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J-GLOBAL ID：201301053341151543 Update date: Mar. 07, 2025

Naohisa Wada

ワダナオヒサ | Naohisa Wada

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/60380466.ja.html

Research field (3)： Regenerative dentistry and dental engineering , Community dentistry , Conservative dentistry and endodontics

Research keywords (28)：歯根膜 , 幹細胞 , マラッセの上皮遺残 , 歯周組織再生 , セメント質 , ヒト歯根膜細胞 , 象牙質タンパク , ハイドロキシアパタイト , 未分化なヒト歯根膜細胞 , 炭酸アパタイト , ヒト , 遺伝子 , hTERT , TGF-β1 , 歯内療法学 , SV40 large T抗原 , 細胞・組織 , SCIDマウス , 未分化な歯根膜細胞株 , 人工歯根 , STRO-1 , 再生 , β-TCP , 歯学 , プロテオーム解析 , 伸展力 , 再生医学 , CD146

Research theme for competitive and other funds (32)：

2023 - 2026 Elucidation of differentiation regulating mechanism by SPARC-related factors expressed in the dental papilla, and attempt of tooth regeneration
2022 - 2026 歯周組織発生過程の模倣を基盤とするハイブリッド構造体の創成と歯周組織再生への応用
2022 - 2025 Delivery of a therapeutic protein for periodontal regeneration from grid sheets
2022 - 2025 根尖病巣複合Biofilmの性状解明と天然成分エッセンシャルオイルの有用性
2022 - 2025 舌苔細菌叢による難治性悪性腫瘍早期発見の可能性についての研究

2021 - 2024 Development of a new drug for periodontal regeneration based on the activation of neural crest cells

2019 - 2023 オミックス解析を用いた歯根膜発生機構の解明と幹細胞誘導型組織再生技術への応用

2019 - 2022 口腔扁平上皮癌における亜鉛トランスポーターの役割と機能に関する研究

2017 - 2022 Establishment of the the method to develop 3D-periodontal ligament from iPS cells, and its application for artificial tooth root

2018 - 2021 Generation of a compound that has the potential to induce the formation of PDLSCs using iPS- and genome-based drug discovery technology.

2017 - 2021 Development of the new periodontal ligament regeneration method based on iPS-derived neural crest cells

2017 - 2020 Multiple analysis of association between periodontitis-related bacteria and gastrointestinal cancer

2017 - 2020 The clarification of mechanisms and treatments of dysgeusia induced by anticancer drug

2017 - 2019 Development of novel pulp capping material which can cover the extensive dentin defect.

2015 - 2019 The study of tissue engineering utilizing periodontal ligament stem cell induced by tropic factors

2014 - 2017 Development of the dentin-repairing therapy regulating the calcium-sensing receptor

2014 - 2017 The study on the effects of Semaphorin3A on dentin regeneration using dental pulp stem cells

2013 - 2017 Development of bioactive resin containing the capacity to induce periodontal tissue formation

2014 - 2015 新規覆髄材の開発を目的としたβig-h3の解析

2013 - 2015 The novel strategy to regenerate periodontal ligament tissue using iPS cells

2012 - 2015 Develpment of novel therapy for periodontium regeneration using periodontal iPS cells

2012 - 2014 Could human dental pulp stem cell be an alternative cell source for periodontal tissue regeneration of reimplanted tooth?

2012 - 2014 The analyses of interleukin-11 on the regeneration of periodontal ligament tissues

2011 - 2014 Establishment of periodontal tissue regeneration method by using of novel PDLSC cell surface marker and PDL marker

2011 - 2012 Development of successful intentional replantation

2010 - 2012 Development of next-generation artificial tooth root including periodontal ligament

2010 - 2012 Development of novel periodontal tissue therapy targeting for regeneration of periodontal ligament.

2010 - 2011 歯根膜幹細胞に特異的に発現する新規細胞表面抗原マーカーおよび増殖因子の同定

2009 - 2011 What is required for periodontal ligament regeneration?

2006 - 2008 What are the factor and the cells to be involved in the periodontal regeneration?

