Hirano Ikuo

ヒラノイクオ | Hirano Ikuo

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://www.exphem.med.tohoku.ac.jp/toppage.html

Research field (2)： Tumor biology , Medical biochemistry

Research keywords (5)： Erythropoiesis , Erythropoietin , Hypoxia , GATA1 , Leukemia

Research theme for competitive and other funds (9)：

2019 - 2023 ドライバー変異と協調して白血病発症を修飾する遺伝的素因の探索
2020 - 2022 Analysis of the regulation of early erythropoiesis by transcription factor GATA1 and erythropoietin signal
2017 - 2020 Development of novel erythropoiesis-stimulating agents that enhance erythropoietin gene expression
2015 - 2019 Multistep leukemogenesis caused by imbalanced GATA1 function
2014 - 2019 Systemic mechanisms of response to hypoxic stresses

Show all

Papers (30)：

Ikuo Hirano, Kanako Abe, James Douglas Engel, Masayuki Yamamoto, Ritsuko Shimizu. Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency. Experimental hematology & oncology. 2024. 13. 1. 23-23
Daishi Ishihara, Atsushi Hasegawa, Ikuo Hirano, James Douglas Engel, Masayuki Yamamoto, Ritsuko Shimizu. The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice. Experimental hematology & oncology. 2024. 13. 1. 24-24
Shimizu R, Hirano I, Hasegawa A, Suzuki M, Otsuki A, Taguchi K, Katsuoka F, Uruno A, Suzuki N, Yumoto A, et al. Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice. Commun Biol. 2023. 6
Taku Nakai, Yuma Iwamura, Koichiro Kato, Ikuo Hirano, Yotaro Matsumoto, Yoshihisa Tomioka, Masayuki Yamamoto, Norio Suzuki. Drugs activating hypoxia-inducible factors correct erythropoiesis and hepcidin levels via renal EPO induction in mice. Blood advances. 2023
Atsushi Hasegawa, Yuki Hayasaka, Masanobu Morita, Yuta Takenaka, Yuna Hosaka, Ikuo Hirano, Masayuki Yamamoto, Ritsuko Shimizu. Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding. Communications Biology. 2022. 5. 1

ｍore...

MISC (12)：

ｍore...

Lectures and oral presentations (13)：

低酸素非依存性のエリスロポエチン産生を異所的に誘導する化合物の探索
(第7回低酸素研究会学術集会 2019)
B cell development is influenced by expression of Gata1
(ConBio2017 2017)
腎臓におけるエリスロポエチン遺伝子制御機構の解明
(腎とエリスロポエチン研究会 2016)
マウスモデルを用いた白血病発症に関わる遺伝的素因の探索
(第89回日本生化学会大会 2016)
赤芽球系白血病の発症に寄与する遺伝的素因の探索
(第20回造血器腫瘍研究会 2016)

ｍore...

Professional career (2)：

Awards (4)：

Association Membership(s) (2)：

日本分子生物学会 , 日本生化学会

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page