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J-GLOBAL ID：201301043604625248 Update date: Mar. 27, 2025

Kenya Kamimura

カミムラケンヤ | Kenya Kamimura

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Affiliation and department：
Job title： Professor
Other affiliations (2)：

Niigata University School of Medicine Department of General Medicine Professor
Niigata University Medical and Dental Hospital Gastroenterology

Homepage URL (1)： http://kaken.nii.ac.jp/d/r/00579146.ja.html

Research field (3)： Tumor diagnostics and therapeutics , Gastroenterology , Pharmacology

Research keywords (19)：非ウイルスベクター•プラスミド , 遺伝子治療前臨床研究 , 肝臓癌 , 消化器癌 , ゲノム編集 , General Medicine , Inter-Organ Communication , Hydrodynamic Gene Delivery , Non-viral Gene Delivery , Translational Research , Gene Therapy , Gastroenterology & Hepatology , 肝臓 , 遺伝子治療 , 凝固活性 , ハイドロダイナミック遺伝子導入法 , 血友病 , 大動物 , 血管造影手技

Research theme for competitive and other funds (37)：

2024 - 2027 肝細胞への選択的取り込みが可能な間葉系幹細胞由来細胞外小胞の開発
2023 - 2027 Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy
2023 - 2027 Development of Organ- and Cell-specific In Vivo Genome Editing Technique as a Novel Approach for Cancer Gene Therapy
2022 - 2025 Development of novel treatment for non-alcoholic steatohepatitis by the research for the mechanism of regulation of liver fat accumulation
2021 - 2025 自律神経を介する臓器連関の非アルコール性脂肪性肝疾患の病態への関与の解析と新規治療法への応用

2021 - 2024 Application of the Autonomic Nervous Management for NAFLD Treatment

2021 - 2024 Pancreatic cancer biomarker research by the exosome proteome analysis of the HGD rat pancreatic cancer model

2021 - 2024 遺伝子導入によるラット胆管癌モデルの確立と浸潤能評価による病態マーカー開発

2020 - 2024 Development of Hydrodynamics-based Gene Therapy for the Pancreatic Cancer

2020 - 2023 診断困難な消化管運動異常症と機能性消化管疾患との境界症例の病態解明

2019 - 2022 Development of a treatment to improve fibrosis and elucidation of carcinogenesis mechanisms in improved NASH model MC4RKO mice

2019 - 2022 間葉系幹細胞およびコラゲナーゼを用いた難治性食道狭窄に対する治療法の開発

2017 - 2021 肝臓特異的ハイドロダイナミック法による核酸医薬送達と肝癌遺伝子治療法への応用

2017 - 2021 HGD for HCC Gene Therapy

2021 - Development of biomarker and effective therapeutic methods for pancreatic cancer using our newly developed animal model

2018 - 2020 Effect of Organ Communication on Liver Function upon the Liver Injury

2017 - 2020 Mechnism for improvemnt of pathophysiological condition in NASH treated with 7,8-Dihydroxyflavone

2017 - 2019 The Prevention of Fibrosis by the Elucidation of Interaction between Lymphoid Follicles and Activated Liver Stellate Cell.

2016 - 2019 Efficacy of gelatin hydrogels incorporating triamcinolone acetonide for prevention of esohageal fibrosis after endoscopic submucosal dissection

2016 - 2019 Development of gene therapy for liver cirrhosis utilizing MMP13

2016 - 2018 Development of Medaka NASH Model and Hepatocarcinogenesis

2014 - 2018 Hydrodynamic Gene Delivery to Non-human Primates

2014 - 2017 Basic research to develop next generation cell therapy for improvement of liver fibrosis.

2013 - 2016 Development of Medaka Model for Analysis of Angiogenesis and Kupffer cell

2014 - 2015 Development of Novel Therapy for Hand-foot Syndrome using Dried Bonito

2014 - Development of Clinically Applicable Hydrodynamic Delivery System for Molecules and Cell Delivery to Target Organs

2013 - 2014 産官学連携による遺伝子注入器の開発と日本発の新規遺伝子治療への応用

2011 - 2013 Development of the controllable parameter deriving method of hydrodynamic gene therapy equipment

