Yanaka Saeko

Affiliation and department：
Job title： Associate Professor
Other affiliations (2)：

National Institutes of Natural Sciences Institute for Molecular Science and Exploratory Research Center on Life and Living Systems Associate Professor
Kyushu University Graduate School of Pharmaceutical Sciences Associate Professor

Research field (2)： Pharmaceuticals - analytical and physicochemistry , Biophysics

Research keywords (2)： Nuclear Magnetic Resonance , Biomolecular engineering

Research theme for competitive and other funds (11)：

2023 - 2026 実験科学と情報科学の融合によるバイオ医薬品設計の技術開発
2022 - 2026 Deciphering and modifying the molecular meridians of antibodies to enhance the functionality of therapeutic antibodies
2021 - 2026 分子中に秘められた新規相互作用部位の探査と改変を通じた次世代抗体創成の基盤構築
2019 - 2023 Elucidation of the functional mechanisms associated with structural dynamics of antibodies by integration of cutting-edge measurement approaches
2020 - 2022 糖鎖とタンパク質が織りなす抗体のアロステリックネットワークの探査

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Papers (67)：

Jumpei Tagawa, Saeko Yanaka, Yuri Kato, Akitsu Masuda, Jae Man Lee, Akinobu Senoo, Kosuke Oyama, Motohiro Nishida, Takahiro Kusakabe, Jose M.M. Caaveiro. Characterization of high affinity IgM and IgG monoclonal antibodies against norovirus variants GII.4 and GII.17. 2024
Yuuki Koseki, Yuki Yamaguchi, Michihiko Aoyama, Minoru Tada, Akinobu Senoo, Akiko Ishii-Watabe, Takayuki Uchihashi, Susumu Uchiyama, Koichi Kato, Saeko Yanaka, et al. Key role of Pro230 in the hinge region on the IgG architecture and function. 2024
Saeko Yanaka, Atsuji Kodama, Shigetaka Nishiguchi, Rina Hiramine, Jiana Shen, Pornthip Boonsri, Duckyong Sung, Yukiko Isono, Hirokazu Yagi, Yohei Miyanoiri, et al. Identification of potential C1-binding sites in the immunoglobulin CL domains. International Immunology. 2024
Saeko Yanaka, Hiroki Watanabe, Rina Yogo, Mesayamas Kongsema, Sachiko Kondo, Hirokazu Yagi, Takayuki Uchihashi, Koichi Kato. Quantitative Analysis of Therapeutic Antibody Interactions with Fcγ Receptors Using High-Speed Atomic Force Microscopy. Biological & pharmaceutical bulletin. 2024. 47. 1. 334-338
Methanee Hiranyakorn, Maho Yagi-Utsumi, Saeko Yanaka, Naoya Ohtsuka, Norie Momiyama, Tadashi Satoh, Koichi Kato. Mutational and Environmental Effects on the Dynamic Conformational Distributions of Lys48-Linked Ubiquitin Chains. International Journal of Molecular Sciences. 2023. 24. 7. 6075

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MISC (10)：

谷中冴子, 谷中冴子, 谷中冴子, 加藤晃一, 加藤晃一. 抗体医薬の作動メカニズムの分子基盤. 生物工学会誌. 2023. 101. 7
中野里音, 山田梨乃, 西栄美子, 斎藤泰輝, 犬塚健剛, 足達俊吾, 戸島拓郎, 古川潤一, 本田怜奈, 谷中冴子, et al. Regulatory mechanism of protein glycosylation by passport sequence. 日本薬学会年会要旨集(Web). 2023. 143rd
加藤晃一, 加藤晃一, 谷中冴子, 谷中冴子. Antibody effector functions and functional improvement of antibodies via their constant regions. 実験医学. 2022. 40. 20
谷中冴子, 加藤晃一. 複雑な糖鎖のコンフォメーション空間の探査と改変-計算と実験の統合によるアプローチ. 化学. 2020. 75. 8
矢木宏和, 鈴木達哉, 鈴木達哉, 鈴木達哉, 谷中冴子, 谷中冴子, 谷中冴子, 山口拓実, 山口拓実, 加藤晃一, et al. 核磁気共鳴分光法と分子動力学計算を通じて観る糖鎖の動的構造とレクチンの糖鎖認識の理解. 医学のあゆみ. 2019. 269. 9

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Books (1)：

Experimental approaches of NMR spectroscopy : methodology and application to life science and materials science
Springer 2018 ISBN:9789811059650

Lectures and oral presentations (54)：

Analysis of antibody interaction and function in serum
(日本薬学会年会要旨集(Web) 2021)
Development of method for studying dynamical structures and interactions of antibodies and its applications to antibody engineering
(日本薬学会年会要旨集(Web) 2021)
High-precision structural analysis of antibody molecules by SEC-iCM-SANS
(量子ビームサイエンスフェスタ(Web) 2021)
安定同位体標識を利用したNMRによる抗体の「品質」の解析
(日本分子生物学会年会プログラム・要旨集(Web) 2019)
抗体のNMR解析のための安定同位体標識法の開発と応用
(Abstracts. Annual Meeting of the NMR Society of Japan 2019)

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Education (4)：

2010 - 2013 The University of Tokyo Graduate School of Frontier Sciences Department of Medical Genome Sciences
2008 - 2010 The University of Tokyo Graduate School of Frontier Sciences Department of Medical Genome Sciences
2006 - 2008 The University of Tokyo The Faculty of Engineering Department of Chemistry and Biotechnology
2003 - 2006 The University of Tokyo College of Arts and Sciences

Professional career (1)：

Work history (7)：

2024/04 - 現在 Tokyo Institute of Technology Institute of Innovative Research Associate Professor
2022/09 - 2024/03 九州大学大学院薬学研究院講師
2017/11 - 2022/08 National Institutes of Natural Sciences
2015/07 - 2017/10 National Institutes of Natural Sciences
2015/04 - 2015/06 京都大学工学研究科分子工学専攻日本学術振興会特別研究員(PD)

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Committee career (4)：

Awards (7)：

2021/03 - 日本薬学会物理系薬学部会物理系薬学部会奨励賞抗体の3次元構造と相互作用のダイナミクスを解明する方法の開発と抗体の高機能化への展開
2015/02 - Inoue Foundation for Science the 32nd Inoue Research Award for Young Scientists
2013/11 - 日本核磁気共鳴学会若手ポスター賞I
2013/06 - 日本蛋白質科学会若手奨励賞
2011/09 - メルク株式会社第四回"Merck Award for Young Biochemistry Researcher"優秀賞

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Association Membership(s) (4)：

THE PHARMACEUTICAL SOCIETY OF JAPAN , THE BIOPHYSICAL SOCIETY OF JAPAN , PROTEIN SCIENCE SOCIETY OF JAPAN , 日本核磁気共鳴学会

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