Rchr
J-GLOBAL ID:201301042735235430
Update date: Feb. 03, 2025 Ohishi Tomokazu
オオイシ トモカヅ | Ohishi Tomokazu
Affiliation and department: Job title:
Senior Researcher
Homepage URL (1): http://kaken.nii.ac.jp/d/r/50442546.ja.html Research field (4):
Tumor biology
, Pharmaceuticals - chemistry and drug development
, Tumor diagnostics and therapeutics
, Laboratory animal science
Research keywords (15):
Red blood cells
, Phospholipid remodeling
, bacteriology
, microbiology
, Monoclonal antibody
, Cancer metastasis
, Tea
, PARP
, Poly(ADP-ribosyl)ation
, Tankyrase
, Cancer
, Tmour
, Molecular targeted therapy
, Chemical biology
, Tumor-stromal cell interactions
Research theme for competitive and other funds (12): - 2024 - 2029 Development of cancer-specific antibodies for clinical application using CasMab technology
- 2022 - 2025 Establishment of Therapeutic Strategies Targeting Stromal-Derived Factor PAI-1, Which Determines Liver Metastasis in Colorectal Cancer
- 2023 - 2024 Exploration of Novel Drug Seeds Using Secondary Metabolites from Cordyceps Fungus and Mouse Tumor Models
- 2021 - 2024 Development of Advanced Cancer-Specific Antibody Creation Technologies and Their Medical Applications Targeting Refractory Cancers (Principal Investigator: Yukinari Kato)
- 2022 - 2023 Elucidation of the Significance of Cancer Cell Membrane Phospholipid Remodeling by Lysophosphatidylcholine Acyltransferase 1 (LPCAT1)
- 2021 - 2022 Therapeutic Strategies Targeting Liver Stromal Cell-Derived Factors for Liver Metastasis of Colorectal Cancer
- 2021 - 2022 Development of Antibody Drugs for Personalized Medicine of Colorectal Cancer with KRAS Gene Mutations
- 2018 - 2021 Identification and functional analysis of a liver stromal cell-derived factor contributing to liver metastasis of colorectal cancer cells
- 2016 - 2019 Drug development of new bioactive compounds induced p53-dependent growth suppression
- 2017 - 2018 Development of H. pylori Therapeutics Targeting Pyrimidine Biosynthetic Enzymes
- 2013 - 2016 The molecular mechanisms and regulation of acquisition of tumor invasive abilities through actin cytoskeleton remodeling
- 2011 - 2012 Elucidation of the mechanism of cancer cell invasion through a novel actin cytoskeleton-associated protein TAB182
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Papers (104): -
Mika K. Kaneko, Hiroyuki Suzuki, Tomokazu Ohishi, Takuro Nakamura, Miyuki Yanaka, Tomohiro Tanaka, Yukinari Kato. Antitumor Activities of a Humanized Cancer-Specific Anti-HER2 Monoclonal Antibody, humH2Mab-250 in Human Breast Cancer Xenografts. International Journal of Molecular Sciences. 2025
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Tomohiro Tanaka, Hiroyuki Suzuki, Tomokazu Ohishi, Mika K. Kaneko, Yukinari Kato. A Cancer-Specific Anti-Podoplanin Monoclonal Antibody, PMab-117-mG2a Exerts Antitumor Activities in Human Tumor Xenograft Models. Cells. 2024
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Kenichiro Ishikawa, Hiroyuki Suzuki, Tomokazu Ohishi, Takuro Nakamura, Miyuki Yanaka, Guanjie Li, Tomohiro Tanaka, Akira Ohkoshi, Manabu Kawada, Mika Kaneko, et al. Antitumor activities of anti-CD44 monoclonal antibodies in mouse xenograft models of esophageal cancer. Oncology Reports. 2024. 52. 5
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Kenichiro Ishikawa, Hiroyuki Suzuki, Tomokazu Ohishi, Guanjie Li, Tomohiro Tanaka, Manabu Kawada, Akira Ohkoshi, Mika K. Kaneko, Yukio Katori, Yukinari Kato. Anti-CD44 Variant 10 Monoclonal Antibody Exerts Antitumor Activity in Mouse Xenograft Models of Oral Squamous Cell Carcinomas. International Journal of Molecular Sciences. 2024. 25. 17. 9190-9190
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Hiroyuki Suzuki, Tomokazu Ohishi, Tomohiro Tanaka, Mika K Kaneko, Yukinari Kato. Anti-HER2 Cancer-Specific mAb, H2Mab-250-hG1, Possesses Higher Complement-Dependent Cytotoxicity than Trastuzumab. International journal of molecular sciences. 2024. 25. 15
more... MISC (86): -
Junjiro Yoshida, Tomokazu Ohishi, Manabu Kawada. Drug Discovery Targeting Cancer Energy Metabolism Using Inhibitors of Metabolic Enzymes. Clinical Oncology, edited by the Editorial Committee of Clinical Oncology. 2023. 31. 1. 102-108
