Rchr
J-GLOBAL ID:201301028446627921
Update date: May. 18, 2024
Itoh Yukihiro
イトウ ユキヒロ | Itoh Yukihiro
Affiliation and department:
Homepage URL (1):
https://www.sanken.osaka-u.ac.jp/labs/cmc/yukihiro-itoh/
Research field (1):
Pharmaceuticals - chemistry and drug development
Research keywords (4):
Biological organic chemistry
, ケミカルバイオロジー
, 創薬化学
, 有機化学
Research theme for competitive and other funds (7):
- 2022 - 2026 クリックケミストリーに基づく生物活性化合物創製法の確立
- 2021 - 2024 Development of innovative drug candidates by target guided synthesis
- 2020 - 2023 RNA分解誘導化合物の開発とその薬学的応用
- 2019 - 2021 ユビキチン化タンパク質ならびにその連結様式を解析するためのケミカルプローブ創製
- 2017 - 2020 Identification of artificial ubiquitin compounds and their application study
- 2014 - 2017 Discovery of ubiquitin-activating enzyme inhibitors designed based on its catalytic mechanism
- 2012 - 2014 Discovery of lysine-specific demethylase 1 Inhibitors based on enzymatic mechanism
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Papers (77):
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Siyao Ni, Yuri Takada, Takaaki Ando, Shengwang Yu, Yasunobu Yamashita, Yukari Takahashi, Miho Sawada, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki. Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule. Bioorganic & medicinal chemistry letters. 2024. 105. 129759-129759
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Yosuke Ota, Yukihiro Itoh, Yuri Takada, Yasunobu Yamashita, Chenliang Hu, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki. Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells. Bioorganic & medicinal chemistry. 2024. 100. 117632-117632
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Mitsuhiro Terao, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki. Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity. Bioorganic & medicinal chemistry. 2024. 98. 117579-117579
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Haiyan Li, Ayako Kawatake-Kuno, Hiromichi Inaba, Yuka Miyake, Yukihiro Itoh, Takatoshi Ueki, Naoya Oishi, Toshiya Murai, Takayoshi Suzuki, Shusaku Uchida. Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice. Neuron. 2024
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Yuri Takada, Kyohei Adachi, Yuka Fujinaga, Yasunobu Yamashita, Yukihiro Itoh, Takayoshi Suzuki. A Structure-Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 1. Chemical & pharmaceutical bulletin. 2024. 72. 2. 155-160
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MISC (9):
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Toru Komatsu, Yukihiro Itoh. Challenges of young chemists to be global. Yakugaku Zasshi. 2019. 139. 2. 185-186
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Youhei Sohma, Yukihiro Itoh. Chemical biology for pharmaceutical sciences (novel ideas for “drug” discovery). Yakugaku Zasshi. 2017. 137. 3. 281-282
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Shuichiro Tsukamoto, Yoshitake Sakae, Yukihiro Itoh, Takayoshi Suzuki, Yuko Okamoto. Study of Ligand Binding Selectivity of Histone Deacetylases by Replica-Exchange Umbrella Sampling Molecular Dynamics Simulations. BIOPHYSICAL JOURNAL. 2016. 110. 3. 544A-545A
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伊藤幸裕, 粟飯原圭佑, MELLINI Paolo, 東條敏史, 太田庸介, 津元裕樹, SOLOMON Viswas Raja, ZHAN Peng, 鈴木美紀, 小笠原大介, et al. ヒドラジン構造を持つペプチド性LSD1阻害薬の創製. メディシナルケミストリーシンポジウム講演要旨集. 2016. 34th
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石川 稔, 伊藤 幸裕, 内藤 幹彦, 橋本 祐一. 2-II-24 細胞内レチノイド結合タンパク質の分解を誘導するレチノイン酸連結化合物の創製(一般演題,日本ビタミン学会第62回大会発表要旨). ビタミン. 2010. 84. 4. 189-189
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Professional career (1):
Work history (3):
- 2020/06 - 現在 Osaka University The Institute of Scientific and Industrial Research associate professor
- 2020/06 - 現在 Kyoto Prefectural University of Medicine
- 2019/04 - 2020/05 Kyoto Prefectural University of Medicine
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