Isoo Noriko

Research field (2)： Neurology , Neuroscience - general

Research keywords (10)：エクソソーム , 病原性タンパク伝播 , アルツハイマー病 , 運動ニューロン , GluN2Bサブユニット , NMDA受容体 , 皮質脊髄路 , シナプス除去 , シナプス可塑性 , シナプス形成

Research theme for competitive and other funds (3)：

2022 - 2025 エクソソームの輸送先選択性に基づきタウの伝播阻止を目指すアルツハイマー病治療
2020 - 2023 The effect of locus coeruleus-noradrenergic dysfunction on brain environment in Alzheimer's disease
2011 - 2014 Development, plasticity, and its critical period of the corticospinal synapses

Papers (20)：

Haruaki Sato, Kensaku Kasuga, Noriko Isoo, Toshihiro Hayashi, Takeshi Ikeuchi, Yukiko Hori, Taisuke Tomita. Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion. Neuroscience research. 2023. 193. 63-70
Isoo Noriko, Kawata Kentaro, Iso-o Naoyuki, Hori Yukiko, Tomita Taisuke, Hayashi Toshihiro. Uptake of tau-containing exosomes by neuronal cells(タイトル和訳中). The Journal of Physiological Sciences. 2022. 72. Suppl.1. 123-123
Kawata Kentaro, Isoo Noriko, Iso-o Naoyuki, Hori Yukiko, Tomita Taisuke, Hayashi Toshihiro. タウ蛋白質を含むエクソソーム亜集団の同定(Identification of a subpopulation of exosomes containing tau proteins). 臨床神経学. 2022. 62. Suppl. S415-S415
Iso-o N, Komatsuya K, Tokumasu F, Isoo N, Ishigaki T, Yasui H, Yotsuyanagi H, Hara M, Kita K. Malaria Parasites Hijack Host Receptors From Exosomes to Capture Lipoproteins. Frontiers in Cell and Developmental Biology. 2021. 9
Isoo Noriko, Murabe Naoyuki, Kameda Hiroshi, Fukuda Satoshi, Ikeda Miki, Teramoto Sayaka, Hayashi Toshihiro, Kwak Shin, Sakurai Masaki. 特定のプール内脊髄運動ニューロンの分離運動ニューロンにおける遺伝子発現の多様性(Isolation of spinal motoneurons of a defined pool: diversity in gene expressions of motoneurons). The Journal of Physiological Sciences. 2020. 70. Suppl.1. S134-S134

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MISC (17)：

佐藤玄謙, 春日健作, 磯尾紀子, 林俊宏, 堀由起子, 池内健, 富田泰輔. APP依存的な新規タウ分泌現象の発見. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1P-358
磯尾紀子, 林俊宏, 富田泰輔, 磯尾直之. アルツハイマー病におけるエクソソームの輸送機構の解明-治療への応用とバイオマーカー探索. 三井住友海上福祉財団研究結果報告書集. 2021. 25
Isoo, N, Murabe, N, Fukuda, S, Teramoto, S, Hayashi, T, Kwak, S, Sakurai, M. Isolation of defined spinal motoneuron for profiling gene expression. 60th Annual Meeting of the Japanese Society of Neurology,. 2019. 59. Suppl. S394-S394
Takae Ohno, Mutsumi Isowaki, Noriko Isoo, Naoyuki Murabe, Hitoshi Maeda, Satoshi Fukuda, Noboru Yoshioka, Masayoshi Mishina, Masaki Sakurai. Developmental shift of NMDA receptor subunits is essential for closing the critical period in corticospinal synapse elimination. NEUROSCIENCE RESEARCH. 2011. 71. E232-E232
Noriko Isoo, Takae Ohno, Naoyuki Murabe, Noboru Yoshioka, Masaki Sakurai. Dynamics of presynaptic structures and axons in the development of corticospinal innervation in vitro: Analysis by live imaging. NEUROSCIENCE RESEARCH. 2011. 71. E334-E334

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Work history (1)：

2016/04 - 現在 Teikyo University School of Medicine

Awards (3)：

2019/11 - 武田薬品工業株式会社 COCKPI-T Funding
2019/10 - 帝京大学医学部 2018年度Best Teacher Award
2018/11 - 三井住友海上福祉財団研究助成

Association Membership(s) (6)：

Society for Neuroscience , THE JAPANESE SOCIETY OF INTERNAL MEDICINE , JAPAN SOCIETY FOR DEMENTIA RESEARCH , PHYSIOLOGICAL SOCIETY OF JAPAN , THE JAPAN NEUROSCIENCE SOCIETY , JAPANESE SOCIETY OF NEUROLOGY

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