Rchr
J-GLOBAL ID：201401049082985937   Update date: Nov. 18, 2024

Nakayama Kazuhisa

Nakayama Kazuhisa
Affiliation and department：
Kyoto University

About Kyoto University


Homepage URL  (1)： http://www.pharm.kyoto-u.ac.jp//physchem/
Research field  (1)： Cell biology
Research theme for competitive and other funds  (25)：
  • 2024 - 2027 繊毛内タンパク質輸送の異常に起因する繊毛病を分子から細胞分化のレベルで理解する
  • 2019 - 2024 Relationship between architecture and function of intraciliary protein trafficking complex: molecular basis for ciliopathies
  • 2020 - 2022 Architecture of the transition zone separating the cytoplasm and cilioplasmand, and selective protein translocation across it
  • 2015 - 2018 Regulation of vesicular trafficking by tethering complex and SNARE proteins
  • 2015 - 2017 タンパク質間相互作用解析とイメージングに基づく繊毛形成と繊毛内輸送機構の解明
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Papers (233)：
  • Tsukasa Yagi, Riki Nakabuchi, Yumeka Muranaka, Gaku Tanaka, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin. Lipid flippases ATP9A and ATP9B form a complex and contribute to the secretory pathway from the Golgi apparatus. 2024
  • Yumeka Muranaka, Ryo Shigetomi, Yugo Iwasaki, Asuka Hamamoto, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin. Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane. Biochemical Journal. 2024
  • Hiroyuki Takatsu, Narumi Nishimura, Yusuke Kosugi, Haruo Ogawa, Kazuhisa Nakayama, Estelle Colin, Konrad Platzer, Rami Abou Jamra, Silke Redler, Clément Prouteau, et al. De Novo Missense Variations of ATP8B2 Impair Its Phosphatidylcholine Flippase Activity. Molecular and Cellular Biology. 2024. 1-16
  • Taiju Fujii, Luxiaoxue Liang, Kazuhisa Nakayama, Yohei Katoh. Defects in diffusion barrier function of ciliary transition zone caused by ciliopathy variations of TMEM218. Human Molecular Genetics. 2024
  • Saishu Yoshida, Akira Kawamura, Katsuhiko Aoki, Pattama Wiriyasermkul, Shinya Sugimoto, Junnosuke Tomiyoshi, Ayasa Tajima, Yamato Ishida, Yohei Katoh, Takehiro Tsukada, et al. Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 28. e2320070121
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MISC (50)：
  • 千葉秀平, 加藤洋平, 中山和久. Imaging of cilia and centrosome by Expansion Microscopy. Bio Clinica. 2022. 37. 11
  • 加藤洋平, 千葉秀平, 中山和久. Observation of primary cilia and centrioles by expansion microscopy. 実験医学. 2022. 40. 16
  • 加藤洋平, 千葉秀平, 中山和久. Superresolution imaging of primary cilia by expansion microscopy using an amplibody for fluorescence signal amplification. 生化学. 2022. 94. 4
  • 中山和久, 加藤洋平, 千葉秀平. 繊毛形成と繊毛内タンパク質輸送の分子基盤. 日本生化学会大会(Web). 2021. 94th
  • 千葉秀平, 加藤洋平, 中山和久. Super-resolution imaging of structure and assembly mechanism of the ciliary transition zone in mammalian cells. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
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Books (11)：
  • レーニンジャーの新生化学:生化学と分子生物学の基本原理(第7版下)
    廣川書店 2019
  • レーニンジャーの新生化学:生化学と分子生物学の基本原理(第7版上)
    廣川書店 2019
  • くすりをつくる研究者の仕事:薬のタネ探しから私たちに届くまで
    化学同人 2017
  • Arfファミリーによるメンブレントラフィックの調節.メンブレントラフィック:膜・小胞による細胞内輸送ネッ トワーク
    化学同人 2016
  • レーニンジャーの新生化学:生化学と分子生物学の基本原理(第6版下)
    廣川書店 2015 ISBN:4567244079
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Lectures and oral presentations  (20)：
  • 繊毛内タンパク質輸送複合体の構築様式と機能.
    (第41回蛋白質の酵素の構造と機能に関する九州シンポジウム 2016)
  • Trafficking Machineries within Cilia: Arc hitectures and Functions of the IFT-A and IFT-B complexes.
    (68回日本細胞生物学会大会シンポジウム「高次生命機能を司るメンブレ ントラフィック:分子基盤からその破綻による疾患発症の理解に向けて」 2016)
  • Regulation of cell division by membrane traffic involving Rab and Arf families of small GTPases
    (International Symposium: Epigenetic Landscape in Biological Rhythms, “RNA and Clock” 2015)
  • Architecture of multi-subunit complexes involved in membrane trafficking revealed by visible immunopreci pitation (VIP) assay.
    (The 18th iCeMS International Symposium/The 15th International Membrane Research Forum. 2015)
  • メンブレントラフィックと連動する動物細胞の細胞質分裂
    (第66回日本細胞生物学会大会シンポジウム 2014)
ｍore...
Education (3)：
  • 1983 - 1987 Kyoto University Graduate School of Medicine
  • 1981 - 1983 Kyoto University Graduate School of Pharmaceutical Sciences
  • 1977 - 1981 Kyoto University Faculty of Pharmaceutical Sciences
Professional career (1)：
  • 医学博士 (京都大学)
Work history (4)：
  • 2003/05 - 現在 Kyoto University Graduate School of Pharmaceutical Sciences Professor
  • 2002/04 - 2003/04 Kanazawa University Faculty of Pharmaceutical Sciences Professor
  • 1994/01 - 2002/03 University of Tsukuba Institute of Biological Sciences Associate Professor
  • 1987/04 - 1994/01 University of Tsukuba Institute of Biological Sciences Assistant Professor
Awards (5)：
  • 2017 - 日本生化学会 JB論文賞 Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis. (2016) J. Biochem., 159, 201-208.
  • 2013/10 - Best Teacher Award
  • 2013 - 日本細胞生物学会 CSF Award Mitosis-Coupled, Microtubule-Dependent Clustering of Endosomal Vesicles around Centrosomes. (2013) Cell Struct. Funct., 38, 31-41.
  • 2001 - 日本生化学会 JB論文賞 Identification and characterization of novel isoforms of COP I subunits. (2000) J. Biochem., 128, 793-801.
  • 1994 - 日本生化学会 日本生化学会奨励賞 生理活性ペプチドおよびタンパク質前駆体のプロセシング酵素に関する研究
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