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J-GLOBAL ID：201301025555991898
Update date: Apr. 16, 2025 Uosaki Hideki
Uosaki Hideki
Jichi Medical University Division of Functional Biochemistry, Department of Biochemistry, School of Medicine
About Jichi Medical University Division of Functional Biochemistry, Department of Biochemistry, School of Medicine
Job title： Professor
Homepage URL (2)： https://www.jichi.ac.jp/kinou/ , https://www.jichi.ac.jp/kinou/index_en.html
Research keywords (10)：
心筋症
, 遺伝子治療
, ゲノム編集
, Regenerative Medicine
, Stem Cell Biology
, Transcriptome Analysis
, Maturation
, Differentiation
, Cardiomyocytes
, Pluripotent Stem Cells
Research theme for competitive and other funds (24)： - 2023 - 2028 次世代医療を目指した再生・細胞医療・遺伝子治療研究開発拠点
- 2023 - 2026 Elucidation of the mechanism of myocardial energy metabolism regulation by NC compound, a KLF5 inhibitor with a beneficial effect on heart failure.
- 2022 - 2026 疾患基盤となるサルコメアとミトコンドリア相互制御機構の解明
- 2022 - 2025 Analysis of myocardial energy metabolism using an ATP visualization model in the progression of hereditary cardiomyopathy
- 2021 - 2024 哺乳類の出生の異時性に基づく心筋再生機構の解明
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- 魚崎英毅, CHANTHRA Nawin. 心筋細胞の成熟制御メカニズムと再生医療への展開. カレントテラピー. 2024. 42. 1. 39-44
- 徳山 剛士, 魚崎 英毅. 疾患iPS細胞を用いたミトコンドリア病の病態・創薬研究. 生体の科学. 2023. 74. 5. 396-397
- Tomohiro Hino, Satoshi N Omura, Ryoya Nakagawa, Tomoki Togashi, Satoru N Takeda, Takafumi Hiramoto, Satoshi Tasaka, Hisato Hirano, Takeshi Tokuyama, Hideki Uosaki, et al. An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis. Cell. 2023. 186. 22. 4920-4935
- Takafumi Hiramoto, Yuji Kashiwakura, Morisada Hayakawa, Nemekhbayar Baatartsogt, Nobuhiko Kamoshita, Tomoyuki Abe, Hiroshi Inaba, Hiroshi Nishimasu, Hideki Uosaki, Yutaka Hanazono, et al. PAM-flexible Cas9-mediated base editing of a hemophilia B mutation in induced pluripotent stem cells. Communications Medicine. 2023. 3. 1
- 徳山剛士, 魚崎英毅. iPS細胞を用いたミトコンドリア病の病態解明. 実験医学. 2023. 41. 5. 720-726
- 阿部 朋行, 柴田 宏昭, 魚崎 英毅, 原 弘真, ボラジギン・サラントラガ, 長尾 慶和, 花園 豊. 大型動物胎仔を用いたヒト臓器再生技術 ヒツジで作るヒト造血幹細胞. Organ Biology. 2019. 26. 3. 87-87
- 原 弘真, 伊藤 拓哉, 菱川 修司, 中野 和明, 阿部 朋行, 柴田 宏昭, 魚崎 英毅, 渡邊 將人, 國田 智, 長嶋 比呂志, et al. SCIDピッグの長期飼育 再生医療・細胞治療評価系の確立をめざして. Organ Biology. 2019. 26. 3. 89-89
- 原 弘真, 菱川 修司, 伊藤 拓哉, 阿部 朋行, 柴田 宏昭, 魚崎 英毅, 國田 智, 花園 豊. ピッグ同種輸血の試み. Organ Biology. 2019. 26. 3. 121-121
- 細胞外マトリックス、成熟心筋細胞製造方法、及び心筋細胞成熟キット
- 心筋細胞の成熟方法、心筋細胞の成熟度評価方法、成熟心筋細胞の純化方法、心筋細胞成熟度評価装置、心筋細胞成熟度評価プログラム、及び心筋細胞成熟キット
- ゲノム編集方法、組成物、細胞、細胞製剤、及び細胞製剤の製造方法
- 新規心筋細胞マーカー
- 環状デプシペプチドの新規使用方法
- Stem Cells: Latest Advances
Springer Nature 2021 ISBN:3030770516 - モデル動物の作製と利用-循環器疾患2021
エル・アイ・シー 2021 - Pluripotent Stem-Cell Derived Cardiomyocytes. (In: Yoshida Y. (eds), Methods in Molecular Biology, vol 2320.)
Humana, New York, NY 2021 - Cardiac Regeneration using Stem Cells (eds., Fukuda K. & Yuasa S.)
CRC press 2013 - Embryonic Stem Cells: The Hormonal Regulation of Pluripotency and Embryogenesis (eds., Atwood C.)
InTech 2011
-
Identification of Transcriptional Factors and Nuclear Receptors Regulating Cardiomyocyte Maturation in vitro
(Weinstein Conference 2024 2024) -
Development of Cardiomyopathy Variant Knock-in Mouse Strains for Gene Therapy Proof-of-Concept.
(ASGCT 27th Annual Meeting 2024) -
多能性幹細胞由来心筋細胞の成熟化と疾患モデルへの挑戦
(第101回日本生理学会大会 2024) -
Gene Therapy for Mybpc3 Mutant Cardiomyopathy Models
(2024) -
Where are We with the Gene Therapy for Cardiomyopathy?
(MIS-KOREA 2024 2024)
- 2006 - 2011 Kyoto University Graduate School of Medicine
- 1998 - 2004 Hokkaido University School of Medicine
- 2025/04 - 現在 Jichi Medical University Division of Functional Biochemistry, Department of Biochemistry, School of Medicine Professor
- 2017/12 - 2025/03 Jichi Medical University Center for Molecular Medicine, Division of Regenerative Medicine Associate Professor
- 2016/09 - 2017/11 Jichi Medical University Center for Molecular Medicine, Division of Regenerative Medicine Lecturer
- 2011/06 - 2016/08 Johns Hopkins University School of Medicine, Division of Cardiology Research Fellow
- 2011/04 - 2011/05 Kyoto University Center for iPS research and application Research Fellow
- 2018/03 - Hokkaido University School of Medicine Alumni Association Furate Young Investigator Award
- 2015/12 - BMB Travel Grants for Early Career Researchers in Abroad
- 2015/11 - American Heart Association BCVS Abstract Travel Grant
- 2015/05 - Weinstein Conference Travel Award
- 2014/05 - Weinstein Conference Travel Award
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