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J-GLOBAL ID：201201090744390101 Update date: Mar. 23, 2025

Kioi Mitomu

キオイミトム | Kioi Mitomu

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/30545059.ja.html

Research field (4)： Laboratory animal science , Tumor diagnostics and therapeutics , Tumor biology , Surgical dentistry

Research keywords (6)：老化 , hypoxia , targeted therapy , angiogenesis , tumor microenvironment , cancer biology

Research theme for competitive and other funds (29)：

2023 - 2026 再発・転移口腔癌オルガノイドを用いた治療抵抗性克服を目指す治療戦略
2023 - 2026 口腔癌に対する動注化学放射線療法とハイパーサーミアの併用治療に関する実験的研究
2022 - 2025 The role of M2 macrophage associated with treatment resistance in oral cancer and establishment of therapeutic strategy
2022 - 2025 The role of tumor microenvironment associated with lymph node metastasis in tongue cancer
2022 - 2025 免疫チェックポイント阻害薬耐性克服を目指した新規動注免疫療法の開発

2020 - 2023 Establishment of novel treatment strategy for oral cancer using patient-derived in vitro model with heterogeneous characters

2019 - 2022 口腔癌頸部リンパ節転移に対するICGラクトソームを用いたセラノスティクス

2018 - 2021 温熱療法とIL-1R阻害薬の臨床応用に向けた併用療法の開発

2018 - 2021 進行口腔癌に対する動注養子免疫療法と免疫チェックポイント阻害剤併用療法の開発

2017 - 2020 Potency of recruited CD206+cells into recurrent oral cancer as a biomarker and treatment target

2017 - 2020 Development of hyperthermia for the treatment of oral cancer using magnetite anti-EGFR antibody.

2017 - 2020 腫瘍治療電場(TTF)を用いた口腔癌に対する低侵襲治療法の開発

2015 - 2019 Efficacy of proton beam therapy for advanced oral cancer with cervical lymph node metastasis

2014 - 2018 Development of combination theray with hyperthermia and Interleukin-1 inhibitor.

2014 - 2018 Development of oral cancer treatment by hyperthermia generated with contrast agent Resovist and Cetuximab

2014 - 2018 The role of bone marrow-derived CD11b positive cells in recurrence of oral cancer

2014 - 2016 Epigenetic analysis of oral cancer stem cells involved in cancer recurrence

2011 - 2013 The role of macrophage polarization in recurrence of oral cancer

2011 - 2013 Overexpression of the atypical protein kinase C rambda/iota in oral squamous cell carcinoma is associated with degrees of malignancy

