Research theme for competitive and other funds (16)：
2024 - 2027 Assessing the risk of lung cancer development and malignant transformation caused by PM2.5, as well as elucidating its mechanism of action
2024 - 2026 インフルエンザ感染におけるM細胞の誘導機構と感染病態における役割の解明
2023 - 2026 インフルエンザ感染におけるM細胞の誘導機構と感染病態における役割の解明
2019 - 2022 Elucidation of differentiation and function of M cell in the airway
2019 - 2022 呼吸器M細胞による外因性微粒子取り込み機構とその生物学的意義の解明
2016 - 2019 Effects of cellular mechanical environment on response to interleukin-1beta stimulation in isolated tenocytes
2016 - 2019 Molecular mechanisms underlying differentiation of intestinal M cells
2015 - 2019 Roles of a novel key regulatory molecule, USP2, in energy homeostasis
2016 - 2018 腸管特殊上皮M細胞成熟過程における転写制御機構の解析
2013 - 2016 Host-microbe interaction mediated by intestinal M cells
2013 - 2016 Visualization of the entire differentiation process of murine M cells: suppression of their maturation in cecal patches.
2012 - 2015 Modulatory effects of macrophage M-mod/USP2 on type2 diabetes
2012 - 2015 The possibility of M-cell differentiation regulated by novel intercellular communication system
2011 - 2012 Study on the interaction between M cells and immune cells in Peyer' spatch.
2008 - 2012 Regulation of mucosal immune system by polarized sorting in epithelial cells
2009 - 2010 Visualization and molecular analysis of antigen-uptake and -delivery at M cell.
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Papers (62)：
Ryohtaroh Matsumoto, Kosuke Ogata, Daisuke Takahashi, Yusuke Kinashi, Takahiro Yamada, Ryo Morita, Keisuke Tanaka, Kouya Hattori, Mayumi Endo, Yumiko Fujimura, et al. AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine. Cellular and Molecular Life Sciences. 2024. 81. 1
Yusuke Kinashi, Keisuke Tanaka, Shunsuke Kimura, Masato Hirota, Seiga Komiyama, Tomoko Shindo, Akinori Hashiguchi, Daisuke Takahashi, Shinsuke Shibata, Shin-Ichiro Karaki, et al. Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice. EBioMedicine. 2024. 106. 105256-105256
Hiroaki Shiratori, Kisara M Hattori, Kazuaki Nakata, Takuma Okawa, Seiga Komiyama, Yusuke Kinashi, Yuma Kabumoto, Yuria Kaneko, Motoyoshi Nagai, Tomoko Shindo, et al. Purified diet affects intestinal epithelial proliferation and barrier functions through gut microbial alterations. International immunology. 2024
Kouhei Koshida, Mitsuki Ito, Kyosuke Yakabe, Yoshimitsu Takahashi, Yuki Tai, Ryouhei Akasako, Tatsuki Kimizuka, Shunsuke Takano, Natsumi Sakamoto, Kei Haniuda, et al. Dysfunction of Foxp3+ Regulatory T Cells Induces Dysbiosis of Gut Microbiota via Aberrant Binding of Immunoglobulins to Microbes in the Intestinal Lumen. International journal of molecular sciences. 2023. 24. 10
Barutta F, Bellini S, Kimura S, Hase K, Corbetta B, Corbelli A, Fiordaliso F, Bruno S, Biancone L, Barreca A, et al. Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy. Autophagy. 2023. 19. 2. 505-524
Sox8 is essential for the production of antigen-specific S-IgA during the weaning period by regulating M-cell maturation. Clinical immunology & allergology. 2020. 73. 1. 89-95
Molecular mechanisms of plasma membrane deformation by M-Sec during TNT formation
(GSK meeting Tunneling Nanotubes (TNTs) - Cell-to-Cell Social Networking in Disease Conference 2016)
