Ono Yuko

• 2024 - 2027 Elucidation of the pathophysiology of skeletal muscle atrophy in aged patients with sepsis and myokine for the novel therapeutic target of post intensive care syndrome (PICS)
• 2022 - 2025 JAK-STAT3 signaling pathway inhibition for burn-induced skeletal muscle atrophy
• 2022 - 2023 Gender disparities in first authorship at three medical universities in an area affected by the Great East Japan Earthquake
• 2021 - 2022 Toll like receptor/Nuclear Factor-kappa B signaling pathway inhibition for burn-induced skeletal muscle atrophy
• 2018 - 2022 Nuclear Factor-kappa B Signaling Inhibition for Sepsis-induced Skeletal Muscle Atrophy
2018 - 2019 Drug Exploration for Sepsis-Induced Skeletal Muscle Atrophy
2015 - 2018 Identification of the mechanism of sepsis induced muscle wasting and potential pharmacological treatment

• Yuko Ono, Tasuku Uzawa, Jun Sugiyama, Nozomi Tomita, Takeyasu Kakamu, Tokiya Ishida, Joji Kotani, Kazuaki Shinohara. Comparison of survival outcomes and anatomically specific severe injuries following traffic accidents among occupants of standard and K-car vehicles: A retrospective cohort study at a teaching hospital in Japan. PLOS ONE. 2025. 20. 2. e0318748-e0318748
• Yoshihisa Fujinami, Masafumi Saito, Yuko Ono, Masaya Akashi, Shigeaki Inoue, Joji Kotani. Malocclusion Worsens Survival Following Sepsis Due to the Disruption of Innate and Acquired Immunity. International Journal of Molecular Sciences. 2025. 26. 5. 1894
• Chan M, Ono Y, Yamada I, Kotani J. Intravascular lymphoma presenting with systemic inflammatory response syndrome ad multiple organ failure that mimicking sepsis: A case report (in Japanese). The Japanese journal of acute medicine. 2024. 48. 8. 1003-1010
• Masafumi Saito, Naoki Moriyama, Yuko Ono, Joji Kotani. What do increased-T cells do in the brain after sepsis?. The Cell (in Japanese). 2024. 56. 8. 613-617
• Yuko Ono, Kauzaki Shinohara, Tokiya Ishida, Isamu Yamada, Joji Kotani. Migration of a pericardial drainage catheter into the right main pulmonary artery. Acute Medicine & Surgery. 2024. 11. 1. e968-e968

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• Yuko Ono. Crush syndrome. Kusnoki communication. vol. 94 Health notebook No. 90. 2024. 94
• Yuko Ono. Nuclear Factor-kappa B Signaling Inhibition for Sepsis-induced Skeletal Muscle Atrophy. an accomplishment report. JSPS KAKENHI Grant Number 18K16544. 2023
• 藤浪好寿, 斎藤雅史, 大野雄康, 岡崎智哉, 篠原奈都代, 一二三亨, 黒田泰弘, 大山正平, 藤岡一路, 山田勇, et al. 重症患者における咬合不全のインパクトを探る. 日本臨床栄養代謝学会学術集会(Web). 2023. 38th
• 杉山隼, 杉山隼, 井上茂亮, 高山和之, 中西信人, 藤浪好寿, 齋藤雅史, 大野雄康, 小谷穣治. COVID-19感染拡大期における搬送先での医療廃棄物処理システムが救急隊業務効率と院外心肺停止患者予後へ与える影響. 日本病院前救急診療医学会誌. 2023. 18. 1
• 齋藤雅史, 齋藤雅史, 大野雄康, 中西信人, 小谷穣治. 頸部リンパ節を除去した敗血症マウスでは,脳へのT細胞の浸潤が抑制され,敗血症に伴う精神障害の回復が遅れる. 日本エンドトキシン・自然免疫研究会プログラム・抄録集. 2023. 28th

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• How to manage the patients with anaphylaxis in the emergency departments? In: Kondo Y, editor. Chugaiigaku. Co, Tokyo, Japan.
  Chugaiigaku. Co, Tokyo, Japan. 2023 ISBN:9784498166646
• Prevention and early interventions of PICS.
  Japan Medical Journal. Co, Tokyo, Japan 2022 ISBN:9784784959716
• Principal Emergency drugs for residents and nurses. Neuromuscular blocking agents. In: Ono Y, Joji K. Emer-Log. Vol 34 No.5.
  MEDICUS SHUPPAN, Publishers Co., Ltd. Osaka, Japan. 2021
• In: Nishida O, Joji K, and Inoue S. All about PICS: Q&A 40.
  Chugaiigaku. Co, Tokyo, Japan 2020 ISBN:9784498166202
• In: Asai T, Ueshima H. Airway management case files for emergency lifesaving technicians
  Chugaiigaku.Co, Tokyo, Japan. 2019

