Taro Takami

Takami Taro | Taro Takami

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www.ichinai-yamaguchi.jp/

Research field (1)： Gastroenterology

Research keywords (21)：骨髄細胞 , 肝硬変症 , 肝発癌 , ゼブラフィッシュ , メダカ , 肝線維化 , 漢方薬 , Maid , 非アルコール脂肪肝炎 , 肝発がん , 修復再生療法 , 非アルコール性脂肪性肝炎 , 肝細胞癌 , Maid KO mice , 遺伝子治療 , HTVi法 , medaka , 遺伝子導入法 , ABMi療法 , 肝臓病 , 肝再生

Research theme for competitive and other funds (32)：

2024 - 2028 Novel therapeutic strategies to overcome intestinal fibrosis in Crohn's disease
2024 - 2027 Establishment of Mass Production Method and Functional Enhancement of Mesenchymal Stem Cells for Liver Regeneration Therapy
2023 - 2026 iPS細胞から誘導した間葉系幹細胞由来細胞外小胞によるセルフリー肝臓再生療法の開発
2023 - 2026 iPS細胞から誘導した間葉系幹細胞由来細胞外小胞によるセルフリー肝臓再生療法の開発
2023 - 2026 間葉系幹細胞の作用を洗練・集約化した抗線維化microRNA封入脂質ナノ粒子の開発

2022 - 2025 The cell identification research of bone marrow drived liver repaired cell in the new liver regeneration therapy

2020 - 2024 新規骨髄由来肝臓修復細胞による肝臓再生療法の開発

2020 - 2024 線維性腸管狭窄に対するメカニズムの解明と臨床応用への検討

2020 - 2023 The development research of liver regeneration therapy used bone marrow drived liver repaired cell

2020 - 2023 鉄除去により強制的に変化させた代謝を標的とした新規抗癌併用療法の開発

2020 - 2023 高感度メチル化解析法による新たな肝癌診断スクリーニング検査の構築

2020 - 2023 抗線維化作用増強exosomeを用いた継続型低侵襲肝臓再生療法の開発

2020 - 2023 肝予備能不良進行肝細胞癌に対する鉄キレート剤と再生療法によるハイブリッド療法開発

2018 - 2021 二種類の骨髄由来肝臓修復細胞による効率的な肝臓再生療法の開発

2017 - 2020 The development of liver regeneration therapy with higher therapeutic effects on liver cirrhosis using a middle-large size liver cirrhosis model.

2017 - 2020 Development of cell-free liver regeneration therapy with the anticipatory method to culture higher-quality MSCs for liver cirrhosis

2016 - 2019 Effects of a novel oral iron chelator on refractory digestive system cancers

2016 - 2018 Development of anti-fibrotic therapies for liver fibrosis by the regulation of Rho family GTPases of macrophages.

2015 - 2018 The analysis and identification of bome marrow drived liver repair cell

2014 - 2017 Basic research to develop next generation cell therapy for improvement of liver fibrosis.

2014 - 2017 Research and development for liver regeneration therapy with higher-therapeutic effects using the higher-functioning cultured bone marrow mesenchymal stem cells

2013 - 2017 Utility of herbal medicine for remission maintenance therapy of ulcerative colitis

2013 - 2016 Development of Medaka Model for Analysis of Angiogenesis and Kupffer cell

2012 - 2015 The analysis of small bone marrow drived liver repair cell

2012 - 2014 Development of the analytical method of the cancer stem cell using the ATP sensor in the cell

2012 - 2014 Basic studies into development of novel preventive and regenerative therapy for hepatocarcinogenic cirrhosis using bone marrow-derived cells having redox-regulatory capacity

2011 - 2012 Basic research for chronotherapy focused on liver regeneration andliver steatosis by circadian clock

2010 - 2012 The basic research of the development of future generation cell therapy used bone marrow derived liver repaid cell

2010 - 2012 Both Herbal medicine Bofu-tsusho-san (TJ-62) and Dai-saiko-to (TJ-8) prevent liver fibrosis and hepatocarcinogenesis in rat liver cirrhosis.

