Mino Takashi

ミノタカシ | Mino Takashi

Affiliation and department：

Research field (4)： Cell biology , Molecular biology , Medical biochemistry , Immunology

Research keywords (5)： Cytokine , Translation , RNA degradation , Post-transcriptional regulation , Immunology

Research theme for competitive and other funds (4)：

2018 - 2023 Analysis of immune regulatory mechanisms mediated by mRNA metabolism
2019 - 2022 Study of mRNA translation in immune system
2016 - 2019 Study of UPF1-mediated mRNA regulation in immune system
2013 - 2015 Analysis of posttranscriptional mechanisms of Regnase-1-mediated mRNA decay in innate immune system

Papers (38)：

Noriki Iwai, Kotaro Akaki, Fabian Hia, Wei Li, Masanori Yoshinaga, Takashi Mino, Osamu Takeuchi. UPF1 plays critical roles in early B cell development. Nature Communications. 2024. 15. 1. 5765
Takuya Uehata, Shinnosuke Yamada, Daisuke Ori, Alexis Vandenbon, Amir Giladi, Adam Jelinski, Yasuhiro Murakawa, Hitomi Watanabe, Kazuhiro Takeuchi, Kazunori Toratani, et al. Regulation of lymphoid-myeloid lineage bias through regnase-1/3-mediated control of Nfkbiz. Blood. 2024. 143. 3. 243-257
Ai Yaku, Tadakatsu Inagaki, Ryotaro Asano, Makoto Okazawa, Hiroyoshi Mori, Ayuko Sato, Fabian Hia, Takeshi Masaki, Yusuke Manabe, Tomohiko Ishibashi, et al. Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages. Circulation. 2022. 146. 13. 1006-1022
Ka Man Tse, Alexis Vandenbon, Xiaotong Cui, Takashi Mino, Takuya Uehata, Keiko Yasuda, Ayuko Sato, Tohru Tsujimura, Fabian Hia, Masanori Yoshinaga, et al. Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates inflammatory diseases. Science translational medicine. 2022. 14. 644. eabo2137
Yee Kien Chong, Sarang Tartey, Yuki Yoshikawa, Koshi Imami, Songling Li, Masanori Yoshinaga, Ai Hirabayashi, Guohao Liu, Alexis Vandenbon, Fabian Hia, et al. Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism. Science signaling. 2022. 15. 729. eabm5011

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MISC (7)：

吉永正憲, 三野享史, BASSIK Michael C, 竹内理. 鉄代謝を制御する転写後調節機構の解明. 日本RNA学会年会要旨集. 2018. 20th
吉永正憲, 三野享史, 竹内理. Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する. 日本分子生物学会年会プログラム・要旨集(Web). 2018. 41st
Yoshinari Nakatsuka, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Toyohiro Hirai Hirai, Osamu Takeuchi. Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity. CYTOKINE. 2017. 100. 39-39
吉永正憲, 三野享史, 竹内理. Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する. 日本生化学会大会(Web). 2017. 90th
吉永正憲, 三野享史, 竹内理. Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する. 日本RNA学会年会要旨集. 2017. 19th

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Patents (1)：

Education (3)：

2006 - 2009 Kyoto University Graduate School of Engineering Department of Synthetic Chemistry and Biological Chemistry
2004 - 2006 Kyoto University Graduate School of Engineering Department of Synthetic Chemistry and Biological Chemistry
2002 - 2004 Kyoto University Faculty of Engineering School of Industrial Chemistry

Professional career (1)：

Work history (6)：

2019/04 - 現在 Kyoto University Graduate School of Medicine Assistant Professor
2016/10 - 2019/03 Kyoto University Institute for Frontier Life and Medical Sciences Assistant Professor
2012/06 - 2016/09 Kyoto University Institute for Virus Research Assistant Professor
2010/04 - 2012/06 Osaka University WPI Immunology Frontier Research Center Specially Appointed Researcher
2009/04 - 2010/03 The University of California, San Diego School of Medicine Postdoctoral Fellow

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Awards (3)：

Association Membership(s) (2)：

日本RNA学会 , 日本免疫学会

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