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J-GLOBAL ID:201201054235118536   Update date: Jan. 13, 2025

Uchida Shusaku

Uchida Shusaku
Affiliation and department:
Research field  (5): Experimental psychology ,  Sports science ,  Nutrition and health science ,  Neuroscience - general ,  Psychiatry
Research keywords  (14): 動物モデル ,  神経回路 ,  栄養学 ,  層別化 ,  個体差 ,  記憶・学習 ,  気分障害 ,  ストレス ,  うつ病 ,  遺伝子発現制御 ,  エピジェネティクス ,  神経可塑性 ,  ストレス脆弱性 ,  神経新生
Research theme for competitive and other funds  (18):
  • 2022 - 2025 心の健康増進をめざしたストレス感受性の生物学的基盤の解明
  • 2021 - 2023 運動によるストレスレジリエンス獲得の分子・神経メカニズム解明
  • 2021 - 2023 細胞内分子複合体の多様性から紐解くストレス感受性の個体差構築のメカニズム
  • 2019 - 2021 ストレス感受性の個性創発の分子神経基盤解析
  • 2019 - 2021 ストレス感受性制御を司る脳内メカニズムの構成的理解
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Papers (58):
  • Yoshikazu Morishita, Ileana Fuentes, Sofia Gonzalez-Salinas, John Favate, Jennifer Mejaes, Ko Zushida, Akinori Nishi, Charles Hevi, Noriko Goldsmith, Steve Buyske, et al. Dopamine release and dopamine-related gene expression in the amygdala are modulated by the gastrin-releasing peptide in opposite directions during stress-enhanced fear learning and extinction. Molecular psychiatry. 2024
  • Ayako Kawatake-Kuno, Haiyan Li, Hiromichi Inaba, Momoka Hikosaka, Erina Ishimori, Takatoshi Ueki, Yury Garkun, Hirofumi Morishita, Shuh Narumiya, Naoya Oishi, et al. Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons. Neuron. 2024
  • Haiyan Li, Ayako Kawatake-Kuno, Hiromichi Inaba, Yuka Miyake, Yukihiro Itoh, Takatoshi Ueki, Naoya Oishi, Toshiya Murai, Takayoshi Suzuki, Shusaku Uchida. Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice. Neuron. 2024
  • Yukihiro Itoh, Peng Zhan, Toshifumi Tojo, Pattaporn Jaikhan, Yosuke Ota, Miki Suzuki, Ying Li, Zi Hui, Yukiko Moriyama, Yuri Takada, et al. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. Journal of medicinal chemistry. 2023
  • Hiromichi Inaba, Haiyan Li, Ayako Kawatake-Kuno, Ken-ichi Dewa, Jun Nagai, Naoya Oishi, Toshiya Murai, Shusaku Uchida. GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency. Science Advances. 2023. 9. 14
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MISC (93):
Patents (2):
  • 50歳未満発症うつ病の罹患の有無を予測する方法
  • ヒストン脱アセチル化酵素阻害剤
Lectures and oral presentations  (13):
  • Molecular and Neural mechanisms of psychosocial stress-induced behavioral heterogeneity
    (Universität Hamburg-Kyoto University Join Symposium 2023)
  • ストレス適応の個体差構築の分子神経基盤
    (2022)
  • Constructive understanding of the mechanisms underlying psychosocial stress-induced behavioral heterogeneity
    (2nd International Symposium of “Multi-scale Brain” 2022)
  • Epigenetic mechanisms driving synaptic plasticity and affective states under stressful situation
    (第44回日本神経科学会 2021)
  • ストレス感受性制御の脳内分子基盤
    (第51回日本神経精神薬理学会・第43回日本生物学的精神医学会年会 2021)
more...
Work history (5):
  • 2023/11 - 現在 Nagoya City University
  • 2018/04 - 2023/10 Kyoto University Graduate School of Medicine Medical Innovation Center
  • 2013/12 - 2018/03 Yamaguchi University Hospital
  • 2011/02 - 2013/11 日本学術振興会海外特別研究員(ラトガース・ニュージャージー州立大学) ポスドク
  • 2008 - 2011 山口大学 医学(系)研究科(研究院) 助教
Association Membership(s) (6):
北米神経科学会 ,  JAPANESE SOCIETY OF BIOLOGICAL PSYCHIATRY ,  THE JAPANESE SOCIETY FOR NEUROCHEMISTRY ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  日本神経科学会 ,  日本神経精神薬理学会
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