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J-GLOBAL ID：201301025913132401   Update date: Apr. 10, 2025

Kojima Nobuhiko

コジマ ノブヒコ | Kojima Nobuhiko
Affiliation and department：
Yokohama City University School of Science Graduate School of Nanobioscience Department of Life and Environmental System Science

About Yokohama City University School of Science Graduate School of Nanobioscience Department of Life and Environmental System Science


Job title： Professor
Other affiliations (2)：
  • Yokohama City University  Advisor to the President
  • Yokohama City University  Career Support Center   Director
Homepage URL  (2)： http://regenbio.sci.yokohama-cu.ac.jp ,  http://regenbio.sci.yokohama-cu.ac.jp/index_e.html
Research field  (3)： Nano/micro-systems ,  Biomaterials ,  Biomedical engineering
Research keywords  (20)： Inherited Metabolic Diseases ,  Phenylketonuria ,  Red Blood Cell Carrier ,  Methylcellulose Method ,  Giant Spheroid ,  Micro Physiological Systems (MPS) ,  Liquid Liver ,  Organoid ,  Multicellular Spheroid ,  Aggregate ,  Pancreatic Islet ,  Self-organization ,  Tissue Unit ,  Optical Tweezers ,  Avidin-Biotin Reaction ,  Hetero Tissue Unit ,  Tissue Engineering ,  Avidin-Biotin Binding ,  Liver Tissue Engineering ,  Micro Device
Research theme for competitive and other funds  (11)：
  • 2022 - 2026 ヒト脳マイクロパソフィジオロジカルシステムズ:脳疾患の生体模倣と創薬研究への応用
  • 2022 - 2024 Development of a spheroid containing a water ghost as a pump
  • 2022 - 2024 Development of new carriers utilizing with transplantation rejection mechanism in amnion membrane derived cells
  • 2020 - 2023 Development of microphysiological systems for evaluating inflammation
  • 2019 - 2022 Development of human multicellular spheroidal blood-brain barrier models for drug development studies
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Papers (45)：
  • Kenjiro Hanaoka, Takayuki Ikeno, Shimpei Iwaki, Sayaka Deguchi, Kazuo Takayama, Hiroyuki Mizuguchi, Fumiya Tao, Nobuhiko Kojima, Hisashi Ohno, Eita Sasaki, et al. A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT). Science Advances. 2024
  • Fumiya Tao, Keita Kitamura, Sanshiro Hanada, Kazuyuki Sugimoto, Tomomi Furihata, Nobuhiko Kojima. Rapid and Stable Formation Method of Human Astrocyte Spheroid in a High Viscous Methylcellulose Medium and Its Functional Advantages. Bioengineering (Basel, Switzerland). 2023. 10. 3
  • Fumiya Tao, Sanshiro Hanada, Kazuya Matsushima, Hiroshi Arakawa, Naoki Ishida, Yukio Kato, Saya Okimura, Tomohisa Watanabe, Nobuhiko Kojima. Enhancement and maintenance of hepatic metabolic functions by controlling 3D aggregation of cryopreserved human iPS cell-derived hepatocyte-like cells. Journal of Bioscience and Bioengineering. 2023. 135. 2. 134-142
  • Takuya Ono, Rei Noguchi, Yuki Yoshimatsu, Yooksil Sin, Nobuhiko Kojima, Tadashi Kondo. Development of different organ derived decellularized tissue gels that support in vitro tumor cell behavior in a tumor type-specific manner. Journal of Electrophoresis. 2021. 65. 1. 33-37
  • Fumiya Tao, Kanae Sayo, Kazuyuki Sugimoto, Shigehisa Aoki, Nobuhiko Kojima. Development of a tunable method to generate various three-dimensional microstructures by replenishing macromolecules such as extracellular matrix components and polysaccharides. Scientific reports. 2020. 10. 1. 6567-6567
ｍore...
MISC (135)：