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Asano Teizo, Ohishi Tomokazu, Suzuki Hiroyuki, Kawada Manabu, Kaneko Mika K., Kato Yukinari. Antitumor activity of a novel anti-HER3 monoclonal antibody in mouse xenografts of colorectal cancer. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 2-O-056
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Takei Junko, K. Kaneko Mika, Ohishi Tomokazu, Asano Teizo, Kawada Manabu, Harada Hiroyuki, Kato Yukinari. Development of a monoclonal antibody for CD44-expressing oral cancers. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 2-O-D1-4
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Tomokazu Ohishi, Junjiro Yoshida, Manabu Kawada. The existing state of drug development targetting the tumor-stromal cell interactions. Experimental medicine. 2021. 39. 12
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Tomokazu Ohishi, Manabu Kawada. Involvement of the fibrinolytic system regulator in the liver metastasis of colorectal cancer. Abstracts of the Japanese Cancer Association Annual Meeting. 2021. 30th
more... Books (5): - CLINICAL ONCOLOGY(Jan./2023), Drug discovery targeting cancer energy metabolism
Kagaku Hyoronsha 2023
- Experimental Medicine (Vol.39 No.12) Tackling the Cancer Microenvironment at the Single-Cell Level
Yodosha 2021
- Microbes and Immunity
Kenpakusha 2020
- Molecular Target Therapy of Cancer, Cancer treatment targeting telomeres and telomerase
Nanzando 2008 ISBN:9784525420413
- The CELL, October 2007 Issue, Regulation of the spindle by Aurora kinases
New Science Company 2007
Lectures and oral presentations (7): -
Establishment and Research of an In Vivo Screening System for Anticancer Drugs Using Cordyceps Culture Fluid
(2023)
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The Role and Regulation of Cancer-Stroma Interaction in Liver Metastasis of Colorectal Cancer
(32nd Annual Meeting of the Japanese Association for Metastasis Research, Symposium “Cutting-Edge Biopharmaceutical Development Techniques to Conquer Cancer Metastasis 2023)
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Understanding the Components and Health Functions of Tea
(Open Seminar by NPO China Tea Culture Association 2023)
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New Potential Health Benefits of Tea: COVID-19, Cancer, and Lifestyle-Related Diseases
(Open Symposium on the Power of Tea in the With-COVID Era 2023)
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New Potential Functions of Polyphenols
(2022)
more... Education (1): - 2002 - 2006 The University of Tokyo Graduate School of Medicine
Professional career (1): - Doctor of Medicine (Ph.D.) (The University of Tokyo)
Work history (4): - 2022/04 - 現在 Institute of Microbial Chemistry(BIKAKEN), Microbial Chemistry Research Foundation Laboratory of Oncology, Numazu brunch
- 2015/04 - 2022/03 Institute of Microbial Chemistry(BIKAKEN), Microbial Chemistry Research Foundation Numazu branch
- 2014/04 - 2015/03 Tokyo Metropolitan Institute of Medical Science
- 2006/04 - 2014/03 Japanese Foundation for Cancer Research
Committee career (5): - 2024/09 - 現在 The Japanese Cancer Association Councilor
- 2024/05 - 現在 Public Relations Committee Working Group Japanese Cancer Association
- 2018/04 - 現在 International Symposium on Cancer Chemotherapy Committee member
- 2017/04 - 現在 Japanese Association for Molecular Target Therapy of Cancer Councilor
- 2022/01 - 2023/01 Secretariat of the 32nd New Drug Discovery Meeting
Awards (7): - 2021/05 - The Japanese Association for Molecular Target Therapy of Cancer Excellent Presentation Award
- 2020/01 - 20th Kanto Hormone and Cancer Research Group
- 2017/03 - Cosmo Bio Co., LTD. Cosmo Bio Award
- 2016/12 - The Japanese Society of Clinical Pharmacology and Therapeutics Excellent Presentation Award
- 2016/06 - The Japanese Association for Molecular Target Therapy of Cancer Research Encouragement Award
- 2014/06 - CBSM International Joint Symposium Best Poster Award
- 2009/04 - Cold Spring Harbor Laboratory Travel Stipend Award for Young Investigators
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Association Membership(s) (5):
The Japanese Association for Metastasis Research
, International Symposium on Cancer Chemotherapy
, The Japanese Association for Molecular Target Therapy of Cancer
, Japanese Cancer Association
, The Japanese Society of Clinical Pharmacology and Therapeutics
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