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J-GLOBAL ID：201301058669114396 Update date: Jan. 20, 2025

Hirata Hiroshi

ヒラタヒロシ | Hirata Hiroshi

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Affiliation and department：
Job title：教授
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/60250958.ja.html

Research field (6)： Measurement engineering , Radiology , Pharmacology , Crystal engineering , Applied materials , Pharmaceuticals - analytical and physicochemistry

Research keywords (30)：電子スピン共鳴 , イメージング , 生体計測 , 共振器 , 電子常磁性共鳴 , ニトロキシルラジカル , MRI , 画像再構成 , マイクロ波共振器 , 周波数変調 , サーフェイス・コイル , 自動マッチング制御 , 磁界変調 , 共振尖鋭度 , 磁気共鳴 , 安定性 , 高周波磁界発生効率 , 空洞共振器 , スライス選択画像 , 実験動物 , 線形制御理論 , 平衡線路 , pH , 帰還制御 , マイクロ波発振器 , マウス , 脳 , 分光 , スペクトル , 一酸化窒素

Research theme for competitive and other funds (39)：

2024 - 2028 低強度超音波薬学:経頭蓋脳深部刺激による低体温状態誘導に関する技術基盤の構築
2022 - 2026 Oxygen and pH imaging of malignant tumors using electron paramagnetic resonance
2022 - 2025 Spatio-temporal dynamics analysis of cell death induction due to disruption of biometal homeostasis and its application to radiotherapy
2020 - 2025 Targetting of cancer-specific metabolic system for senolytic therapy
2021 - 2025 電子スピンでセンシングする悪性腫瘍の高精度酸素イメージング法の開発

2018 - 2023 Development of EPR in vivo tooth Dosimeter

2019 - 2022 Development of a novel radiotherapy targeting iron-dependent cell death ferroptosis

2019 - 2022 Development of a method of 3D oxygen and pH mapping of tumors using electron spin resonance spectroscopy

2018 - 2022 Development of multifunctional electron/nuclear magnetic resonance imaging

2018 - 2021 Analysis of radioresistance factors of tumors in radiotherapy by using MS imaging and ESR imaging techniques

2017 - 2020 Development of a novel therapy by targeting for cancer specific glutamine and acetate metabolism

2016 - 2018 Model experiments of partial pressure of oxygen-guided intensity modulated radiation therapy

2014 - 2018 Quantitative measurements of multi-parameter electron spin resonance imaging

2014 - 2017 Application of an in-vivo portable EPR dosimetry against radiation exposures

2014 - 2016 Development of low field EPR/NMR co-imaging system for biological samples

2011 - 2014 キラリティー磁気共鳴分子イメージング

2011 - 2013 Human application of in vivo EPR Dosimetry

2010 - 2012 Functional molecular imaging studies by rapid EPR imaging method

2008 - 2011 高速電子常磁性共鳴イメージング法の開発

2009 - 2011 Structural evaluation of stratum corneum investigated by electron spin resonance imaging

2009 - 2011 脳科学研究のための機能的電子スピン共鳴イメージング法の研究

2008 - 2010 スーパーレゾリューション電子常磁性共鳴イメージング法の開発

2007 - 2009 Functional imaging studies of small rodents by ESR・MRI combined system

2006 - 2008 Electron spin resonance imaging for brain/neuroscience studies

2005 - 2006 Molecular magnetic resonance imaging studies on ESR・MRI dual system

2004 - 2005 Development of a Highly Sensitive EPR Spectrometer for Brain Science Studies

2002 - 2004 Non-invasive analysis of dynamic state of reactive oxygen species in tissue and blood vessel of circulatory diseases

2002 - 2003 生体計測用超高感度電子スピン共鳴スペクトロスコピーの開発

2002 - 2003 Development of an EPR imager for the cerebral function analysis

2002 - 2003 生体ラジカル二重共鳴画像解析用共振デバイスと画像化システムの開発

2000 - 2002 Development of a FM-EPR instrument

2000 - 2001 実験動物による擾乱を自動補償する電子スピン共鳴スペクトロメーターの開発

1999 - 2001 Study of PEDRI (Proton Electron Double Resonance Imaging)

1998 - 1999 共振周波数高安定化1.2GHz電子スピン共鳴スペクトロメーター

1997 - 1998 Joint study on design and fabrication of HTS antenna and filter

1997 - 1998 In vio ESR oximetry for clinical use-Developments for mesuring oxygen tension in biological systems-