  • KOJIMA Nobuhiko. Development of Organoid Assay. The Journal of The Institute of Electrical Engineers of Japan. 2024. 144. 4. 209-212
  • 岸谷 有倭, 小島 伸彦. 液体肝臓の酵素活性改善に向けた検討. 日本生物工学会大会講演要旨集. 2023. 2023年. 94-94
  • 渡辺 吉彦, 松島 壱弥, 小島 伸彦. 空隙構造の異なる肝スフェロイドを用いた薬物応答性の評価(Evaluation of drug response using liver spheroids with different pore structure). The Journal of Toxicological Sciences. 2022. 47. Suppl. S199-S200
  • 渡辺 吉彦, 松島 壱弥, 小島 伸彦. 空隙構造の異なる肝スフェロイドを用いた薬物応答性の評価(Evaluation of drug response using liver spheroids with different pore structure). The Journal of Toxicological Sciences. 2022. 47. Suppl. S199-S200
  • 小島 伸彦. 先天代謝異常症に対する新しい治療戦略 先天代謝異常症の治療を可能とする液体肝臓の開発. 日本先天代謝異常学会雑誌. 2021. 37. 94-94
ｍore...
Patents (6)：
ｍore...
Education (3)：
  • 1998 - 2001 The University of Tokyo Graduate School of Science Biophysics and Biochemistry
  • 1996 - 1998 Osaka University Graduate School of Engineering Applied Biological Engineering
  • 1992 - 1996 Osaka University School of Engineering Applied Biological Engineering
Professional career (1)：
  • Ph.D. (The University of Tokyo)
Work history (9)：
  • 2024/10 - 現在 Yokohama City University Advisor to the President
  • 2024/04 - 現在 Yokohama City University Career Support Center Director
  • 2024/04 - 現在 Yokohama City University Graduate School of Nanobioscience Professor
  • 2022/07 - 2025/03 Ecocell Co., Ltd. Chief Technology Officer, Director
  • 2013/04 - 2024/03 Yokohama City University Graduate School of Nanobioscience Associate Professor
Show all
Committee career (6)：
  • 2023/04 - 現在 The Japanese Society for Alternatives to Animal Experiments Board of delegates
  • 2022/01 - 現在 The Japanese Society for Alternatives to Animal Experiments SDGs Working Group
  • 2017/04 - 現在 Japanese Society for Living Systems Design Research Organizing Committee
  • 2022/01 - 2023/11 The Japanese Society for Alternatives to Animal Experiments 3Rs Awareness Committee
  • 2021/05 - 2023/03 The Japanese Society for Alternatives to Animal Experiments Board of Councilors
Show all
Awards (13)：
  • 2024/10 - Japan Chemical Industry Association JCIA LRI Award at the Japanese Society for Alternatives to Animal Experiments Enhancement and maintenance of hepatic metabolic functions by controlling 3D aggregation of cryopreserved human iPS cell-derived hepatocyte-like cells.
  • 2024/06 - The Society for Biotechnology, Japan Excellent Paper Award - Selected Papers (2024) Enhancement and maintenance of hepatic metabolic functions by controlling 3D aggregation of cryopreserved human iPS cell-derived hepatocyte-like cells
  • 2022/09 - Biotech Grand Prix 2022 Euglena Award Accelerating the Design of Cell Societies to Contribute to the Biotechnology Industry
  • 2021/12 - The 2021 INNO-vation Program Nominated for the "Generation Award" Category Bringing the Joy of Eating to Patients with Phenylketonuria through Liquid Liver!
  • 2021/10 - The 4th MedTech Grand Prix KOBE 2021 ROHTO Award Development of Liquid Liver
Show all
Association Membership(s) (7)：
The Japanese Society of Toxicology ,  The Society for Biotechnology, Japan ,  The Japanese Society for Alternatives to Animal Experiments ,  Japanese Society for Living Systems Design Research ,  The Japanese Society for Regenerative Medicine ,  The Japanese Society for the Research of Hepatic Cells ,  The Molecular Biology Society of Japan
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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