyo Translational Therapeutics Meeting 優秀発表賞 The role of adult born neurons during sleep
- 2008 - The Hospital for Sick Children 優秀発表賞
- 2008 - The Hospital for Sick Children, Travel Award for conference 優秀発表賞
- 2007 - The Hospital for Sick Children Research Institute Restracomp Award
- 2004 - Keystone Symposia Keystone Symposia Scholarship Award
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