2010 - 2011 Development of new gene transfer system for small fish

2009 - 2010 非アルコール性脂肪性肝炎関連発癌に対する戦略的研究

2009 - 2010 Basic researches for developing new liver regeneration therapy using cultured autologous bone marrow derived cells in decompensated liver cirrhosis patients with hepatocellular carcinomas.

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Papers (272)：

Yuki Kunimune, Yutaka Suehiro, Issei Saeki, Yurika Yamauchi, Norikazu Tanabe, Toshihiko Matsumoto, Shingo Higaki, Ikuei Fujii, Chieko Suzuki, Naoko Okayama, et al. Combination Assay of Methylated HOXA1 with Tumor Markers Shows High Sensitivity for Detection of Early-Stage Hepatocellular Carcinoma. Liver cancer. 2024. 13. 5. 487-497
Katsuhiko Nakamura, Yutaka Suehiro, Koichi Hamabe, Atsushi Goto, Shinichi Hashimoto, Yuki Kunimune, Akiyo Ishiguro, Naoko Okayama, Tomohiro Fujii, Yukiko Nakahara, et al. A Novel Index Including Age, Sex, hTERT, and Methylated RUNX3 Is Useful for Diagnosing Early Gastric Cancer. Oncology. 2024. 1-14
Yukari Inoue, Akiyo Ishiguro, Yutaka Suehiro, Yuki Kunimune, Yuko Yamaoka, Shinichi Hashimoto, Katsuhiko Nakamura, Atsushi Goto, Koichi Hamabe, Toshihiko Matsumoto, et al. A novel index combining fecal immunochemical test, DNA test, and age improves detection of advanced colorectal adenoma. Cancer science. 2024
Shigeo Shimose, Issei Saeki, Tetsu Tomonari, Takanori Ito, Joji Tani, Yasuto Takeuchi, Naoki Yoshioka, Takehito Naito, Mamiko Takeuchi, Satoru Kakizaki, et al. Initial clinical experience with durvalumab plus tremelimumab in patients with unresectable hepatocellular carcinoma in real-world practice. Oncology letters. 2024. 28. 2. 397-397
Mitsuaki Nishioka, Koichi Hamabe, Yuki Kunimune, Masaki Kodama, Yukiko Nakahara, Naoko Okayama, Mika Tominaga, Hiromi Furutani, Fusako Ito, Tomohiro Fujii, et al. A case of asymptomatic infection of Ascaris suum identified by PCR-restriction fragment length polymorphism and DNA sequence analysis. Diagnostic microbiology and infectious disease. 2024. 110. 1. 116444-116444

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MISC (585)：

松本俊彦, 藤岡毅, 川本大樹, 山本直樹, 高見太郎. 自己完結型肝硬変再生療法の開発と間葉系幹細胞由来肝再生因子の探索. 日本再生医療学会総会(Web). 2024. 23rd
川本大樹, 松本俊彦, 山本直樹, 高見太郎. 肝臓再生療法における自己骨髄間葉系幹細胞由来細胞外小胞の作用機序の解析. 日本消化器病学会雑誌(Web). 2024. 121
江種真穂, 佐伯一成, 高木立哉, 森口笑衣, 下栗佳那美, 田平未希子, 西川寛子, 田邉規和, 山崎隆弘, 高見太郎. Comparison of treatment outcome between microwave ablation and radiofrequency ablation for hepatocellular carcinoma. 超音波医学 Supplement. 2024. 51
田邉規和, 佐伯一成, 江種真穂, 西山夏子, 藤岡毅, 川本大樹, 佐々木嶺, 西村達朗, 松本俊彦, 石川剛, et al. 当院における切除不能肝細胞癌に対するdurvalumab・tremelimumab併用療法の初期経験. 日本肝がん分子標的治療研究会プログラム・抄録集. 2024. 29th
西村達朗, 石川剛, 西山夏子, 川本大樹, 佐々木嶺, 田邊規和, 佐伯一成, 松本俊彦, 高見太郎. HVPGの非侵襲的代替マーカーの探索と長期予後の層別化. 日本消化器病学会雑誌(Web). 2024. 121

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Patents (10)：

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Professional career (1)：

医学博士 (山口大学)

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