HOMMA Hidenori

ホンマヒデノリ | HOMMA Hidenori

Affiliation and department：
Job title： Project associate professor

Research field (3)： Intelligent informatics , Neuroscience - general , Mathematical informatics

Research theme for competitive and other funds (1)：

Papers (35)：

Yuki Yoshioka, Yong Huang, Xiaocen Jin, Kien Xuan Ngo, Tomohiro Kumaki, Meihua Jin, Saori Toyoda, Sumire Takayama, Maiko Inotsume, Kyota Fujita, et al. PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation. The EMBO journal. 2024
Hidenori Homma, Kien Xuan Ngo, Yuki Yoshioka, Hikari Tanaka, Maiko Inotsume, Kyota Fujita, Toshio Ando, Hitoshi Okazawa. PQBP3/NOL7 is an intrinsically disordered protein. Biochemical and biophysical research communications. 2024. 736. 150453-150453
Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Shinichi Shirai, Yuka Hama, Hajime Komano, Yuko Saito, Ichiro Yabe, Hideyuki Okano, Hidenao Sasaki, et al. Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Communications biology. 2024. 7. 1. 413-413
Hidenori Homma, Hikari Tanaka, Kyota Fujita, Hitoshi Okazawa. Necrosis Links Neurodegeneration and Neuroinflammation in Neurodegenerative Disease. International journal of molecular sciences. 2024. 25. 7
Yuki Yoshioka, Juliana Bosso Taniguchi, Hidenori Homma, Takuya Tamura, Kyota Fujita, Maiko Inotsume, Kazuhiko Tagawa, Kazuharu Misawa, Naomichi Matsumoto, Masanori Nakagawa, et al. AAV-mediated editing of PMP22 rescues Charcot-Marie-Tooth disease type 1A features in patient-derived iPS Schwann cells. Communications medicine. 2023. 3. 1. 170-170

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MISC (24)：

田中ひかり, 金美花, 塩飽裕紀, 吉岡優希, 金キョウシン, 近藤和, 藤田慶大, 本間秀典, 岡澤均. 脳炎症における知的障害原因遺伝子PQBP1の役割. Dementia Japan. 2022. 36. 4. 750-750
本間秀典, Jin Meihua, Jin Xiaocen, 藤田慶大, 田中ひかり, 田川一彦, 岡澤均. 動的分子ネットワーク解析法に基づくAD-FTLD間の共通病態ネットワーク予測. Dementia Japan. 2022. 36. 4. 761-761
藤田慶大, 本間秀典, 田中ひかり, Jin Meihua, Jin Xiaocen, Huang Yong, 吉岡優希, 近藤和, 塩飽裕紀, 田川一彦, et al. 胎児期神経幹細胞のDNA損傷が早期神経細胞ネクローシスを介してFTLD発症を運命付ける. Dementia Japan. 2021. 35. 4. 609-609
田中ひかり, 本間秀典, 藤田慶大, 近藤和, Jin Xiaocen, 田川一彦, 岡澤均. YAP依存的ネクローシスは超早期アルツハイマー病態を制御する. Dementia Japan. 2020. 34. 4. 473-473
田中ひかり, 近藤和, 陳西貴, 本間秀典, 田川一彦, 藤田慶大, 岡澤均. 発達障害原因遺伝子PQBP1はアルツハイマー病態を制御する. Dementia Japan. 2020. 34. 4. 527-527

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Lectures and oral presentations (51)：

HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology
(NEURO2022 2022)
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation
(NEURO2022 2022)
DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis
(63rd Annual Meeting of the Japanese Society of Neurology 2022)
Effect of YAP-dependent necrosis in the ultra early stage on Alzheimer's disease pathology
(63rd Annual Meeting of the Japanese Society of Neurology 2022)
動的分子ネットワーク解析を用いたFTLD-AD間における共通コア病態の予測
(第13回 CBIR/ONSA/大学院セミナー共催若手インスパイアシンポジウム 2021)

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Education (2)：

2004 - 2009 University of Tsukuba Graduate School of Systems and Information Engineering
2000 - 2004 University of Tsukuba

Professional career (1)：

Work history (8)：

2024/10 - 現在 Institute of Science Tokyo Department of Neuropathology Project associate professor
2022/04 - 2024/09 Tokyo Medical and Dental University Department of Neuropathology, Medical Research Institute project associate professor
2021/06 - 2022/03 Tokyo Medical and Dental University Department of Neuropathology, Medical Research Institute Specially appointed lecturer
2013/04 - 2021/05 Tokyo Medical and Dental University Department of Neuropathology, Medical Research Institute
2012/08 - 2013/03 Mie University Faculty of Engineering Department of Information Engineering

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