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• Let's learn the basic research methods: Basical research in critical care. symposium.
  (The 52nd Annual meeting of the Japanese Society of Intensive Care Medicine. Fukuoka, Japan. 2025)
• The molecular mechanism of ICU-acquired weakness
  (The 51st Annual meeting of the Japanese Society of Intensive Care Medicine 2024)
• The molecular mechanism of ICU-acquired weakness. symposium 12. Inflammation and organ dysfunction: the frontier in basic research.
  (The 51st Annual meeting of the Japanese Society of Intensive Care Medicine, Sapporo, Japan. 2024)
• Oncostatin M is associated with sepsis induced skeletal muscle atrophy and sepsis severity
  (The 28th Annual meeting of the Japanese Endotoxin and Innate Immunity Society 2023)
• IL6/STAT3 signaling as a therapeutic target for the thermal burn-induced skeletal muscle atrophy
  (The highlight session 11. The 51st Annual Meeting of the Japanese Association for Acute Medicine 2023)

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• 2022/04 - 現在 Hyogo Prefectural Tamba Medical Center, Tamba, Hygo, Japan. Department of emergency medicine Part-time Physician
• 2020/06 - 現在 Kobe University Department of Disaster and Emergency Medicine, Graduate School of Medicine. Assistant Professor
• 2018/04/01 - 現在 Postdoctoral Researcher, Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University
• 2019/04 - 2022/03 Hyogo Prefectural Awaji Medical Center, Sumoto, Hyogo, Japan Emergency and Critical Care Medical Center Part-time Physician
• 2020/04 - 2020/05 Kobe University Graduate School of Medicine, Department of Disaster and Emergency Medicine, Kobe, Japan. Specially Appointed Assistant Professor
2019/04 - 2020/03 Kobe University Department of Disaster and Emergency Medicine, Graduate School of Medicine Attending physician
2018/06 - 2019/03 Fukushima Medical University Hospital,Emergency and Critical Care Medicine, Assistant Professor
2014/04 - 2019/03 Ohta General Hospital Foundation, Ohta Nishinouchi Hospital Department of Anesthesiology Part-time Physician
2014/04 - 2018/05 Fukushima Medical University Hospital,Emergency and Critical Care Medicine, Assistant Professor
2013/10/01 - 2018/03/31 Department of Pharmacology, Fukushima Medical University Graduate school student and teaching assistant
2012/04/01 - 2014/03/31 Ohta General Hospital Foundation, Ohta Nishinouchi Hospital,Department of Anesthesiology, Attending anesthesiologist
2010/04/01 - 2012/03/31 Fukushima Medical University Hospital,Emergency and Critical Care Medicine, Senior Resident
2010/04 - 2012/03 Shodokai Southern Tohoku Hospital, Iwanuma, Miyagi, Japan Department of Anesthesiology Part-time Physician
2009/11 - 2010/03 Shodokai Southern Tohoku Hospital Department of Anesthesiology Attending physician
2009/04/01 - 2009/10/31 Fukushima Medical University Hospital,Emergency and Critical Care Medicine, Senior Resident
2007/04/01 - 2009/03/31 Fukushima Medical University Hospital, Junior Resident

• 2024/04 - 現在 The Japan Shock Society Councilor
• 2024/04 - 現在 Kobe University, Kobe, Japan Clinical study management committee, clinical study manager
• 2024/02 - 現在 The Japanese Society of Intensive Care Medicine The 52nd annual meeting of the Japanese Society of Intensive Care Medicine, Academic program committee
• 2023/08 - 現在 Kobe University, Kobe, Japan Clinical laboratory Department Liaison Committee
• 2023/04 - 現在 Hanshin Tamba region, medical control council Hanshin Tamba region, medical control council, Post-verification committee
2023/04 - 現在 Kobe city medical control council Kobe city medical control council training committee
2023/01 - 現在 Japanese Association for Acute Medicine Technical terminology committees
2021/04 - 現在 Kobe University, Kobe, Japan. CVC hands-on seminar working group
2020/04 - 現在 Kobe University, Kobe, Japan Kusunoki district internet network committee
2020/04 - 現在 Kobe University, Kobe, Japan. Diagnosis Procedure Combination (DPC) coding Committee
2020/04 - 現在 Kobe University, Kobe, Japan Insurance Committee
2020/04 - 現在 Kobe University, Kobe, Japan Operating Room Liaison Committee
2025/03 - 2025/03 Kobe University, Kobe, Japan Common achievement tests examination question preparation committee, Member Create 1 examination question (Anaphylaxis/anaphylaxis shock)
2022/04 - 2025/03 Japan Endotoxin and Innate Immunity Society Executive director
2024/03 - 2024/10 Special Issue Editors, Current Therapies for Trauma and Surgical Critical Care, A special issue of Medicina (ISSN 1648-9144):https://www.mdpi.com/journal/medicina/special_issues/Z29090RB1M Special Issue Editors
2024/07 - 2024/07 Kobe University, Kobe, Japan Graduate examination question preparation committee, Member. Create 10 examination questions
2023/08 - 2024/04 The 2nd annual meeting of the ERAS® Japan society Executive director
2023/11 - 2023/11 Frontiers in Education, section Educational Psychology Associate editor
2023/07 - 2023/07 Kobe University, Kobe, Japan Graduate examination question preparation committee, Member. Create 7examination questions
2022/07 - 2022/07 Kobe University, Kobe, Japan Graduate examination question preparation committee, Member. Create 3 examination questions
2021/10 - 2022/06 Kobe University, Kobe, Japan Employee education working group
2021/03 - 2021/03 Kobe University, Kobe, Japan Common achievement tests examination question preparation committee, Member Create 1 examination question (Cardiopulmonary resuscitation)
2020/08 - 2020/08 Kobe University, Kobe, Japan Graduate examination question preparation committee, Member Create 3 examination questions
2020/03 - 2020/03 Kobe University, Kobe, Japan Common achievement tests examination question preparation committee, Member
2019/10 - 2020/03 Kobe University, Kobe, Japan Disaster Preparedness Working Group, Member
2018/04 - 2019/03 Fukushima Medical University, Fukushima, Japan Supporting Staff, Office for Gender Equality Support
2016/04 - 2019/03 Fukushima Medical University, Fukushima, Japan Clinical Pathological Conference Committee, Committee member

