MARI GOTOH

ゴトウマリ | MARI GOTOH

Affiliation and department：

Research field (1)： Molecular biology

Research keywords (1)：生理活性脂質

Research theme for competitive and other funds (4)：

2023 - 2026 新規リゾホスファチジン酸構造異性体の定量法確立と生理活性解明
2019 - 2022 神経保護作用を持つ生理活性脂質の新規メカニズムの解明: 脳血管障害治療への応用
2014 - 2018 Analysis of lipid mediator signaling that increases hyaluronic acid synthesis and the effect of lipid mediator on cell senescence
2010 - 2012 Investigation of the mechanism of TRP channel mediated by a lipid mediator, 2ccPA, via LPA receptor

Papers (60)：

Wataru Nagata, Mari Gotoh, Akiho Koizumi, Keiko Fukasawa, Keiichi Nakagawa, Yasushi Satoh, Toshiaki Ishizuka. Two-carba cyclic phosphatidic acid treatment promotes phenotypic switch from M1 to M2 microglia and prevents behavioral abnormalities in a mouse model of neuropsychiatric systemic lupus erythematosus. Human cell. 2023
Misaki Endo, Mari Gotoh, Mari Nakashima, Yuka Kawamoto, Shiho Sakai, Kimiko Murakami-Murofushi, Kei Hashimoto, Yasunori Miyamoto. 2-Carba cyclic phosphatidic acid regulates blood coagulation and fibrinolysis system for repair after brain injury. Brain research. 2023. 148511-148511
Wataru Nagata, Akiho Koizumi, Keiichi Nakagawa, Sayaka Takahashi, Mari Gotoh, Yasushi Satoh, Toshiaki Ishizuka. Treatment with lysophosphatidic acid prevents microglial activation and depression-like behaviours in a murine model of neuropsychiatric systemic lupus erythematosus. Clinical and experimental immunology. 2023. 212. 2. 81-92
Rino Takei, Mari Nakashima, Mari Gotoh, Misaki Endo, Kei Hashimoto, Yasunori Miyamoto, Kimiko Murakami-Murofushi. 2-carba-cyclic phosphatidic acid modulates astrocyte-to-microglia communication and influences microglial polarization towards an anti-inflammatory phenotype. Neuroscience letters. 2023. 797. 137063-137063
Shibaike Yuki, Sano Katsura, Gotoh Mari. Endoplasmic reticulum stress inhibits adipocyte differentiation of mesenchymal stem cells. Cytologia. 2023. 88. 3

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MISC (33)：

咲間妙, 子, 後藤一雄, 赤間, 剛, 大井, 亀田貴寛, 後藤真, 里, 崎原ことえ, et al. 帝京大学臨床検査学科における交換留学プログラムの紹介. 臨床検査学教育. 2024. 16. 1. 88-90
後藤真里, 芝池由樹, 佐野桂, 岡村浩司. ヒトの老化で観察される遺伝子発現およびDNAメチル化変化の解析. 日本ヒト細胞学会学術集会. 2023. 41st
橋本恵, 藤井愛, 藤井愛, 佐藤楓果, 佐藤楓果, 片桐沙紀, 石川将己, 中島大輔, 紺野亮, 川島祐介, et al. 老化促進マウスSAMP8における認知障害誘発機構の解明. 日本ヒト細胞学会学術集会. 2023. 41st
深澤桂子, 田中誠也, 三宅亮介, 石川将己, 後藤真里. オートタキシンによるリゾホスファチジルコリンからのβ型リゾホスファチジン酸生合成経路の解明. 脂質生化学研究. 2022. 64. 241-243
TAKEI Rino, ENDO Misaki, NAKASHIMA Mari, HASHIMOTO Kei, GOTOH Mari, MIYAMOTO Yasunori, MIYAMOTO Yasunori, MUROHUSHI Kimiko. The effect of 2-carba-cyclic phosphatidic acid on the communication between astrocyte and microglia. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th

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Patents (5)：

Books (3)：

Lectures and oral presentations (73)：

“Biosynthesis of β-lysophosphatidic acid from cyclic phosphatidic acid by autotaxin, and bioactivity of a novel β-lysophosphatidic acid analogue, 2-carba-lysophosphatidic acid”
(The Lysophospholipid and Related Mediators Conference: From Bench to Clinic-Virtual 2021)
The effect of cyclic phosphatidic acid derivative 2-carba-cPA on repair of brain stab wound
(2020)
“2-carba cyclic phosphatidic acid contributes to the neuroprotection in stab-wounded cerebral cortex via regulation of astrocytes”
(American Society for Cell Biology, Washington D.C 2019)
「マウス大脳皮質穿刺損傷時のアストロサイトにおける2ccPAのテネイシンC発現への効果」
(第6回Matricellフォーラム、仙台 2019)
2 carba cyclic phosphatidic acid suppresses the activation of astrocytes in the stab wounded mouse cerebral cortex
(2019)

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Education (4)：

Professional career (2)：

Work history (9)：

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