1996 - 1998 DEVELOPMENT OF 350MHz PULSED EPR SPECTROMETER

1995 - 1997 Study on miniaturized super-gain superconducting antenna

1994 - 1994 電子スピン共鳴計測用サーフェイスコイル型共振器の最適設計法に関する研究

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Papers (96)：

Yukihiro Arai, Mai Taguchi, Oki Mitarai, Ichiro Yamaguchi, Hideo Sato-Akaba, Shingo Matsumoto, Minoru Miyake, Hiroshi Hirata. Three-dimensional electron paramagnetic resonance (EPR) imaging of an X-ray-irradiated bovine tooth: A feasibility study. Radiation Measurements. 2025. 181. 107381
Jeonghun Oh, Chang Uk Koo, Jong In Park, Kwon Choi, Junyoung Lee, Hiroshi Hirata, Sung-Joon Ye. Accuracy enhancement of L-band EPR tooth dosimetry by implementing multiple harmonic detection. Radiation Measurements. 2024. 176. 107185
Koudai Sawami, Tatsuya Naganuma, Hana Yabe, Toshihiko Taki, Neil J. Stewart, Yoshiki Uchio, Norihiko Takeda, Noriyuki Hatae, Takuya Hashimoto, Hiroshi Hirata, et al. Parahydrogen-Induced ¹³C Hyperpolarizer Using a Flow Guide for Magnetic Field Cycling to Evoke ¹H-¹³C Spin Order Transfer Toward Metabolic MRI. IEEE Transactions on Biomedical Engineering. 2024. 71. 7. 2224-2231
Misa Oba, Mai Taguchi, Yohei Kudo, Koya Yamashita, Hironobu Yasui, Shingo Matsumoto, Igor A. Kirilyuk, Osamu Inanami, Hiroshi Hirata. Partial Acquisition of Spectral Projections Accelerates Four-dimensional Spectral-spatial EPR Imaging for Mouse Tumor Models: A Feasibility Study. Molecular Imaging and Biology. 2024. 26. 3. 459-472
Hideo Sato-Akaba, Tsukasa Sakai, Hiroshi Hirata. Generation of transmission wave with low AM noise for sub-GHz CW-EPR spectrometer. Journal of Magnetic Resonance. 2024. 360. 107633

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MISC (5)：

Hiroshi Hirata. Interview with Professor Hiroshi Hirata on the occasion of his IES Medal in Instrumentation and Methods Development 2024. epr news letters. 2024. 34. 3. 7-9
Hiroshi Hirata. Electron paramagnetic resonance imaging and its biomedical applications. Bunsei. 2019. 2019. 12. 538-544
Hiroshi Hirata. Introduction to In Vivo ESR Imaging. Bunkou Kenkyu. 2015. 64. 6. 573-581
HIRATA Hiroshi. Three-dimensional redox mapping using fast electron paramagnetic resonance imaging. Folia Pharmacologica Japonica. 2012. 140. 4. 146-150
H Hirata, ZW Luo. Erratum: Stability analysis and design of automatic frequency control system for in vivo EPR spectroscopy (vol 46, pg 1209, 2001). MAGNETIC RESONANCE IN MEDICINE. 2003. 49. 5. 977-977

Books (2)：

"Tumor Extracellular pH Mapping using Electron Paramagnetic Resonance: Techniques and Applications" in: Annual Reports on NMR Spectroscopy, Volume 112, W. S. Price (ed.)
Academic Press, San Diego, CA, USA 2024 ISBN:9780443297526
“Resonators for Clinical Electron Paramagnetic Resonance” in: Measuring Oxidants and Oxidative Stress in Biological Systems, L. J. Berliner and N. L. Parinandi (eds.)
Springer Nature Switzerland AG 2020

Lectures and oral presentations (18)：

In vivo extracellular pH mapping using electron paramagnetic resonance
(Asia-Pacific EPR/ESR Symposium 2024 (APES 2024) 2024)
IES Medal Award Lecture: Low-field EPR instrument development for in vivo applications
(Rocky Mountain Conference: EPR Symposium 2024)
Tumor extracellular pH mapping using electron paramagnetic resonance: Recent progress and applications
(23rd International Society of Magnetic Resonance Conference (ISMAR 2023) 2023)
Technological advances in resonators for in vivo and clinical EPR
(EPR 2023: International Conference on EPR Spectroscopy and Imaging of Biological Systems 2023)
Overview of EPR-based extracellular pH mapping using multi-harmonic detection
(Asia-Pacific EPR/ESR Symposium 2022 (APES 2022) 2022)

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Education (3)：

1990 - 1993 Tokyo Institute of Technology Graduate School of Multidisciplinary Science and Technology Department of Applied Electronics
1988 - 1990 Yamagata University Graduate School of Engineering Department of Electrical Engineering
1984 - 1988 Tohoku Institute of Technology Department of Communication Engineering

Professional career (1)：

博士(工学) (東京工業大学)

Work history (9)：

2019/04 - 現在 Faculty of Information Science and Technology Proessor
2008/10 - 2019/03 Hokkaido University Graduate School of Information Science and Technology
2015/03 - 2015/03 Jagiellonian University, Poland Faculty of Biochemistry, Biophysics and Biotechnology Visiting Professor
2007/04 - 2008/09 Yamagata University Graduate School of Science and Engineering
1996/04 - 2007/03 Yamagata University Faculty of Engineering

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Committee career (6)：

2024/07 - 2025/03 ENC-ISMAR Joint Conference 2025 Program Committee Member
2018/07 - 2024/06 International Society on Oxygen Transport to Tissue Executive Committee Member
2022/02 - 2024/02 The Society of Electron Spin Science and Technology Vice President
2018/01 - 2020/12 International EPR (ESR) Society Vice President (Asia-Pacific)
2012/01 - 2015/12 電子スピンサイエンス学会理事

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Awards (4)：

2024/01 - International EPR/ESR Society IES Medal in Instrumentation and Methods Development
2019/06 - International Society for Magnetic Resonance in Medicine Distinguished Reviewer, Magnetic Resonance in Medicine
2018/07 - International Society for Magnetic Resonance in Medicine Distinguished Reviewer for Magnetic Resonance in Medicine
2003/10 - 電子スピンサイエンス学会奨励賞生命科学研究のための電子スピン共鳴装置の開発

Association Membership(s) (6)：

THE INSTITUTE OF ELECTRONICS, INFORMATION AND COMMUNICATION ENGINEERS. , International EPR (ESR) Society , International Society for Magnetic Resonance in Medicine , THE SOCIETY OF ELECTRON SPIN SCIENCE AND TECHNOLOGY , International Society of Magnetic Resonance (ISMAR) , International Society on Oxygen Transport to Tissue (ISOTT)

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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