Rchr
J-GLOBAL ID:201401001067568642   Update date: Sep. 28, 2024

Harada Hiroshi

ハラダ ヒロシ | Harada Hiroshi
Affiliation and department:
Research field  (6): Molecular biology ,  Cell biology ,  Pathobiochemistry ,  Radiology ,  Genomics ,  Tumor biology
Research theme for competitive and other funds  (32):
  • 2023 - 2026 放射線抵抗性の腫瘍内低酸素分画をモニターする血中バイオマーカーの開発
  • 2021 - 2026 Assessment of the relationship between the dynamics of tumor hypoxia areas and hypoxia inducible factor in radiotherapy for pancreatic cancer
  • 2022 - 2025 Plasma biomarkers for "early detection" and "prognosis prediction" of cancer using intratumoral hypoxia as an indicator
  • 2020 - 2025 Formation of an international research center for integrated radiation science targeting complex systems in living organisms
  • 2019 - 2025 老化リボソームの実体解明と機能強化による健康寿命の延長
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Papers (169):
  • Gouki Kambe, Minoru Kobayashi, Hiroshi Ishikita, Sho Koyasu, Ester M. Hammond, Hiroshi Harada. ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1. Biochemical and Biophysical Research Communications. 2024. 733. 150604-150604
  • Huiying Mu, Shuai Shao, Bingquan Wu, Koji Miki, Minoru Kobayashi, Hiroshi Harada, Kouichi Ohe. Fast tumor imaging using pH-responsive aggregation of cyanine dyes with rapid clearance. Sensors and Actuators B: Chemical. 2024. 413. 135876-135876
  • Iori Tamura, Daichi M. Sakamoto, Bo Yi, Yutaro Saito, Naoki Yamada, Jumpei Morimoto, Yoichi Takakusagi, Masafumi Kuroda, Shimpei I. Kubota, Hiroyuki Yatabe, et al. Click3D: Click reaction across deep tissues for whole-organ 3D fluorescence imaging. Science Advances. 2024. 10. 29
  • Shogo Iseki, Hiroaki Ikeda, Sayaka Kobayashi, Kazuhiro Irie, Hiroshi Harada, Hideaki Kakeya. Teleocidin B-4, a PKC Activator, Upregulates Hypoxia-Inducible Factor 1 (HIF-1) Activity by Promoting the Accumulation of HIF-1α Protein via the PKCα/mTORC Signaling Pathway. Journal of Natural Products. 2024. 87. 6. 1666-1671
  • 原田浩, 三浦雅彦, 稲波修. 生物部会からの提言:増殖死と分裂死の定義について. 放射線生物研究. 2024. 59. 2. 165-171
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MISC (24):
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Patents (9):
  • 低酸素バイオマーカー及びその利用
  • 低酸素バイオマーカー及びその利用
  • がんを治療するための医薬組成物
  • がんを治療するための医薬組成物
  • 新規抗腫瘍剤及び新規抗腫瘍剤のスクリーニング方法
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Books (5):
  • 放射線治療学 改訂7版
    南山堂 2023 ISBN:9784525270971
  • がん・放射線療法 改訂第8版
    2023
  • Molecularly based Chemoradiotherapy and High-Precision Radiotherapy. Tan D, Lynch H (eds).
    Lippincott Williams & Milkins. 2012
  • Protein Transduction Domain-mediated Delivery of Anti-cancer Drugs and Proteins. Lu Y and Mahato RI (eds). Pharmaceutical Perspectives of Cancer Therapeutics.
    Springer 2009
  • Combination of Antimetabolites and Ionizing Radiation. Medical Radiology: Radiation Oncology, Multimodal Concepts for Integration of Cytotoxic Drugs.
    Springer 2006
Lectures and oral presentations  (163):
  • 低酸素刺激によるがんのクローン進化
    (第28回癌治療増感研究会 2024)
  • ZBTB2はp53変異型がん細胞の悪性形質をHIF-1依存的に誘導する
    (第28回日本がん分子標的治療学会学術集会 2024)
  • 酸素生物学で迫るがんの素顔
    (信濃町Feather研究会 2024)
  • 腫瘍組織内の低酸素とは
    (第1回統合放射線科学リトリート 2024)
  • がんと放射線: 研究の深化と治療法の進化
    (桃山オープンセミナー 2024)
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Professional career (1):
  • 博士(理学) (名古屋大学)
Awards (13):
  • 2023/11 - The Japanese Radiation Research Society JRRS Distinguished Scientist Award
  • 2023/06 - Osaka Neuclear Science Association ONSA Award
  • 2022/12 - Japanese Society for Radiation Oncoglogy Abe Award
  • 2018/11 - Journal of Radiation Research JRR Terasima Award Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance
  • 2014/10 - 日本放射線腫瘍学会 第12回優秀教育講演賞 放射線腫瘍学における"がん幹細胞"と"低酸素"
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