Rchr
J-GLOBAL ID：201401015864839458
Update date: Jun. 25, 2024
Iioka Hidekazu
イイオカ ヒデカズ | Iioka Hidekazu
Affiliation and department：
Job title：
associate professor
Homepage URL (1)：
http://kaken.nii.ac.jp/d/r/20425416.ja.html
Research field (4)：
Cell biology
, Molecular biology
, Tumor biology
, Experimental pathology
Research keywords (3)：
cell polarity
, cell migration
, invasion and metastasis
Research theme for competitive and other funds (13)：
- 2023 - 2026 大腸腺癌転移におけるリン酸化Crumbs3の意義
- 2020 - 2023 ホーミングペプチドを基盤にした新規膵癌バイオマーカー及び膵癌標的化抗体医薬の開発
- 2020 - 2023 Crb3-PTPN3系を介した新規大腸腺癌転移制御機構の解析と転移阻害への応用
- 2021 - 2022 The identification of soluble proteins regulated by the metastasis promoter Crumbs3
- 2017 - 2020 Functional analyses of Crumbs3 as the moleculer switch of cell-matrix adhesion in colon cancer progression
- 2014 - 2016 Expression and functional analyses of Crb3a in tumor tissues
- 2014 - 2016 The analyses of regulatory mechanism of tubular formation and cell migration by cell polarity regulator Crb3
- 2013 - 2014 The analysis of cell polarity regulator in tumor development
- 2013 - 2013 The analyses of post-translational regulation and tumor suppressor activity of cell polarity regulator Crb3
- 2012 - 2013 The role of gene expression of the cell polarity regulator in tumor development
- 2012 - 2013 The functional analysis of the cell polarity regulator as a tumor suppressor
- 2009 - 2010 頂底極性決定因子CrumbsのmRNA局在化機構の解析
- 2007 - 2009 The analysis of gene expression regulation by beta-catenin pathway
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Papers (26)：
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Ayaka Mitsui, Hidekazu Iioka, Yiwei Ling, Shujiro Okuda, Akira Kurose, Michael Schopperle, Tomoko Kondo, Masakiyo Sakaguchi, Ken Saito, Eisaku Kondo. Pathological and biological significance of the specific glycan, TRA-1-60, on aggressive gastric adenocarcinoma. Laboratory Investigation. 2024. 102073-102073
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横山 侑輔, 飯岡 英和, 近藤 英作, 堀井 新. ヒト口腔扁平上皮癌におけるCrumbs3の発現と機能 浸潤転移における役割. 日本耳鼻咽喉科頭頸部外科学会会報. 2023. 126. 4. 656-656
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Yusuke Yokoyama, Hidekazu Iioka, Arata Horii, Eisaku Kondo. Crumbs3 is expressed in oral squamous cell carcinomas and promotes cell migration and proliferation by affecting RhoA activity. Oncology letters. 2022. 23. 6. 173-173
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Eisaku Kondo, Hidekazu Iioka, Ken Saito. Tumor-homing peptide and its utility for advanced cancer medicine. Cancer science. 2021. 112. 6. 2118-2125
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Yushi Ueki, Ken Saito, Hidekazu Iioka, Izumi Sakamoto, Yasuhiro Kanda, Masakiyo Sakaguchi, Arata Horii, Eisaku Kondo. PLOD2 Is Essential to Functional Activation of Integrin β1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas. iScience. 2020. 23. 2. 100850-100850
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MISC (2)：
Lectures and oral presentations (14)：
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口腔扁平上皮癌におけるCrumbs3の発現と機能の解析
(第25日本がん分子標的治療学会 2021)
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非受容体型脱リン酸化酵素PTPN3は、大腸腺癌の細胞移動を促進する
(第110回日本病理学会総会 2021)
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非受容体型脱リン酸化酵素PTPN3はCrumbs3と相互作用し、大腸腺癌の細胞移動を促進する
(第24日本がん分子標的治療学会 2020)
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新規Crumbs3結合タンパク質PTPN3は大腸腺癌の細胞移動を促進する
(第79回日本癌学会学術総会 2020)
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Crumbs3aは増殖因子容体の活性化を制御し大腸癌の進展を促進する
(第108回日本病理学会総会 2019)
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Education (3)：
- 2002 - 2005 The Graduate University for Advanced Studies School of Life Science
- 2000 - 2002 Gifu University
- 1996 - 2000 Kindai University Faculty of Agriculture
Professional career (1)：
- Ph.D (The Graduate University for Advanced Studies (SOKENDAI))
Work history (7)：
- 2024/04 - 現在 Niigata University of Pharmacy and Applied Life Sciences
- 2015/04 - 2024/03 Niigata University Graduate School of Medical and Dental Sciences Course for Molecular and Cellular Medicine
- 2012/05 - 2015/03 Aichi Medical University School of Medicine
- 2009/02 - 2012/04 バージニア大学 医学部 リサーチアソシエート
- 2009/04 - 2010/09 Japan Society for the Promotion of Science
- 2007/05 - 2009/01 ケースウェスタンリザーブ大学 医学部 リサーチスカラー
- 2005/04 - 2007/04 National Institute for Basic Biology
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Association Membership(s) (3)：
日本病理学会
, 日本癌学会
, 日本がん分子標的治療学会
