- 2017 - 2020 Development of evaluation methods for drug-induced liver injury based on both chemical structure/biological reactivity of drugs and individual factors
- 2014 - 2017 Differentiation of human iPS cells into hepatocytes and enterocytes: Development of first pass effect assessment model
- 2013 - 2017 Development of a model for the monitoring ontogenic expression of CYP3A by used of secreted reporter-expressing iPS cells
- 2009 - 2011 A new study of enzyme induction involved in pharmacokinetic : Identification of molecular mechanism for a novel enzyme induction
- 2005 - 2006 Novel protective mechanisms for cholestatic hepatotoxicity-application to drug improving hepatic function
- 2003 - 2004 Bile acids, key compounds for the mechanistic analyses of hepatotoxicity, and nuclear receptor interaction
- 2003 - 2003 直接的なPXR活性化のみがCYP3Aタイプ酵素誘導の機序ではない
- 2002 - 2003 脳特異的発現新規スルホトランスフェラーゼのアンチセンスmRNA法を用いた機能解析
- 2001 - 2002 Human characteristic mechanism of enzyme induction and the prediction
- 2000 - 2001 In vivo Molecular Mechanism of Human CYP3A Induction Involved in Drug Interaction
- 2000 - 2001 Grapefruit juice-drug interaction and the prediction
- 1999 - 2000 Analysis of mechanism for thalidomide-induced teratogenicity using knock-out mice
- 1997 - 1998 Role of intestinal oxidative metabolism on first pass effect
- 1995 - 1997 Development of as table expression system for human drug metabolizing enzymes
- 1996 - 1996 ヒト発がん感受性に関するアリルアミン硫酸転移酵素の遺伝子の単離と多型性解析
- 1995 - 1995 薬物によって誘導される肝特異的P450の遺伝子活性化機構の解析
- 1993 - 1994 Establishment of high sensitive Salmonella tester strains expressing mammalian acetvltransferase and sulfotransferase
- 1993 - 1994 Analysis of human interindividual and racial differeness of drug response and metabolism : Approach by the method of diagnosis by gene analysis
- 1993 - 1993 癌原物質の活性化を行うヒト肝スルホトランスフェラーゼの構造と遺伝的多型の解析
- 1991 - 1992 Assessment of human drug metabolism by expression of cytochrome P-450 in yeasts.
- 1990 - 1992 Regulation of expression of cytochrome P-450 by hormonal factor in primary cultured rat hepatocytes.
- 1989 - 1989 薬物代謝に関与するチトクロ-ムb_5のクロ-ニングと発現
- 1987 - 1987 下垂体因子による常在型および薬物被誘導型チトクロームP-450の発現とその調節
- 1985 - 1986 Analysis of mechanism of neonatal imprinting of drug-metabolizing enzymes of rat liver
- 1985 - 1986 Molecular mechanism of development and regulation of sex-specific cytochrome P-450 in rat liver
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