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J-GLOBAL ID：201401049082985937 Update date: Mar. 05, 2025

Nakayama Kazuhisa

Affiliation and department：
Homepage URL (1)： http://www.pharm.kyoto-u.ac.jp//physchem/

Research field (1)： Cell biology

Research theme for competitive and other funds (25)：

2024 - 2027 繊毛内タンパク質輸送の異常に起因する繊毛病を分子から細胞分化のレベルで理解する
2019 - 2024 Relationship between architecture and function of intraciliary protein trafficking complex: molecular basis for ciliopathies
2020 - 2022 Architecture of the transition zone separating the cytoplasm and cilioplasmand, and selective protein translocation across it
2015 - 2018 Regulation of vesicular trafficking by tethering complex and SNARE proteins
2015 - 2017 タンパク質間相互作用解析とイメージングに基づく繊毛形成と繊毛内輸送機構の解明

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Papers (236)：

Koshi Tasaki, Yuuki Satoda, Shuhei Chiba, Hye-Won Shin, Yohei Katoh, Kazuhisa Nakayama. Mutually independent and cilia-independent assembly of IFT-A and IFT-B complexes at mother centriole. Molecular Biology of the Cell. 2025
Yuto Takahashi, Yamato Ishida, Saishu Yoshida, Hye-Won Shin, Yohei Katoh, Kazuhisa Nakayama. Counterregulatory roles of GLI2 and GLI3 in osteogenic differentiation via Gli1 expression. Journal of Cell Science. 2025
Shingo Yamazaki, Taiju Fujii, Shuhei Chiba, Hye-Won Shin, Kazuhisa Nakayama, Yohei Katoh. TXNDC15, an ER-localized thioredoxin-like transmembrane protein, contributes to ciliary transition zone integrity. Journal of Cell Science. 2024
Tsukasa Yagi, Riki Nakabuchi, Yumeka Muranaka, Gaku Tanaka, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin. Lipid flippases ATP9A and ATP9B form a complex and contribute to the secretory pathway from the Golgi apparatus. 2024
Yumeka Muranaka, Ryo Shigetomi, Yugo Iwasaki, Asuka Hamamoto, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin. Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane. Biochemical Journal. 2024

MISC (50)：

千葉秀平, 加藤洋平, 中山和久. Imaging of cilia and centrosome by Expansion Microscopy. Bio Clinica. 2022. 37. 11
加藤洋平, 千葉秀平, 中山和久. Observation of primary cilia and centrioles by expansion microscopy. 実験医学. 2022. 40. 16
加藤洋平, 千葉秀平, 中山和久. Superresolution imaging of primary cilia by expansion microscopy using an amplibody for fluorescence signal amplification. 生化学. 2022. 94. 4
中山和久, 加藤洋平, 千葉秀平. 繊毛形成と繊毛内タンパク質輸送の分子基盤. 日本生化学会大会(Web). 2021. 94th
千葉秀平, 加藤洋平, 中山和久. Super-resolution imaging of structure and assembly mechanism of the ciliary transition zone in mammalian cells. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th

Books (11)：

Lectures and oral presentations (20)：

繊毛内タンパク質輸送複合体の構築様式と機能.
(第41回蛋白質の酵素の構造と機能に関する九州シンポジウム 2016)
Trafficking Machineries within Cilia: Arc hitectures and Functions of the IFT-A and IFT-B complexes.
(68回日本細胞生物学会大会シンポジウム「高次生命機能を司るメンブレントラフィック:分子基盤からその破綻による疾患発症の理解に向けて」 2016)
Regulation of cell division by membrane traffic involving Rab and Arf families of small GTPases
(International Symposium: Epigenetic Landscape in Biological Rhythms, “RNA and Clock” 2015)
Architecture of multi-subunit complexes involved in membrane trafficking revealed by visible immunopreci pitation (VIP) assay.
(The 18th iCeMS International Symposium/The 15th International Membrane Research Forum. 2015)
メンブレントラフィックと連動する動物細胞の細胞質分裂
(第66回日本細胞生物学会大会シンポジウム 2014)

Education (3)：

Professional career (1)：

Work history (4)：

2003/05 - 現在 Kyoto University Graduate School of Pharmaceutical Sciences Professor
2002/04 - 2003/04 Kanazawa University Faculty of Pharmaceutical Sciences Professor
1994/01 - 2002/03 University of Tsukuba Institute of Biological Sciences Associate Professor
1987/04 - 1994/01 University of Tsukuba Institute of Biological Sciences Assistant Professor

Awards (5)：

2017 - 日本生化学会 JB論文賞 Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis. (2016) J. Biochem., 159, 201-208.
2013/10 - Best Teacher Award
2013 - 日本細胞生物学会 CSF Award Mitosis-Coupled, Microtubule-Dependent Clustering of Endosomal Vesicles around Centrosomes. (2013) Cell Struct. Funct., 38, 31-41.
2001 - 日本生化学会 JB論文賞 Identification and characterization of novel isoforms of COP I subunits. (2000) J. Biochem., 128, 793-801.
1994 - 日本生化学会日本生化学会奨励賞生理活性ペプチドおよびタンパク質前駆体のプロセシング酵素に関する研究

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