2011 - 2013 Hydrodynamic Gene Delivery to Non-human Primates

2013 - 肝細胞癌のシスプラチンに対する感受性マーカーの検証

2012 - 2012 海外研究者招聘

2010 - 2012 HGD

2010 - 2011 ハイドロダイナミック遺伝子導入法による遺伝子治療ーイヌ血友病モデルでの検証ー

2011 - ハイドロダイナミック法による新規遺伝子治療法の開発-非ヒト霊長類を用いた検証-

2010 - HGD

2010 - 研究助成金

2010 - 基礎科学研究助成

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Papers (210)：

Natsuki Ishikawa, Yusuke Watanabe, Yuichirou Maeda, Tomoaki Yoshida, Naruhiro Kimura, Hiroyuki Abe, Akira Sakamaki, Hiroteru Kamimura, Takeshi Yokoo, Kenya Kamimura, et al. Human placental extract improves liver cirrhosis in mice with regulation of macrophages and senescent cells. Regenerative therapy. 2025. 28. 509-516
Akira Sakamaki, Kunihiko Yokoyama, Hanako Yamazaki, Takuya Wakabayashi, Yuichi Kojima, Kentaro Tominaga, Atsunori Tsuchiya, Kenya Kamimura, Junji Yokoyama, Shuji Terai. Small Intestinal Bacterial Overgrowth Is a Predictor of Overt Hepatic Encephalopathy in Patients with Liver Cirrhosis. Journal of clinical medicine. 2025. 14. 5
Tatsuo Kanda, Reina Sasaki-Tanaka, Naruhiro Kimura, Hiroyuki Abe, Tomoaki Yoshida, Kazunao Hayashi, Akira Sakamaki, Takeshi Yokoo, Hiroteru Kamimura, Atsunori Tsuchiya, et al. Pruritus in Chronic Cholestatic Liver Diseases, Especially in Primary Biliary Cholangitis: A Narrative Review. International journal of molecular sciences. 2025. 26. 5
Shunta Yakubo, Hiroyuki Abe, Yawen Li, Marina Kudo, Atsushi Kimura, Takuya Wakabayashi, Yusuke Watanabe, Naruhiro Kimura, Toru Setsu, Takeshi Yokoo, et al. Dasatinib and Quercetin as Senolytic Drugs Improve Fat Deposition and Exhibit Antifibrotic Effects in the Medaka Metabolic Dysfunction-Associated Steatotic Liver Disease Model. Diseases (Basel, Switzerland). 2024. 12. 12
Kyutaro Koyama, Akira Sakamaki, Shinichi Morita, Itsuo Nagayama, Marina Kudo, Yuto Tanaka, Naruhiro Kimura, Yoshihisa Arao, Hiroyuki Abe, Kenya Kamimura, et al. Maid gene dysfunction promotes hyperobesity via the reduction of adipose tissue inflammation in Mc4r gene-deficient mice. Scientific reports. 2024. 14. 1. 21126-21126

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MISC (245)：

上村顕也, 大越麻理奈, 木村淳史, 寺井崇二. メダカを用いた脂肪性肝疾患の多臓器合併症の検討. 肝臓. 2024. 65. Suppl.1. A332-A332
坂牧僚, 横山邦彦, 若林拓哉, 阿部寛幸, 土屋淳紀, 上村顕也, 寺井崇二. 顕性肝性脳症の発症予測における,呼気中水素・メタン分析によるSIBO診断の有用性の検討. 肝臓. 2024. 65. Suppl.1. A410-A410
阿部寛幸, 弥久保俊太, 渡邉雄介, 木村成宏, 横尾健, 坂牧僚, 上村博輝, 土屋淳紀, 上村顕也, 寺井崇二. ダサチニブ及びケルセチンは老化細胞除去剤としてMASHメダカモデルにおいて老化細胞を減少させ病態改善に寄与する. 肝臓. 2024. 65. Suppl.1. A514-A514
坂牧僚, 横山邦彦, 若林拓哉, 阿部寛幸, 土屋淳紀, 上村顕也, 寺井崇二. 顕性肝性脳症の発症予測における,呼気中水素・メタン分析によるSIBO診断の有用性の検討. 肝臓. 2024. 65. Suppl.1. A410-A410
坂巻僚, 横山邦彦, 若林拓哉, 小島雄一, 川田雄三, 冨永顕太郎, 水野研一, 上村顕也, 寺井崇二. 小腸内細菌異常増殖症(SIBO)の病態と臨床顕性肝性脳症の発症予測における、呼気中水素・メタン分析によるSIBO診断の有用性の検討. 日本小腸学会学術集会プログラム・抄録集. 2023. 61回. 26-26

