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J-GLOBAL ID：201301093635778260   Update date: Feb. 20, 2025

Kuroki Kimiko

クロキ キミコ | Kuroki Kimiko
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Affiliation and department：
北海道大学 大学院薬学研究院 創薬科学部門

About 北海道大学 大学院薬学研究院 創薬科学部門


Job title： 准教授
Homepage URL  (1)： http://kaken.nii.ac.jp/d/r/90553313.ja.html
Research field  (7)： Genomics ,  Pharmaceuticals - analytical and physicochemistry ,  Immunology ,  Medical biochemistry ,  Biophysics ,  Functional biochemistry ,  Structural biochemistry
Research keywords  (16)： ウイルスペプチド ,  抗体医薬品 ,  構造解析 ,  分子免疫学 ,  バイオ医薬品 ,  遺伝子多型産物 ,  HIV Nef ,  HIV-2 ,  免疫チェックポイント ,  LILR ,  KIR ,  免疫制御 ,  HLA ,  表面プラズモン共鳴法 ,  細胞表面受容体 ,  蛋白質間相互作用
Research theme for competitive and other funds  (8)：
  • 2022 - 2025 免疫抑制分子HLA-Gアイソフォームを特異的に機能阻害する腫瘍治療抗体医薬品開発
  • 2018 - 2021 Molecular recognition of immune inhibitory receptor, LILRB2, with HLA-G2 and various ligands
  • 2013 - 2015 強直性脊椎炎病因蛋白質HLA-B27の受容体LILRB2を介した発症機構の解明
  • 2013 - 2015 Structural analysis of HLA-G6 isoform bound to LILRB2 receptor
  • 2011 - 2013 強直性脊椎炎病因蛋白質HLA-B27ホモ二量体の立体構造解析
Show all
Papers (72)：
  • Yiwei Liu, Takahiro Mori, Yusei Ito, Kimiko Kuroki, Seiichiro Hayashi, Daisuke Kohda, Taro Shimizu, Tatsuhiro Ishida, Steve R Roffler, Mika K Kaneko, et al. The strategy used by naïve anti-PEG antibodies to capture flexible and featureless PEG chains. Journal of controlled release : official journal of the Controlled Release Society. 2025. 380. 396-403
  • Chisato Yamada, Kimiko Kuroki, Naoyoshi Maeda, Hiroshi Watanabe, Ami Takahashi, Katsumi Maenaka. Enhanced effect of the immunosuppressive soluble HLA-G2 homodimer by site-specific PEGylation. Scientific reports. 2025. 15. 1. 2509-2509
  • Hideo Fukuhara, Kohei Yumoto, Miyuki Sako, Mizuho Kajikawa, Toyoyuki Ose, Mihiro Kawamura, Mei Yoda, Surui Chen, Yuri Ito, Shin Takeda, et al. Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination. eLife. 2024. 12
  • Takayuki Chikata, Wayne Paes, Nozomi Kuse, Thomas Partridge, Hiroyuki Gatanaga, Yu Zhang, Kimiko Kuroki, Katsumi Maenaka, Nicola Ternette, Shinichi Oka, et al. Impact of Micropolymorphism Outside the Peptide Binding Groove in the Clinically Relevant Allele HLA-C*14 on T Cell Responses in HIV-1 Infection. Journal of virology. 2022. 96. 10. e0043222
  • Kimiko Kuroki, Hideo Fukuhara, Takashi Tadokoro, Katsumi Maenaka. Low-Cost Cell-Surface-Mimic Analysis of Ligand Interactions of Biotinylated Immune Receptors Using Surface Plasmon Resonance. Methods in molecular biology (Clifton, N.J.). 2022. 2421. 21-35
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MISC (136)：
  • 露木貴浩, POZA Pablo Adrian Guillen, 加藤いづみ, 喜多俊介, 黒木喜美子, 前仲勝実, 前田直良, 前田直良. X-ray crystallography of novel anti-proliferative monoclonal antibody against adult T-cell leukemia cells. 日本薬学会年会要旨集(Web). 2024. 144th
  • 古関亮太, 小澤偉大, 平尾憲吾, 田所高志, 鷲見正人, ANDREWS Sophie, SARAH Rowland-Jones, 黒木喜美子, 前仲勝実. Binding analysis of HIV-2 Nef protein with host CD3 intracellular motif. 日本薬学会年会要旨集(Web). 2024. 144th
  • 下柿元咲瑛, 黒木喜美子, 引地和馬, 赤岩愛記, 古川敦, 古川敦, 前田直良, 前仲勝実. Screening of original HLA-G antibodies for induction of tumor immunity. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 黒木 喜美子. 【免疫系多重遺伝子ファミリー多様性と疾患】免疫系多重遺伝子ファミリー分子LILRBの構造解析と疾患. 炎症と免疫. 2022. 30. 5. 390-393
  • 渡邊 紘士, 黒木 喜美子, 前仲 勝実. 免疫抑制性タンパク質HLA-G2の新規受容体探索と結合親和性評価. 日本薬学会年会要旨集. 2022. 142年会. 26L-pm03S
ｍore...
Patents (11)：
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Education (2)：
  • - 2004 The University of Tokyo Graduate School of Medicine International Health
  • - 1999 Tokyo University of Science Faculty of Science and Technology Applied Biological Science
Professional career (1)：
  • 博士(保健学) (東京大学大学院)
Work history (7)：
  • 2024/04 - 現在 Hokkaido University Faculty of Pharmaceutical Sciences
  • 2018/04 - 現在 北海道大学薬学研究院
  • 2010/07 - 2018/03 Hokkaido University Faculty of Pharmaceutical Sciences
  • 2010/04 - 2010/06 Hokkaido University Faculty of Pharmaceutical Sciences
  • 2008/04 - 2010/03 Kyushu University Medical Institute of Bioregulation
Show all
Association Membership(s) (6)：
JAPANESE SOCIETY FOR HISTOCOMPATIBILITY AND IMMUNOGENETICS ,  THE JAPANESE SOCIETY FOR IMMUNOLOGY ,  JAPAN COLLEGE OF RHEUMATOLOGY ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE PHARMACEUTICAL SOCIETY OF JAPAN
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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