Rchr
J-GLOBAL ID:201301064488621008
Update date: Oct. 31, 2024 KINOSHITA Chisato
キノシタ チサト | KINOSHITA Chisato
Affiliation and department: Research field (3):
Pharmacology
, Genomics
, Nervous system function
Research keywords (10):
NOVA1
, non-coding RNA
, taurine
, Circadian Rhythm
, Neurodegenerative disease
, RNA binding protein
, GTRAP3-18
, EAAC1
, microRNA
, Glutathione
Research theme for competitive and other funds (14): - 2023 - 2026 Analysis of novel peptide nucleic acids against neurodegeneration
- 2021 - 2024 マイクロバブル超音波法を用いた核酸薬経鼻投与による神経変性疾患の新規治療戦略
- 2020 - 2023 プリン体および尿酸の骨髄幹細胞活性に与える影響
- 2021 - 2022 Neuroprotection of taurine against oxidative stress through miRNA regulation
- 2019 - 2020 神経保護作用を呈する核酸薬の脳内送達法開発による神経変性疾患治療戦略
- 2017 - 2019 Epigenetic regulation of novel neuroprotective proteins
- 2017 - 2018 新規神経保護タンパク質群のエピジェネティック制御
- 2016 - 2018 microRNAの分子機構解析による神経変性疾患の分子標的時間治療
- 2015 - 2017 Unraveling the neuroprotective mechanism of rhythmic microRNA
- 2015 - 2016 概日リズムを呈するmicroRNAによる神経保護効果
- 2014 - 神経変性疾患の分子標的時間治療を目指したmicroRNAの分子機構解析
- 2014 - 神経変性疾患の時間治療を目指すmicroRNA解析
- 2014 - 視交叉上核非依存性体内時計に関与するmicroRNA
- 2006 - 脳機能障害の発生におけるドパミンD2 受容体の役割の解明
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Papers (22): -
Wattanaporn Bhadhprasit, Chisato Kinoshita, Nobuko Matsumura, Koji Aoyama. Erythroid Differentiation Regulator 1 as a Regulator of Neuronal GSH Synthesis. Antioxidants. 2024
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Nobuko Matsumura, Chisato Kinoshita, Wattanaporn Bhadhprasit, Toshio Nakaki, Koji Aoyama. A purine derivative, paraxanthine, promotes cysteine uptake for glutathione synthesis. Journal of pharmacological sciences. 2023. 151. 1. 37-45
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Chisato Kinoshita, Noriko Kubota, Koji Aoyama. Glutathione Depletion and MicroRNA Dysregulation in Multiple System Atrophy: A Review. International journal of molecular sciences. 2022. 23. 23. 15076
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Chisato Kinoshita, Noriko Kubota, Koji Aoyama. Interplay of RNA-Binding Proteins and microRNAs in Neurodegenerative Diseases. International Journal of Molecular Sciences. 2021. 22. 10. 5292
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Chisato Kinoshita, Koji Aoyama. The Role of Non-Coding RNAs in the Neuroprotective Effects of Glutathione. International Journal of Molecular Sciences. 2021. 22. 8. 4245-4245
more... MISC (20): -
Matsumura Nobuko, Kinoshita Chisato, Nakaki Toshio, Aoyama Koji. The development of miR-96-5p gene knock out technique by CRISPR/Cas9 system. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 0. 3-P1-37
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Kinoshita Chisato, Matsumura Nobuko, Aoyama Koji, Nakaki Toshio. Increased glutathione via NOVA1 by administration of an inhibitor of the microRNA miR-96-5p. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2021. 94. 0. 1-P1-34
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松村暢子, 木下千智, 青山晃治. Mechanism of glutathione production in neurons. 日本薬理学雑誌. 2021. 156. 1. 26-30
- Kinoshita Chisato, Kikuchi-Utsumi Kazue, Matsumura Nobuko, Nakaki Toshio, Aoyama Koji. Increased GTRAP3-18 expression by miR-96-5p is mediated by a RNA-binding protein. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2020. 93. 0. 2-P-185
- 木下千智, 中木敏夫, 青山晃治. 日内リズムを呈するmicroRNAによる神経グルタチオンの制御メカニズム. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
more... Patents (3): -
miR-96-5pインヒビターとそれを含有する医薬組成物
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miR-96-5p inhibitor and a screening method for the inhibitor
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miR-96-5p阻害剤とそのスクリーニング法
Books (2): - Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease 6th Edition
Academic Press 2020
- The dopamine receptors
Humana Press 2010 ISBN:9781603273329
Lectures and oral presentations (17): -
The neuroprotective effect of a miR-96-5p inhibitor delivery to brain via the blood-brain barrier
(Neurological Disorders Summit 2023 2023)
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Targeted Delivery of MicroRNA-96-5p Inhibitor in the Mouse Brain Using Microbubbles and Ultrasound Technology Enhances Neuroprotection via Increasing Glutathione Levels
(RNA Therapeutics: From Concept to Clinic 2023)
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The effect of a miR-96-5p inhibitor delivery to brain using microbubbles and ultrasound technology on neuroprotection and autophagy activation.
(Japan Basic and Clinical Pharmacology Week 2022 2022)
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The neuroprotective effect of a miR-96-5p inhibitor delivery to brain using microbubbles and ultrasound technology.
(14th International Conference on Dementia, Alzheimer and Related Diseases 2022)
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The effect of a miR-96-5p inhibitor delivery to brain using microbubbles and ultrasound technology on neuroprotection and microglial activation
(The 95th Annual Meeting of the Japanese Pharmacological Society 2022)
more... Education (3): - 2004 - 2007 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Department of Biomolecular Engineering
- 2002 - 2004 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Department of Biomolecular Engineering
- 1998 - 2002 Tokyo Institute of Technology School of Bioscience and Biotechnology
Professional career (1): Work history (3): - 2023/04 - 現在 Teikyo University School of Medicine Department of Pharmacology associate professor/lecturer
- 2009/06 - 2023/03 Teikyo University School of Medicine Department of Pharmacology Assistant Professor
- 2007/04 - 2009/05 University of California, Irvine Postdoctoral Researcher
Association Membership(s) (2):
THE JAPANESE PHARMACOLOGICAL SOCIETY
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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