Kohji Hizume

Affiliation and department：

Research field (1)： Molecular biology

Research theme for competitive and other funds (15)：

2024 - 2027 ヒストンリサイクリングにおける染色体高次構造の役割 ~人工染色体を用いた解析から
2022 - 2025 ヒストンの受け渡し活性測定系の開発から探索するヒストンリサイクルの分子機構
2021 - 2024 Roles and their molecular mechanisms of replication barrier zones programmed on chromosome for genome stability maintenance
2019 - 2023 複製新生鎖へのクロマチン形成機構の探索:AFMによる新生鎖クロマチンの可視化解析
2012 - 2017 Molecular-scale functional visualization of bio- and nano-materials by AFM functional probes

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Papers (27)：

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MISC (6)：

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Lectures and oral presentations (19)：

In vitro analysis of the interaction of Mcm2 N-terminal region (Mcm2N) with histones: Mcm2N interacts with core histones ((H3-H4)2 + H2A-H2B hexamer) and releases the histones in the presence of Nap1.
(The 46th Annual Meeting of the Molecular Biology Society of Japan 2023)
Biochemical reconstitution and AFM (atomic force microscopy) observation of the protein-DNA complexes involved in DNA replication
(The 16th International Symposium on Bioscience and Nanotechnology 2018)
Molecular mechanism of DNA replication fork pausing at the barriers
(The 41st Annual Meeting of the Molecular Biology Society of Japan 2018)
DNA複製の“停止”に関する研究におけるAFMの応用例
(日本顕微鏡学会走査型プローブ顕微鏡分科会 “バイオ分野へのSPM応用” 2018)
CMG helicase activity on chromatinized DNA and at the replication fork barrier
(ConBio2017 2017)

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Education (2)：

Professional career (2)：

Work history (4)：

2018/01 - 現在 Saitama Medical University Biomedical Research Center Assistant Professor
2010/04 - 2017/12 National Institute of Genetics Assistant Professor
2008/01 - 2010/03 Kyoto University Graduate School of Biostudies Assistant Professor
2001/04 - 2007/12 Kyoto University Graduate School of Biostudies Research Associate

Association Membership(s) (1)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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