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Patents (6)：

時間-脈管内圧制御に基づく細胞内薬物送達システム及び細胞内薬物送達方法
膵臓選択的なハイドロダイナミック遺伝子導入法
野生型ラットの膵臓へのヒト膵癌関連遺伝子の導入による膵癌モデル動物の開発と利用
レトロゾールの線維化抑制効果
手足症候群の予防または改善用組成物

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Books (9)：

地域発患者の診かた : 救急の技で一般外来診療は進化する
クリニコ出版 2022 ISBN:9784910396194
Nucleic Acid-Based Therapy: Development of a Nonviral-Based Delivery Approach
Intech Open 2019
The Management of Constipation: Current Status and Future Prospects
Intech Open 2019
Gene Therapy and Cell Therapy Through the Liver, Chapter 8, Image-Guided Hydrodynamic Gene Delivery to the Liver: Toward Clinical Applications
Springer 2016
Advances and Challenges in the Delivery of Oligonucleotide-based Therapies, 2014 Ch 8, Hydrodynamic Gene Delivery
Future Science 2015

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Lectures and oral presentations (70)：

自律神経経路を基軸とする脂肪性肝疾患の脂質代謝制御機構の解明と治療薬探索
(JDDW2023 統合プログラム1(S) 肥満関連消化器疾患治療の現状と課題 2023)
Applicability of Hydrodynamic Gene Delivery Procedure to Gene Therapy and Animal Disease Model Development
(JSGCT 2023 2023)
脂肪肝炎:今後の展開自律神経経路が制御する多臓器連関の解析と脂肪肝炎制御への展開
(日本消化器病学会総会 2022)
肝移植適応疾患の病態解明と診療展開肝障害に伴う臓器連関による血中セロトニン濃度変化と病態の検討肝不全の病態変化を推測するマーカーの樹立へ
(日本消化器病学会総会 2022)
老化と消化器がんの病態・診療 Relative Dose Intensityに注目した高齢者レンバチニブ治療の安全性と有効性
(日本消化器病学会総会 2022)

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Professional career (1)：

医学博士 (新潟大学)

Work history (7)：

2023/11 - 現在 Graduate School of Medical and Dental Sciences, Niigata University Division of Human Resource Development for Community Medicine/Department of General Medicine, Niigata University School of Medicine Professor
2010/01 - 現在 Niigata University Medical and Dental Hospital
2020/12 - 2023/10 Niigata University School of Medicine Department of General Medicine A specially-appointed professor
2019/04 - 2020/11 Niigata University Medical and Dental Hospital Division of Gastroenterology and Hepatology Lecturer
2015/08 - 2019/03 Graduate School of Medical and Dental Sciences, Niigata University Division of Gastroenterology and Hepatology Assistant Professor

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Committee career (11)：

2022 - 現在日本肝臓学会学会評議員
2022 - 現在日本遺伝子細胞治療学会幹事
2021 - 現在日本遺伝子細胞治療学会教育・広報委員会委員
2021 - 現在日本遺伝子細胞治療学会評議員
2021 - 現在新潟県地域医療対策協議会『総合的な診療能力をもつ医師の養成・確保等に関する研究班』班員

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Awards (12)：

2017 - Niigata Prefectural Medical Association Excellence in Research Award
2016 - Asian Pacific Association for the Study of the Liver Young Investigator’s Award
2015/05 - American Society of Gene & Cell Therapy Travel Grant Image-guided, Liver-targeted Hydrodynamic Gene Delivery in Dogs. Preclinical Assessment of Effectiveness and Safety of the Procedure
2015/04 - The Japanese Society of Internal Medicine Young Researcher's Award from the Japanese Soceity of Internal Medicine
2015 - 日本膵臓病研究財団膵臓病研究奨励賞

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Association Membership(s) (13)：

日本プライマリ・ケア連合学会 , 日本医学教育学会 , 遺伝子デリバリー研究会 , American Association for the Study of Liver Diseases , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM , The American Society of Gene & Cell Therapy , Japan Society of Gene and Cell Therapy , THE JAPANESE CANCER ASSOCIATION , JAPAN GASTROENTEROLOGICAL ENDOSCOPY SOCIETY , The Japan Society of Hepatology , The Japanese Society of Gastroenterology , THE JAPANESE SOCIETY OF INTERNAL MEDICINE

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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