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J-GLOBAL ID：201201073454576315 Update date: Mar. 06, 2025

Fukuda Tomohiko

フクダトモヒコ | Fukuda Tomohiko

Affiliation and department：
Job title：准教授
Homepage URL (1)： https://nrid.nii.ac.jp/nrid/1000040433510/

Research field (4)： Pharmacology , Pharmaceuticals - health and biochemistry , Clinical pharmacy , Functional biochemistry

Research keywords (14)：統合失調症 , Fut8 , ミクログリア , 神経炎症 , 糖鎖 , 癌 , 薬学 , 酵素 , 蛋白質 , 生体分子 , GnT-III , インテグリン , 糖転移酵素 , GnT-V

Research theme for competitive and other funds (18)：

2024 - 2027 Preventive effect of L-fucose administration on the onset of depression and its mechanism
2023 - 2027 Analysis of underlying molecular mechanism for the regulation of chemoresistance by GnT-III
2023 - 2027 糖転移酵素GnT-IIIによるがんの薬剤耐性の制御とその分子機序の解明
2022 - 2025 Elucidation of molecular mechanism for IgG levels regulated by L-fucose
2021 - 2024 Elucidation of neuroinflammation and brain function control mechanism by alpha1,6 fucose

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Papers (70)：

Zixuan Cai, Tomoya Isaji, Caixia Liang, Tomohiko Fukuda, Dongmei Zhang, Jianguo Gu. Fucosyltransferase 4 upregulates P-gp expression for chemoresistance via NF-κB signaling pathway. Biochimica et biophysica acta. General subjects. 2025. 1869. 2. 130753-130753
Dan Wang, Tomohiko Fukuda, Tiangui Wu, Xing Xu, Tomoya Isaji, Jianguo Gu. Exogenous L-fucose attenuates depression induced by chronic unpredictable stress: Implicating core fucosylation has an antidepressant potential. The Journal of biological chemistry. 2025. 301. 3. 108230-108230
Zhiwei Zhang, Tomoya Isaji, Yoshiyuki Oyama, Jianwei Liu, Zhiwei Xu, Yuhan Sun, Tomohiko Fukuda, Haojie Lu, Jianguo Gu. O-GlcNAcylation of Focal Adhesion Kinase Regulates Cell Adhesion, Migration, and Proliferation via the FAK/AKT Pathway. Biomolecules. 2024. 14. 12
Tiangui Wu, Yuhan Sun, Dan Wang, Tomoya Isaji, Tomohiko Fukuda, Chiharu Suzuki, Hisatoshi Hanamatsu, Takashi Nishikaze, Hiroki Tsumoto, Yuri Miura, et al. The acetylglucosaminyltransferase GnT-III regulates erythroid differentiation through ERK/MAPK signaling. The Journal of biological chemistry. 2024. 300. 12. 108010-108010
Yuhan Sun, Xing Xu, Tiangui Wu, Tomohiko Fukuda, Tomoya Isaji, Sayaka Morii, Miyako Nakano, Jianguo Gu. Core fucosylation within the Fc-FcγR degradation pathway promotes enhanced IgG levels via exogenous L-fucose. The Journal of biological chemistry. 2024. 300. 8. 107558-107558

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