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J-GLOBAL ID：201401058009175950 Update date: Mar. 29, 2025

Kazuhiro Maeshima

マエシマカズヒロ | Kazuhiro Maeshima

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Affiliation and department：
Job title：教授
Other affiliations (1)：

RIKEN Visiting Scientist

Homepage URL (2)： http://maeshima-lab.sakura.ne.jp , http://maeshima-lab.sakuraweb.com

Research field (5)： Biophysics , Cell biology , Molecular biology , Nanobioscience , Nanomaterials

Research keywords (26)：染色体 , ゲノム , 核酸 , 生体分子 , ヒトゲノム , 構造 , 電子顕微鏡 , クロマチン , 核膜 , 細胞核 , イメージング , コンデンシン , 生物物理 , トポイソメラーゼII , ライブイメージング , X線 , 分裂期染色体 , 遺伝学 , 核膜孔 , 生体高分子 , 生体生命情報学 , 高次構造 , ナノ構造解析 , 生細胞イメージング , 位相回復 , X線回折顕微法

Research theme for competitive and other funds (22)：

2024 - 2029 超解像イメージングで明らかにするクロマチンドメインとその細胞機能制御
2023 - 2026 A novel fluorescence anisotropy imaging for imaging nano-scale LLPS in living cells
2020 - 2025 Genome modality: understanding physical properties of the genome
2020 - 2025 Modality of nucleosome dynamics
2021 - 2024 新規ヌクレオソームイメージングを用いた生細胞におけるクロマチンの高次構造の解明

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Papers (108)：

Shin Fujishiro, Masaki Sasai, Kazuhiro Maeshima. Chromatin domains in the cell: Phase separation and condensation. Current Opinion in Structural Biology. 2025. 91. 103006
Katsuhiko Minami, Kako Nakazato, Satoru Ide, Kazunari Kaizu, Koichi Higashi, Sachiko Tamura, Atsushi Toyoda, Koichi Takahashi, Ken Kurokawa, Kazuhiro Maeshima. Replication-dependent histone labeling dissects the physical properties of euchromatin/heterochromatin in living human cells. Science Advances. 2025. 11. 13
Masa A. Shimazoe, Charles Phillips, Jan Huertas, Satoru Ide, Sachiko Tamura, Stephen Farr, S. S. Ashwin, Masaki Sasai, Rosana Collepardo-Guevara, Kazuhiro Maeshima. Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells. 2025
Katsuhiko Minami, Satoru Ide, Kako Nakazato, Kazunari Kaizu, Koichi Higashi, Sachiko Tamura, Atsushi Toyoda, Koichi Takahashi, Ken Kurokawa, Kazuhiro Maeshima. Replication-dependent histone (Repli-Histo) labeling dissects the physical properties of euchromatin/heterochromatin in living human cells. bioRxiv. 2024
Shiori Iida, Satoru Ide, Sachiko Tamura, Masaki Sasai, Tomomi Tani, Tatsuhiko Goto, Michael Shribak, Kazuhiro Maeshima. Orientation-independent-DIC imaging reveals that a transient rise in depletion attraction contributes to mitotic chromosome condensation. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 36. e2403153121

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MISC (46)：

井手聖, 前島一博. 相分離モデルで理解する転写制御〜核小体と転写コンデンセート〜. 生体の科学. 2023. 74. 234-239
飯田史織, 前島一博. 生きた細胞のなかのヌクレオソームの動きをみる. 現代化学 3月号. 2023. 624. 51-53
飯田史織, 前島一博. 【DNAの物性から理解するゲノムモダリティ】核内クロマチンの物理的な性質. 細胞. 2022. 54. 11. 624-627
島添將誠, 井手聖, 前島一博. 【セントラルドグマの新常識転写・翻訳の驚きの新機構と再定義されるDNA・RNA・タンパク質の世界】(第1章)DNAの新常識物性から迫るクロマチンの実像相分離するクロマチンは液体か?固体か?. 実験医学. 2022. 40. 12. 1850-1859
井手聖, 前島一博. 【今、解き明かされつつある液-液相分離による生体機能制御】核内構造体と液-液相分離核小体と転写コンデンセートを中心に. 生化学. 2022. 94. 4. 485-493

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Books (7)：

How small numbers of long genomic DNA are stored in cells
Springer, Singapore 2018
遺伝子発現制御機構
東京化学同人 2017
少数性生物学の世界
日本評論社 2017
Combination approach of live-cell imaging and computational modeling toward further comprehensive understanding genome, chromatin and epigenetics
Academic 2017
Dynamic chromatin folding in the cell
Academic Press 2017 ISBN:0128034807

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Lectures and oral presentations (66)：

Nucleosome behaviors in live human cells revealed by single-nucleosome imaging.
(Friday Virtual Seminar 2025)
Replication-dependent histone (Repli-Histo) labeling specifically visualizes the physical properties of euchromatin/heterochromatin in living human cells
(1st International Conference on Cell Organization and Genome Integrity 2024)
Replication-dependent histone (Repli-Histo) labeling specifically visualizes the physical properties of euchromatin/heterochromatin in living human cells
(The 12th 3R+3C International Symposium 2024)
Nucleosome behavior during interphase cell cycle revealed by single-nucleosome imaging
(Genome Organisation Australia Webinar 2024 2024)
細胞の中のDNA - 遺伝情報検索原理の解明を目指して -
(ROISの新たな挑戦シリーズII 2024)

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Education (3)：

1995 - 1999 Osaka University
1993 - 1995 Osaka University
1989 - 1993 University of Tsukuba

Professional career (1)：

Ph.D. (Osaka University)

Work history (12)：

2024/04 - 現在 Head, Department of Chromosome Science, National Institute of Genetics
2023/04 - 現在 Genetics Course, Graduate Institute for Advanced Studies, SOKENDAI Professor
2019/04 - 現在 National Institute of Genetics Department of Chromosome Science Professor
2022/04 - 2024/03 National Institute of Genetics Assistant to the Director-General
2009/04 - 2023/03 SOKENDAI Department of Genetics, School of Life Science Professor

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Awards (1)：

2016/05 - Kihara Memorial Foundation 2015 Kihara Memorial Foundation Academic Award

Association Membership(s) (5)：

THE JAPANESE SOCIETY FOR SYNCHROTRON RADIATION RESEARCH , THE BIOPHYSICAL SOCIETY OF JAPAN , JAPAN SOCIETY FOR CELL BIOLOGY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , American Society for Cell Biology

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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