2005 - 2006 マラッセの上皮遺残はセメント質形成に関与しているか?

2001 - 2002 歯根膜における破骨細胞形成抑制因子OPG/OCIFの発現および調節機構の解析

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Papers (103)：

孫偉浩, 祐田明香, 宮治裕史, 林佳文, 御手洗裕美, 王恕心, 冉子晴, 前田英史, 和田尚久. 酸化グラフェンを用いた細胞成長因子デリバリースキャフォールドの評価(Characterization of drag delivery using graphene oxide scaffold). 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2024. 161回. 151-151
王恕心, 御手洗裕美, 冉子晴, 祐田明香, 孫偉浩, 原口晃, 前田英史, 和田尚久. IGFBP3は歯胚発生と歯周組織のリモデリングに関与する. 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2023. 159回. 140-140
Keisuke Sanematsu, Masato Yamamoto, Yuki Nagasato, Yuko Kawabata, Yu Watanabe, Shusuke Iwata, Shingo Takai, Kiyoshi Toko, Toshiro Matsui, Naohisa Wada, et al. Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3. Communications biology. 2023. 6. 1. 340-340
Naati Fakatava, Hiromi Mitarai, Asuka Yuda, Akira Haraguchi, Hiroko Wada, Daigaku Hasegawa, Hidefumi Maeda, Naohisa Wada. Actin alpha 2, smooth muscle, a transforming growth factor-β1-induced factor, regulates collagen production in human periodontal ligament cells via Smad2/3 pathway. Journal of dental sciences. 2023. 18. 2. 567-576
Shoko Tomooka, Emi Oishi, Masako Asada, Satoko Sakata, Jun Hata, Sanmei Chen, Takanori Honda, Kosuke Suzuki, Hiroshi Watanabe, Norihito Murayama, et al. Serum lipopolysaccharide-binding protein levels and the incidence of metabolic syndrome in a general Japanese population: the Hisayama Study. Journal of epidemiology. 2022

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MISC (24)：

稲井裕子, 野村義明, 寳田貫, 花田信弘, 和田尚久. 全身麻酔下手術前の診査における手術後肺炎発症のリスク因子. 口腔衛生学会雑誌. 2019. 69. 増刊. 159-159
Naohisa Wada, Atsushi Tomokiyo, Stan Gronthos, P. Mark Bartold. Immunomodulatory Properties of PDLSC and Relevance to Periodontal Regeneration. Current Oral Health Reports. 2015. 2. 4. 245-251
Atsushi Tomokiyo, Kim Hynes, Stan Gronthos, Naohisa Wada, P. Mark Bartold. Is There a Role for Neural Crest Stem Cells in Periodontal Regeneration?. Current Oral Health Reports. 2015. 2. 4. 275-281
長谷川大学, 和田尚久, 前田英史, 吉田晋一郎, 御手洗裕美, 門野内聡, 濱野さゆり, 祐田明香, 赤峰昭文. Wnt5aはRor2-JNKシグナルを介してヒト歯根膜幹細胞株の骨芽細胞様分化を抑制する. 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2014. 141回. 84-84
長谷川大学, 和田尚久, 前田英史, 吉田晋一郎, 門野内聡, 御手洗裕美, 濱野さゆり, 祐田明香, 赤峰昭文. Wnt5aはTGFβ1を介してヒト歯根膜細胞のコラーゲン線維形成を促進する. 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2014. 140回. 32-32

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Education (2)：

1998 - 2002 Kyushu University
1991 - 1997 Kyushu University School of Dentistry

Work history (6)：

2021/11 - 現在 Kyushu University
2015/04 - 現在 Kyushu University Hospital
2012/01 - 2015/03 Kyushu University
2010/04 - 2011/12 Kyushu University
2007/09 - 2010/03 The University of Adelaide School of Dentistry, Faculty of Health Science Postdoctoral Research Officer

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Association Membership(s) (8)：

国際歯科医学会 , 日本総合歯科学会 , 日本顕微鏡歯科学会 , 日本歯科医学教育学会 , 日本歯内療法学会 , 日本老年歯科医学会 , 日本再生医療学会 , 日本歯科保存学会

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