Research theme for competitive and other funds (19)：
2022 - 2025 共有結合DNAアプタマーと増殖型レトロウイルスを応用した膵癌免疫療法の開発
2022 - 2025 Genomic instability and immunology of hepato-biliary cancer
2021 - 2024 CA19-9を標的とした共有結合DNAアプタマーによる膵癌新規治療法の開発
2020 - 2023 Research on the mutual paracrine effect by MMP-9 and sCD154 between CD40 positive ESCC cells and platelets
2020 - 2023 ゲノム・遺伝子変異プロファイル解析を用いた膵癌における新規治療戦略の構築
2019 - 2022 Development of retroviral replicating vector-mediated prodrug activator gene therapy for biliary tract cancer
2018 - 2021 Retroviral replicating vector-mediated gene therapy for lung cancer
2018 - 2021 Development of a new therapeutic method for pancreatic cancer using a cell-penetrating peptide targeting C16orf74
2018 - 2021 Multi-omics analysis for hepato-biliary-pancreatic cancers
2018 - 2021 Retroviral replicating vector mediated gene therapy activates anti-tumor immune responses in an immunocompetent pancreatic cancer model
2017 - 2020 Development of immunotherapy following curative resection for refractory solid cancers
2016 - 2019 Discovering the biomarkers and development of new therapeutics in pancreatic cancer
2015 - 2018 Near infrared fluorescence light imaging for para-aortic lymph node targeting in hepatobiliary malignancies
2014 - 2017 Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice
2014 - 2017 Retroviral Replicating Vector (RRV)- Mediated Prodrug-Activator Gene Therapy for Pancreatic Cancer
2014 - 2017 Treatment strategy to prevent postoperative recurrence of cancers by inducing host immune responses following neoadjuvant chemotherapy.
2013 - 2016 The cell permeable peptide inhibits pancreatic ductal adenocarcinoma cell proliferations and can be used as the molecular targeting dru
2011 - 2012 The analysis of the mechanism to induce the tumor specific immune responses by the anti-cancer agents and its clinical utilization
2010 - 2012 Identification of the marker for cholangiocarcinoma based on the data by proteomics and tissue microarray
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Papers (547)：
Hao Zhang, Takahiro Tsuchikawa, Satoshi Takeuchi, Kenji Hirata, Kimitaka Tanaka, Aya Matsui, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Toru Nakamura, et al. Initial validation of the clinical significance of the NETest in Japanese gastroenteropancreatic neuroendocrine tumor patients. Endocrine journal. 2024. 71. 9. 873-880
Hiroki Niwa, Toru Nakamura, Hiroki Kushiya, Tomotaka Kuraya, Kazuho Inoko, Akihito Inagaki, Tomohiro Suzuki, Katsunori Sasaki, Takahiro Tsuchikawa, Kei Hiraoka, et al. Therapeutic activity of retroviral replicating vector-mediated gene therapy in combination with anti-PD-1 antibody in a murine pancreatic cancer model. Cancer gene therapy. 2024. 31. 9. 1390-1401
Hao Zhang, Takahiro Tsuchikawa, Satoshi Takeuchi, Hang Deng, Kimitaka Tanaka, Aya Matsui, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Toru Nakamura, et al. Distinct clinicopathological features of neuroendocrine liver metastases originating from the pancreas and rectum. World journal of surgical oncology. 2024. 22. 1. 209-209
