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J-GLOBAL ID：201401086539368982   Update date: Jul. 17, 2024

Shibata Tomonori

シバタ トモノリ | Shibata Tomonori
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Affiliation and department：
Liid Pharmaceuticals Inc.

About Liid Pharmaceuticals Inc.


Other affiliations (1)：
Homepage URL  (1)： https://www.sanken.osaka-u.ac.jp/labs/rbc/
Research field  (1)： Bioorganic chemistry
Research theme for competitive and other funds  (6)：
  • 2022 - 2025 Elucidation of the binding pathway of mismatch-binding molecules to abnormally elongated repeat sequences and their shortening-inducing effects
  • 2020 - 2024 脊髄小脳変性症31型を標的とする低分子の作用機序解明と毒性リピートRNA機能抑制
  • 2021 - 2023 CAGリピート結合分子の経鼻投与後における脳内動態解明及びリピート短縮効果の検証
  • 2017 - 2019 脊髄小脳失調症31型モデル個体に効果を示すRNAリピート結合分子の作用機序解明
  • 2014 - 2016 RNA/RNPナノ構造を利用した機能性分子ロボットの創製
Show all
Papers (19)：
  • Eitaro Murakami, Masayuki Nakamori, Kazuhiko Nakatani, Tomonori Shibata, Kazuki Tainaka. Intracerebral Distribution of CAG Repeat-Binding Small Molecule Visualized by Whole-Brain Imaging. Bioconjugate Chemistry. 2023
  • Tomonori Shibata, Yasumasa Matsumoto, Akiko Iihara, Kazunori Yamada, Hiroshi Ochiai, Ryo Saito, Shinichi Kusaka, Toshiyuki Kume. Fluorescent indicator displacement assay for the discovery of UGGAA repeat-targeted small molecules. Chemical Communications. 2023. 59. 34. 5071-5074
  • Tomonori Shibata, Kazuhiko Nakatani. A small molecule binding to TGGAA pentanucleotide repeats that cause spinocerebellar ataxia type 31. Bioorganic and Medicinal Chemistry Letters. 2023. 79
  • Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani. Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model. Nature Communications. 2021. 12. 1
  • Masaki Hagihara, Chikara Dohno, Kaoru Saito, Kazuhiro Sugimoto, Yuta Hishinuma, Yuri Sohma, Tomonori Shibata, Kazuhiko Nakatani. Short Tandem Repeat Contractions during in vitro DNA Synthesis by Repeat-Binding Molecules. Chemistry Letters. 2021
ｍore...
Patents (1)：
Education (1)：
  • 2010 - 2013 Osaka University
Professional career (1)：
  • 理学博士 (大阪大学)
Work history (3)：
  • 2018/04 - 現在 Osaka University The Institute of Scientific and Industrial Research
  • 2015/07 - 2018/03 Osaka University The Institute of Scientific and Industrial Research
  • 2013/04 - 2015/06 Kyoto University
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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