Rchr
J-GLOBAL ID:201401046466257794
Update date: Mar. 30, 2025 Hisashi Doi
ドイ ヒサシ | Hisashi Doi
Affiliation and department: Job title:
Specially Appointed Professor
Other affiliations (1): -
RIKEN
Center for Biosystems Dynamics Research, Laboratory for Chemical Biology
Visiting Scientist
Homepage URL (1): https://www.omu.ac.jp/orp/org/crc/drug_development/ Research field (3):
Pharmaceuticals - chemistry and drug development
, Synthetic organic chemistry
, Chemical reaction and process system engineering
Research keywords (10):
11C
, 18F
, 脳神経
, アミノ酸
, 生体分子
, 標識化学
, 合成化学
, 生物活性有機化合物
, 陽電子放射画像撮影法
, 分子プローブ
Research theme for competitive and other funds (11): - 2024 - 2027 末梢感染による脳内局所炎症が倦怠感を惹起する分子・神経基盤の解明
- 2024 - 2027 PETを用いた肝疾患病態におけるmRNA内封脂質ナノ粒子の動態-遺伝子発現相関研究
- 2020 - 2023 Development of SN-38 derivatives with antitumor activity toward theranostics
- 2015 - 2018 Construction of microcirculation and imaging evaluation method in intractable disease
- 2013 - 2016 Development of PET probes of neuroprotective molecular components in oriental medicines
- 2013 - 2016 Development of poorly water-soluble drug encapsulated protein nanocapsule possessing cancer directivity and application to DDS
- 2012 - 2015 Rh(I)-Mediated rapid [11C]carboxylation using [11C]CO2 and organoborane at atmospheric pressure
- 2012 - 2015 Design and synthesis of kainoid-type molecular probes for elucidation of the mechanism of allodynia induction
- 2008 - 2010 Synthesis of molecular probes for exploring the novel receptor involved in the allodynia induction
- 2007 - 2010 Synthesis of ^<18>F-labeled GABA, amino acids, and lactic acids by using oxazoline precursors
- 2000 - 2002 芳香環上へのポジトロン核種導入に向けた高速化学反応の開発と新規PETトレーサー合成
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Papers (126): -
Yumika Motooka, Ryota Shinohara, Shiho Kitaoka, Ai Uryu, Dongrui Li, Hiroyuki Neyama, Yilong Cui, Tatsuya Kida, Wakiko Arakaki, Hisashi Doi, et al. Alteration of COX-1 and TLR4 expression in the mouse brain during chronic social defeat stress revealed by Positron Emission Tomography study. Journal of pharmacological sciences. 2025. 157. 3. 156-166
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Ukihide Tateishi, Hisashi Doi. Transient receptor potential cation channel subfamily V member 1 (TRPV1) targeted PET imaging. Japanese Journal of Clinical Oncology. 2024
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Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, William Ewan Hume, Hisashi Doi, Yasuyoshi Watanabe. In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters. EJNMMI research. 2023. 13. 1. 36-36
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Tsuyoshi Tahara, Shuhei Takatani, Mieko Tsuji, Nina Shibata, Nami Hosaka, Michiko Inoue, Masahiro Ohno, Daiki Ozaki, Aya Mawatari, Yasuyoshi Watanabe, et al. Characteristic Evaluation of a 11C-Labeled Leucine Analog, l-α-[5-11C]methylleucine, as a Tracer for Brain Tumor Imaging by Positron Emission Tomography. Molecular pharmaceutics. 2023. 20. 3. 1842-1849
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Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, Nina Shibata, William E Hume, Emi Hayashinaka, Yasuhiro Wada, Hisashi Doi, Yasuyoshi Watanabe. Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response. Scientific reports. 2023. 13. 1. 1961-1961
more... MISC (29): -
越智祐太, 新垣和貴子, 胡迪, 李丹渓, 重田美香, 林中恵美, 和田康弘, 土居久志, 渡辺恭良, 崔翼龍. 擬似ウイルス感染モデルラットでの脳内炎症は倦怠感の惹起に関わる. 日本神経化学会大会抄録集(Web). 2022. 65th
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野崎 聡, 笹野 有未, 山本 憲一郎, 馬渡 彩, 柴田 仁奈, 中谷 友香, 尾上 嘉代, 和田 康弘, 露口 尚弘, 土居 久志, et al. バイオイメージングの創薬、診断、治療への展開 がんと炎症の差別化イメージング. 日本癌学会総会記事. 2017. 76回. S15-4
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馬渡 彩, 野崎 聡, 二宮 伸二, 渡辺 恭良, 土居 久志. チアミンおよびフルスルチアミンの11C-標識PETプローブの合成. ビタミン = Vitamins. 2017. 91. 3. 190-192
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坂本詩穂, 中辻匡俊, 中辻匡俊, 寺岡佳晃, 寺岡佳晃, 柘植祥吾, 清水翔太, 西野浩輔, 喜田達也, 土居久志, et al. 生体内輸送タンパク質を用いた新規SN-38誘導体の可溶化と抗腫瘍効果. 日本生化学会大会(Web). 2017. 90th
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西野浩輔, 喜田達也, 中辻匡俊, 清水翔太, 寺岡佳晃, 田村泰久, 久米慧嗣, 片岡洋祐, 乾隆, 土居久志. 抗腫瘍活性を持つ10-O-置換SN-38誘導体の開発と18F-標識体の合成. JSMI Report. 2016. 9. 2
more... Professional career (1): Work history (11): - 2023/04 - 現在 Osaka Metropolitan University Organization for Research Promotion, Collaborative Research Center, Research Institute for Drug Discovery Science Specially Appointed Professor
- 2023/04 - 2025/03 RIKEN Center for Biosystems Dynamics Research, Laboratory for Chemical Biology Visiting Scientist
- 2018/04 - 2023/03 RIKEN Center for Biosystems Dynamics Research, Laboratory for Labeling Chemistry Team Leader
- 2013/04 - 2018/03 RIKEN RIKEN Center for Life Science Technologies, Labeling Chemistry Team Team Leader
- 2009/04 - 2013/03 RIKEN Center for Molecular Imaging Science, Molecular Imaging Labeling Chemistry Team Team Leader
- 2008/10 - 2009/03 RIKEN Center for Molecular Imaging Science, Drug Synthesis & Molecular Probing Unit Unit Leader
- 2007/05 - 2008/09 RIKEN Molecular Imaging Research Program, Molecular Probe & Drug Design Laboratory Deputy Team Leader
- 2005/09 - 2007/04 RIKEN Molecular Imaging Research Program, Molecular Probe & Drug Design Laboratory Research Scientist
- 2005/04 - 2005/08 RIKEN RIKEN Molecular Imaging Research Program, Preparatory Office Member of Preparatory Office
- 2003/04 - 2005/03 Gifu University Graduate School of Medicine Technical Assistant
- 2000/04 - 2003/03 JSPS Research Fellow Nagoya University, Gifu University
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