• 2024/04 - Journal of Clinical Medicine Exceptional reviewer 2024
• 2023/11 - the Japanese Association for Acute Medicine The best scientific paper award of the Japanese Association for Acute Medicine The best-case report award Intravenous idarucizumab for dabigatran overdose: association between plasma dabigatran concentration and coagulation profile (in Japanese). JJAAM. 2023; 34: 6-11
• 2023/07 - The 29th annual conference on cytokine research in surgery and critical care The president's award Awarded presentation: Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Shigeaki Inoue, Joji Kotani. STAT3 signaling as a therapeutic target for the thermal burn-induced skeletal muscle wasting.
• 2023/06 - Kobe University The excellent young investigator award (2023)
• 2023/06 - The 70th Annual Meeting of the Japanese Society of Anesthesiologists, Kobe, Japan. Award for best presentation (Emergency medicine and ICU) C188-9, a specific inhibitor of STAT3 signaling, ameliorates thermal burn-induced skeletal muscle wasting in mice.
2021/10 - 16th Meeting of the International Endotoxin and Innate Immunity Society & 26th Japanese Endotoxin and Innate Immunity Society Award for outstanding presentation Thermal burn injury increases STAT3 signaling pathway activation, following to induce skeletal muscle atrophy in mice.
2021/07 - PLOS ONE The top 10% most cited PLOS ONE papers published in 2017 Awarded paper: Ono Y, Sakamoto K. Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-α. PLoS One. 2017;12:e0182040.
2021/03 - Scientific Reports The top 100 downloaded cell and molecular biology papers for Scientific Reports in 2020 Awarded paper: Ono Y, et al. TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice. Sci Rep. 2020;10:694.
2021/03 - Japanese Association for Medical Simulation Best paper award Ono Y, et al. Lower maximum forces on oral structures when using gum-elastic bougie than when using endotracheal tube and stylet during both direct and indirect laryngoscopy by novices: a crossover study using a high-fidelity simulator. BMC Emerg Med. 2020;20:34.
2020/02 - The 24th Annual Meeting of Japan Society of Critical Care for Endotoxemia Award for best presentation Lipopolysaccharide inhibits phosphorylation of Akt and S6k in mice skeletal muscle
2019/06 - The 66th Annual Meeting of the Japanese Society of Anesthesiologists Award for best presentation TAK-242, a specific inhibitor of Toll like receptor 4 signaling ameliorates sepsis induced muscle wasting in mice.
2017/06/08 - the Japanese Society of Anesthesiologists Excellent presentation session, The 64th Annual Meeting of the Japanese Society of Anesthesiologists Lipopolysaccharide Inhibits Myogenic Differentiation of C2C12 Myoblasts Through the Toll-like Receptor 4 Nuclear Factor-κB Signaling Pathway
2015/05 - The Japanese society of Anesthesiologists The 62nd Japanese society of Anesthesiologists, Excellent presentation session Emergency endotracheal intubation-related adverse events in bronchial asthma exacerbation: can anesthesiologists attenuate the risk?
2014/06 - The 23rd Annual Meeting of the Japanese Society of Intensive Care Medicine, Tohoku Branch Award for best presentation,The 23rd Annual Meeting of the Japanese Society of Intensive Care Medicine, Tohoku Branch Massive subcutaneous emphysema, bilateral pneumothorax, pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum, and pneumoscrotum after multiple direct laryngoscopies: an autopsy case report

Japan Endotoxin and Innate Immunity Society ,  Japan Society for Critical Care Medicine (No. CCM0476) ,  The Japan Shock Society (No. 1748) ,  Japanese Association for Medical Simulation (No. JAMS-0829) ,  Japanese Society of Intensive Care Medicine (No. 5431) ,  Japanese Society of Anesthesiologists (No. 00015541) ,  Japanese Association for Acute Medicine (No. o1702)