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J-GLOBAL ID：201401096155859151 Update date: Apr. 02, 2025

Kobori Takuro

コボリタクロウ | Kobori Takuro

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Affiliation and department：
Job title： Lecturer

Research field (4)： Fetal medicine/Pediatrics , Tumor diagnostics and therapeutics , Pharmacology , Clinical pharmacy

Research keywords (8)： Pediatric cancer , Ovarian Clear Cell Carcinoma , Glioblastoma , Adolescent and Young Adult , Scaffold Protein Ezrin/Radixin/Moesin , Immune Checkpoint Molecule , 核酸医薬品 , cancer immunotherapy

Research theme for competitive and other funds (16)：

2024 - 2026 Development of a novel immune checkpoint blockade therapy targeting the intracellular scaffold protein for ovarian clear cell carcinoma common in Japanese women
2024 - 2025 .
2024 - 2025 Development of macrophage immune checkpoint blockade therapy for the refractory glioblastoma.
2023 - 2024 .
2023 - 2024 Development of innate immune checkpoint blockade therapy for ovarian clear cell adenocarcinoma

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Papers (53)：

Takuro Kobori, Yui Ito, Yoko Urashima, Takuya Ito, Nobumasa Takagaki, Kikuko Hotta, Tokio Obata. Ezrin works as a scaffold protein for a macrophage checkpoint molecule CD47, leading to a poor prognosis for patients with uterine cervical squamous cell carcinoma. Taiwanese journal of obstetrics & gynecology. 2025. 64. 2. 239-247
Takuro Kobori, Mikiko Sugimoto, Takuya Ito, Kikuko Hotta. Involvement of Intracellular Scaffold Proteins in the Expression of Immune Checkpoint Molecule PD-L1 and Prognosis in Patients with Glioblastoma. Journal of AYA Oncology Alliance. 2024. 4. 2. 35-45
森田剛生, 浦嶋庸子, 梶原千聖, 末光優香, 浦嶋和也, 鈴木薫, 倉地果純, 西原雅美, 小堀宅郎, 梅本知輝, et al. 経腸栄養剤の1週間連続投与がラットの血中フェニトイン濃度に与える影響. TDM研究. 2024. 41. 2. 182-182
森田剛生, 浦嶋庸子, 梶原千聖, 末光優香, 浦嶋和也, 鈴木薫, 倉地果純, 西原雅美, 小堀宅郎, 梅本知輝, et al. 経腸栄養剤の1週間連続投与がラットの血中フェニトイン濃度に与える影響. TDM研究. 2024. 41. 2. 182-182
Takuro Kobori, Yui Ito, Chihiro Tanaka, Yoko Urashima, Tomoyo Yamamura, Nobumasa Takagaki, Tokio Obata. Changes in the macrophage polarization status and the kinetics of immune-related factors in the ascites of patients with pancreatic cancer before and after cell-free and concentrated ascites reinfusion therapy. Japanese Journal of Community Medicine and Pharmaceutical Sciences. 2024. 11. 1. 35-45

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MISC (55)：

小堀宅郎, 伊藤優衣, 浦嶋庸子, 伊藤卓也, 堀田紀久子, 小畑友紀雄. Role of ERM proteins in the plasma membrane expression of PD-L1 in the ovarian clear cell adenocarcinoma common in Japanese women. 日本薬学会年会要旨集(Web). 2024. 144th
伊藤優衣, 小堀宅郎, 浦嶋庸子, 伊藤卓也, 堀田紀久子, 小畑友紀雄. Moesin affects the expression and functionality of an innate immune checkpoint molecule CD47 in human ovarian clear cell adenocarcinoma. 日本薬学会年会要旨集(Web). 2024. 144th
澤田優果, 伊藤優衣, 小堀宅郎, 浦嶋庸子, 伊藤卓也, 高垣伸匡, 小畑友紀雄. Ezrin modulates the cellular membrane localization of the macrophage checkpoint molecule CD47 in human uterine cervical squamous cell carcinoma. 日本薬学会年会要旨集(Web). 2024. 144th
小堀宅郎, 伊藤優衣, 田中千都, 浦嶋庸子, 山村智代, 高垣伸匡, 小畑友紀雄. 腹水濾過濃縮再静注法の施行前後における膵臓癌患者の腹水中免疫微小環境の解析. 日本在宅薬学会学術大会プログラム・講演抄録集. 2023. 16回. 166-166
岩永菜那, 浦嶋庸子, 浦嶋和也, 鈴木薫, 小堀宅郎, 小畑友紀雄. 経腸栄養剤および経腸栄養食品が消化管からのタクロリムス吸収におよぼす影響. TDM研究. 2023. 40. 2. 182-182

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Patents (2)：

コンドロイチン硫酸生合成を阻害するアンチセンス核酸
REGULATOR OF EXPRESSION AND/OR FUNCTION OF SCN1A GENE

Education (3)：

2011 - 2014 Kobe Gakuin University Graduate School of Food and Pharmaceutical Sciences
2009 - 2011 Tohoku Pharmaceutical University Graduate School of Pharmaceutical Sciences
2005 - 2009 Tohoku Pharmaceutical University Faculty of Pharmacy

Professional career (1)：

Ph.D. (Kobe Gakuin University)

Work history (7)：

2023/07 - 現在 Graduate School of Pharmaceutical Sciences, Osaka Ohtani University
2023/07 - 現在 Faculty of Pharmacy, Osaka Ohtani University Laboratory of Pathophysiology and Pharmacotherapeutics Lecturer
2020/08 - 2023/06 Osaka Ohtani University Faculty of Phamacy Assistant Professor
2019/08 - 2020/07 大阪大学大学院薬学研究科
2019/04 - 2020/07 ルクサナバイオテク株式会社研究開発部

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Awards (10)：

2023/07 - The Japanese Association of Home Care Pharmacies Best Presentation Award in The 16th Congress of The Japanese Association of Home Care Pharmacies Analysis for Ascitic Immune Microenvironment in Patients with Pancreatic Cancer Receiving Before and After CART
2016 - The Japanese Society for the Study of Xenobiotics DMPK Editors’ Award for the Most Excellent Article in 2014 2nd place
2014/03 - 日本薬学会日本薬学会第 134 年会優秀発表賞
2013/09 - 日本緩和医療薬学会第 7 回日本緩和医療薬学会年会優秀発表賞
2013/08 - 日本薬学会薬理系薬学部会生体機能と創薬シンポジウム 2013 優秀発表賞

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Association Membership(s) (8)：

Japanese Society of Pharmaceutical Oncology , The Japanese Association of Home Care Pharmacies , AYA Oncology Alliance , THE JAPANESE PHARMACOLOGICAL SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本医療薬学会 , The Pharmacy Society of Japan , THE JAPANESE SOCIETY OF TOXICOLOGY

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