2013 - 転移に関わる癌幹細胞のエピゲノム解析と標的因子の探索

2012 - 歯周病と発癌性に対する疫学的調査とその分子メカニズムの解析

2012 - 口腔がん治療後に起こる微小環境変化に伴う腫瘍血管の再形成メカニズムの解明と新規標的薬物薬の開発

2012 - 頭頸部癌幹細胞と微小環境を標的とする低侵襲性新規治療法の開発

2011 - 微小環境ニッチに潜む癌幹細胞のエピゲノム変化と骨髄細胞のリクルートメント

2011 - 癌微小環境変化における骨髄ミエロイド細胞の役割

2011 - 口腔がん治療後に起こる微小環境変化に伴う腫瘍血管の再形成メカニズムの解明と新規標的薬物薬の開発

2011 - がん再発に関わるCD11b+骨髄単球細胞の腫瘍血管再形成における役割

2010 - 癌の転移に関わる骨髄細胞とpremetastatic nicheの解析

2010 - 口腔がん治療後に起こる微小環境変化に伴う腫瘍血管の再形成メカニズムの解明と新規標的薬物薬の開発

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Papers (81)：

Hitoshi Isono, Shintaro Nakajima, Satoshi Watanabe, Aya K. Takeda, Haruka Yoshii, Ami Shimoda, Hisao Yagishita, Kenji Mitsudo, Mitomu Kioi. Involvement of Oral Microbiome in the Development of Oral Malignancy. Cancers. 2025. 17. 4. 632-632
大屋貴志, 陳雪霏, 石川聡一郎, 竹田敦, 大橋伸英, 林雄一郎, 小栗千里, 小泉敏之, 來生知, 光藤健司. 舌癌に対する逆行性超選択的動注化学放射線療法119例における栄養摂取状況の分析. 日本口腔外科学会雑誌. 2024. 70. 8. 327-335
Soichiro Ishikawa, Masanari Umemura, Rina Nakakaji, Akane Nagasako, Kagemichi Nagao, Yuto Mizuno, Kei Sugiura, Mitomu Kioi, Kenji Mitsudo, Yoshihiro Ishikawa. EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma. Communications Biology. 2024. 7. 1
Toshinori Iwai, Masaki Hirabayashi, Mitomu Kioi, Kenji Mitsudo. Intraoral approach for oral floor reconstruction with the submandibular gland flap. Journal of dental sciences. 2024. 19. 1. 656-658
Satomi Sugiyama, Toshinori Iwai, Mitomu Kioi, Kenji Mitsudo. Occipital Artery Arising from the Superior Aspect of the Carotid Bifurcation: A Rare Anatomical Variant. INDIAN JOURNAL OF SURGERY. 2023

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MISC (172)：

大屋貴志, CHEN Xuefei, 石川聡一郎, 竹田敦, 大橋伸英, 林雄一郎, 林雄一郎, 小栗千里, 小泉敏之, 來生知, et al. Analysis of nutritional status of 119 patients treated with retrograde superselective chemoradiotherapy for tongue cancer. 日本口腔外科学会雑誌. 2024. 70. 8
小栗千里, 南山周平, 北島大朗, 矢島康治, 大屋貴志, 小泉敏之, 岩井俊憲, 來生知, 光藤健司. 下顎歯肉扁平上皮癌T4症例における手術療法と術前超選択的動注化学放射線療法の比較検討. 頭頸部癌. 2023. 49. 2. 212-212
大屋貴志, 陳雪霏, 石川聡一郎, 南山周平, 矢島康治, 小栗千里, 小泉敏之, 岩井俊憲, 來生知, 光藤健司. 舌癌に対する逆行性超選択的動注化学放射線療法の治療効果と食事摂取状況の評価. 日本口腔科学会雑誌(Web). 2022. 71. 4
関原和正, 関原和正, 中島慎太郎, 中島慎太郎, 中島慎太郎, 星野大輔, 來生知. 骨髄細胞の流入と口腔癌幹細胞による治療抵抗性の分子機構. がんと代謝研究会プログラム&抄録集. 2022. 8th
吉井悠, 來生知, 杉浦圭, 杉浦圭, 光藤健司. 口腔扁平上皮癌におけるSIRT6の役割について. 頭頸部癌. 2022. 48. 2

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Patents (2)：

Inhibition of post-radiation tumor growth by an inhibitor of vasculogenesis
Inhibition of post-radiation tumor growth.

Education (1)：

1998 - 2002 Yokohama City University Graduate Graduate School of Medicine

Professional career (2)：

PhD (Yokohama City University)
DDS (Nippon Dental University)

Work history (7)：

2021/04 - 現在 The Nippon Dental University School of Life Dentistry at Tokyo Department of Oral and Maxillofacial Surgery Visiting Professor
2021/04 - 現在 The Nippon Dental University School of Life Dentistry at Niigata Department of Oral and Maxillofacial Surgery Visiting Professor
2020/04 - 現在 Yokohama City University Hospital Dentistry/Oral and Maxillofacial Surgery/Orthodontics Professor
2013/04 - 2020/03 Yokohama City University Graduate School of Medicine Department of Oral and Maxillofacial Surgery Associate professor
2010/04 - 2013/03 Yokohama City University Graduate School of Medicine Department of Oral and Maxillofacial Surgery Lecturer

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Committee career (10)：

2021/04 - 現在口腔がん診療ガイドライン策定委員
2020/04 - 現在 Cancers Editorial Board Member
2019/04 - 現在 Japanese Journal of Clinical Oncology Reviewer Board Member
2018/07 - 現在日本口腔外科学会評議員
2017/07 - 現在 BioMed Research International (subject; Oncology) Editorial Board Member

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Awards (4)：

2017/04 - 日本口腔科学会総会・学術集会指名報告
2011/10 - 日本口腔外科学会総会優秀口演賞
2011/04 - 横浜医学会研究奨励賞
2010/09 - Radiation Research Society SIT Award

Association Membership(s) (8)：

THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER , 日本口腔科学会 , JAPAN SOCIETY FOR ORAL TUMORS , JAPAN SOCIETY FOR HEAD AND NECK CANCER , THE JAPANESE CANCER ASSOCIATION , JAPANESE SOCIETY OF ORAL AND MAXILLOFACIAL SURGEONS , Radiation Research Society , American Association for Cancer Research

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